Welcome to the Hudecek Lab – The home of CAR T

Jaeckel E, Friedman SL, Hudecek M, Protzer U. 
Chimeric Antigen Receptor (CAR) T-cell Therapy: Engineering Immune Cells To Treat Liver Diseases. 
J Hepatol. 2025 Jun 20:S0168-8278(25)02274-3
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De Angelis B, D'Amore ML, Lecot P, Neininger K, Lorrain M, Gambotti L, Dreuillet C, Courcault E, Chatterjee S, Delgado J, Galy A, Franz P, Rodriguez-Madoz JR, Cabrerizo Y, Richter A, Girvalaki C, Noviello M, Tassi E, Sanges C, Luu M, Hudecek M, Kremer A, Locatelli F, Negre H, Quintarelli C. 
European survey on CAR T-Cell analytical methods from apheresis to post-infusion immunomonitoring. 
Front Immunol. 2025 Apr 24;16:1567582
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Hinckley-Boned A, Barbero-Jiménez C, Tristán-Manzano M, Maldonado-Perez N, Hudecek M, Justicia-Lirio P, Martin F. 
Tailoring CAR surface density and dynamics to improve CAR-T cell therapy.
J Immunother Cancer. 2025 Apr 29;13(4):e010702
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Wegner VD, Feile A, Alb M, Hudecek M, Hewitt P, Mosig AS. 
Short-Chain Fatty Acids Modulate Anti-ROR1 CAR T-Cell Function and Exhaustion in an Intestinal Adenocarcinoma-on-Chip Model.
Adv Healthc Mater. 2025 May;14(13):e2405003
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Peter J, Toppeta F, Trubert A, Danhof S, Hudecek M, Däullary T. 
Multi-Targeting CAR-T Cell Strategies to Overcome Immune Evasion in Lymphoid and Myeloid Malignancies. 
Oncol Res Treat. 2025;48(5):265-279
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Dragon AC, Bonifacius A, Lienenklaus S, Verboom M, Gerhards JP, Ius F, Hinze C, Hudecek M, Figueiredo C, Blasczyk R, Eiz-Vesper B. Depletion of alloreactive B cells by drug-resistant chimeric alloantigen receptor T cells to prevent transplant rejection. 
Mol Ther. 2025 Mar 5;33(3):1031-1047
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Fleischer A, Kurth S, Duell J, Topp M, Strunz PP, Mersi J, Rasche L, Sanges C, Hudecek M, Einsele H, Maatouk I. 
Neuropsychiatric manifestations following chimeric antigen receptor T cell therapy for cancer: a systematic review of clinical outcomes and management strategies. 
J Immunother Cancer. 2024 Dec 22;12(12):e009174
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Jacobs JJL, Beekers I, Verkouter I, Richards LB, Vegelien A, Bloemsma LD, Bongaerts VAMC, Cloos J, Erkens F, Gradowska P, Hort S, Hudecek M, Juan M, Maitland-van der Zee AH, Navarro-Velázquez S, Ngai LL, Rafiq QA, Sanges C, Tettero J, van Os HJA, Vos RC, de Wit Y, van Dijk S. 
A data management system for precision medicine.
PLOS Digit Health. 2025 Jan 9;4(1):e0000464
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Gehrke L, Gonçalves VDR, Andrae D, Rasko T, Ho P, Einsele H, Hudecek M, Friedel SR. 
Current Non-Viral-Based Strategies to Manufacture CAR-T Cells. 
Int J Mol Sci. 2024 Dec 21;25(24):13685
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Alb M, Reiche K, Rade M, Sewald K, Loskill P, Cipriano M, Maulana TI, van der Meer AD, Weener HJ, Clerbaux LA, Fogal B, Patel N, Adkins K, Lund E, Perkins E, Cooper C, van den Brulle J, Morgan H, Rubic-Schneider T, Ling H, DiPetrillo K, Moggs J, Köhl U, Hudecek M. 
Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept.
J Immunotoxicol. 2024 Oct;21(sup1):S13-S28
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