Clinical Trials in Neurology
Our mission is to make innovative diagnostic and therapeutic approaches available to patients at an early stage and to translate new scientific findings into clinical practice.
As an academic trial site, we have extensive experience in conducting Phase II–IV clinical trials as well as non-interventional studies and registry projects. A particular focus lies on multicenter clinical trials in close collaboration with academic partners, sponsors, and CROs.
Areas of Expertise
Clinical research activities are closely integrated into the outpatient clinics and research focus areas of Neurology. The main areas of research include:
- Movement Disorders & Neuromodulation
Parkinson’s disease, tremor disorders, dystonia, Huntington’s disease, deep brain stimulation, botulinum toxin therapy - Neuroimmunology
Multiple sclerosis, myasthenia gravis, and other chronic inflammatory CNS disorders - Stroke & Neurovascular Diseases
Acute treatment, secondary prevention, diagnostic work-up - Neuromuscular Disorders
ALS, SMA, polyneuropathies, CIDP, myopathies, and rare neuromuscular diseases
The close integration with inpatient and outpatient care ensures well-established recruitment pathways and comprehensive clinical management of study participants.
Currently Recruiting Clinical Studies (as of 15 July 2026)
Enroll-HD
A Prospective Registry Study in a Global Huntington's Disease Cohort.
VERCISE DBS PD
Registry of Deep Brain Stimulation with the VERCISE™ System (Vercise DBS Registry).
VERCISE Dystonia
Registry of Deep Brain Stimulation with the VERCISE™ System for Treatment of Dystonia (Vercise DBS Dystonia Registry).
DysTract
German Network for Translational Research and Treatment of Dystonia. A multicentre registry study.
The Essential Tremor Registry (A4080)
Boston Scientific Registry of Deep Brain Stimulation for the Treatment of Essential Tremor.
ReTune
Central Database of the INF Project within Collaborative Research Centre CRC/TRR295 for the Collection of Core Clinical Data.
RAPID
Radiofrequency (RF) Ablation Prospective Outcomes Study for the Central Nervous System.
ASK-PD5-CS201 (REGENERATE-PD)
A Phase 2, Randomized, Double-blind, Sham Surgery-controlled Study of Efficacy and Safety of Intraputaminal AAV2-GDNF in the Treatment of Adults with Moderate Stage Parkinson's Disease. EU-CT: 2023-506519-16.
BN44715 (PARAISO)
A Phase III, Randomized, Double-blind, Placebo-controlled, Multicenter Study to Evaluate the Efficacy and Safety of Intravenous Prasinezumab in Participants with Early-stage Parkinson's Disease. EU-CT: 2025-522683-32-00.
STIMPulseControl
A randomized controlled trial of bilateral subthalamic stimulation in patients with Parkinson's disease and impulse control disorders.
CNIO752A12301 (PRESERVE)
A Phase III, randomized, placebo-controlled, parallel group, double-blind study to evaluate the efficacy and safety of NIO752 in participants with Progressive Supranuclear Palsy followed by an Open Label Extension. EU-CT: 2025-523481-24.
CAEHR 2.0
CArdiovascular Diseases – Enhancing Healthcare through cross-Sectoral Routine data integration.
PASSION
Thrombolysis with Tenecteplase for Acute Ischemic Stroke in Patients taking Direct Oral Anticoagulants – a multicentre randomised placebo-controlled clinical trial. EU-CT: 2025-521762-99.
LOCAL
Local Tenecteplase ApplicatiOn subsequent to endovascular Recanalization in Anterior CircuLation Stroke. EU-CT: 2024-516544-26-00.
Stroke-CORE
Cohort of the Specialist Network Stroke (SN Stroke).
LIPCAL-ALS II
Efficacy, safety and tolerability of ultra-high-caloric, fatty diet in amyotrophic lateral sclerosis.
ARGX-113-NIS-2209
Non-interventional, prospective study to understand real-world use of efgartigimod in the treatment of generalized myasthenia gravis in Germany.
ARGX-113-PASS-2208 (NaVYVgate)
A post-authorisation non-interventional safety study in patients treated with efgartigimod alfa.
PROGNO-MG
Prospective, multicenter, non-interventional study to identify prognostic biomarkers predicting a highly active disease course in immunotherapy-naïve patients with myasthenia gravis.
ARGX-999-2-MG-2000 (ADAPT FORWARD)
A Master Protocol for an Exploratory, Phase 2a, Proof-of-Concept Platform Study to Evaluate the Safety, Tolerability, and Efficacy of Multiple Regimens in Participants with Myasthenia Gravis. EU-CT: 2025-522492-28.
GENERATE-BOOST
A multicentre, randomized, controlled and double-blind study to evaluate the efficacy and safety of bortezomib in patients with severe autoimmune encephalitis. EudraCT: 2019-001423-12.
Interdisciplinary Collaboration
Many clinical trials require close collaboration among various medical disciplines. We maintain strong interdisciplinary collaborations within the University Hospital Würzburg, including Neuroradiology, Nuclear Medicine, Ophthalmology, and the Central Laboratory. This enables the efficient implementation of complex and interdisciplinary study protocols.
Study team
Our study team consists of medical and non-medical study coordinators as well as six experienced study nurses. Clinical trials are supervised by dedicated principal investigators and physicians from the respective neurological subspecialties.
Sponsor & CRO Information
The Clinical Trial Unit Neurology is an experienced and reliable partner for academic and industry-sponsored clinical research in neurological diseases. Established structures and well-defined processes ensure efficient, transparent, and GCP-compliant trial conduct.
Comprehensive support throughout the entire course of study
We guide research projects from initial planning through to successful completion and provide support in areas such as:
- feasibility assessments
- study start-up processes
- contract management including tracking
- budget review
- patient recruitment
- conduct of national and international multicenter clinical trials
Experience with IITs and medical device testing
In addition to industry-sponsored research, we have extensive experience in the design, planning, and conduct of investigator-initiated trials (IITs). In particular, we possess longstanding expertise in clinical investigations of medical devices, including study design, regulatory coordination, and operational trial management.
Quality-Assured Study Processes
Our processes are fully GCP-compliant and supported by structured workflows in study management, contract and budget administration, and study coordination. Close integration with clinical and diagnostic units enables efficient trial execution from feasibility to study completion.
Contact for Feasibility & Sponsor/CRO Inquiries
Christine Leypold
Email: Leypold_C@ukw.de
Phone: +49 931 201-23510
Fax: +49 931 201-23410
Requests are handled in a structured and timely manner, ensuring efficient and compliant study initiation and conduct.