Third-Party Funded Projects on Neurodegenerative Diseases

FTLD-Study

Study funded by the German Federal Ministry of Education and Research and conducted by the national FTLD consortium
Principal investigator: Martin Lauer
Project duration 2011-2017

Clinical picture

Frontotemporal dementia is a kind of dementia of high clinical relevance, as it is found primarily in younger patients (unter 65, average age of about 55). The term "frontotemporal lobar degeneration" (FTLD) describes a range of neurodegenerative diseases affecting mainly the frontal and temporal lobe of the brain. Initially, those diseases were called "M. Pick" because of the rare disease of the same name.

Clinically, those diseases can be subdivided into two predominant groups of symptoms:

1) patients with behavioural problems and abnormalities and

2) patients with speech disorders.

Extrapyramidal symptoms are predominant in particular in corticobasal degeneration and progressive supranuclear palsy.

FTLD diseases include:

  • Frontotemporal dementia
  • Primary nonfluent aphasia
  • Semantic dementia
  • Corticobasal syndrome
  • Progressive supranuclear palsy
  • Amyotrophic lateral sclerosis with frontotemporal dementia (ALS+FTD).

There are only a few studies regarding the frequency of occurrence of FTLD. However, it must be stated that the group of diseases subsumed under FTLD are the second most frequent type of dementia in patients under 65. Regarding the etiology, significant progress was made by the neuropathological identification of tau aggregates, deposition of TDP43 and deposition of FUS, as well as by identifying several risk genes.

Unfortunately, as of yet, there are no therapy guidelines even for symptomatic treatment of patients with frontotemporal lobar degeneration.

Goals and objectives of the study

The main goal of the FTLD consortium is to develop and evaluate parameters for monitoring patients with early stage and later stage frontotemporal lobar degeneration, in order to eventually devise effective and objective variables for therapeutic strategies.

We also aim at establishing facilities and support for patients as well as their carers.

 

Please find more information on the website of the working group.

Head of Hospital

Portraitfoto Oberarzt PD Dr. med. Martin Lauer

PD Dr. med.
Martin Lauer

Managing consultant

+49 931 201-76560

Contact

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