The responsible project members will present each project and first results
Project 6 investigates the mechanisms of presynaptic plasticity and the reorganization of nociceptive terminals in the skin. An established mouse skin-nerve preparation and genetically modified Drosophila models are used to analyze the role of specific genes and signaling pathways in pain processing. The aim is to better understand how peripheral stimuli contribute to the persistence of chronic pain.
Further information on Project 6
Project 7 focuses on the role of the blood-brain and blood-nerve barriers in chronic pain. The project examines the reversible opening of these barriers after nerve injury and its relevance for central sensitization and pain chronification, particularly in complex regional pain syndrome (CRPS).