The genes on the track
We are also providing different model systems for modelling genetic cardiac diseases. Here, we are able to help with the generation and differentiation of cardiac cells from human induced pluripotent stem cells (iPSCs) as well as to help with gene editing via CRISPR/Cas9 technology of iPSCs. In addition, we also use the developing and adult zebrafish as a model system to investigate genetic cardiovascular disease. We do have a zebrafish facility for housing zebrafish and provide the technology to phenotypically characterize the heart in health and disease. There are different background lines and genetic models (knock-out, knock-in of specific cardiac genes) available.