Neurodevelopment and disease mechanisms

Substantial progress has been made in the identification of risk genes for neurodevelopmental psychiatric disorders such as autism and ADHD. However, the physiological function of most risk genes and their role in disease mechanisms still remains elusive for most psychiatric disorders.

Relevance of risk genes

In our research group, we address basic questions regarding the function of risk genes during brain development. We investigate their expressions in relation to specific types of neurons, their role in biological pathways with relevance for brain development and finally how they impact on brain structure, function and behavior.

Approach

For our research we use zebrafish, a versatile vertebrate model organism. The zebrafish is an ideal model system to address such questions. Numerous genetic tools to manipulate gene activity and to visualize neurons and brain structures are available. The transparency and comparatively small size of the developing zebrafish brain allows imaging of an intact brain by light microscopy.

Effects on behavior

Moreover, procedures to monitor and quantify behaviors such as locomotor activity, day-night activity, social interaction and approach and avoidance are established. Thereby we explore the role of risk genes for neurodevelopmental psychiatric disorders at molecular, structural and behavioral levels. We are using a combination of molecular biology, pharmacology, imaging and behavior testing.