Publications of the KFO 5001

Acharya N, Wiesel E, Selcho M, Ehmann N, Lamberty M, Hansson BS, Wicher D, Kittel RJ. Type-specific molecular signaling architectures and synaptic plasticity of Drosophila olfactory sensory neurons. Front Cell Neurosci. 2025 Aug 26;19:1579821. PMID: 40933858; PMCID: PMC12417400.
doi: 10.3389/fncel.2025.1579821

Appeltshauser L, Moritz CP, Reinhardt L, Kreß L, Üçeyler N, Lassablière F, Barcic A, Seefried S, Sommer C, Tholance Y, Antoine JC, Camdessanché JP, Doppler K. Inter-laboratory comparison of a serum fibroblast growth factor receptor 3 (FGFR3) antibody test in sensory neuropathies. Front Immunol. 2025 Oct 10;16:1604456. PMID: 41142778; PMCID: PMC12549695.
doi: 10.3389/fimmu.2025.1604456

Atalla MS, Bettenhausen AL, Verse JM, Cebulla N, Krug SM, Sauer RS, Srivastava M, Bischler T, Chen JTC, Kortüm KM, Kittel RJ, Sommer C, Rittner HL. Neuronal toxicity and recovery from early bortezomib-induced neuropathy: blood-nerve barrier dysfunction without dorsal root ganglion damage. Br J Anaesth. 2025 Aug 1:S0007-0912(25)00366-6. Epub ahead of print. PMID: 40753003.
doi: 10.1016/j.bja.2025.05.046

Biesold A, Burkard P, Rawat A, Cyran L, Meybohm P, Rittner H, Briese M, Wagner NM. Neutrophil dynamics in surgical wounds - A novel role of interleukin-7. Neurobiol Pain. 2025 Sep 21;18:100199. PMID: 41080189; PMCID: PMC12508816.
doi: 10.1016/j.ynpai.2025.100199

Chen J, Jammoul M, Reinhold AK, Becker J, Harnik M, Tivarus M, Homola GA, Schindehütte M, Hein G, Sommer C, Pham M, Rittner HL, Geha P. Resting-State Brain Activity in Acute and Chronic Complex Regional Pain Syndrome. Eur J Neurosci. 2025 Aug;62(3):e70220. PMID: 40799147.
doi: 10.1111/ejn.70220

Habib M, Wiessler AL, Fischer P, Niesner M, Selcho M, Abrante L, Werner C, Sodmann A, Koch M, Zare A, Prüss H, Dargvainiene J, Lewerenz J, Handreka R, Körtvelyessy P, Reinhold D, Thaler FS, Pitarokoili K, Kittel RJ, Briese M, Sendtner M, Rittner H, Leypoldt F, Sommer C, Blum R, Doppler K, Villmann C. Neuropathic Pain and Distinct CASPR2 Autoantibody IgG Subclasses Drive Neuronal Hyperexcitability. Neurol Neuroimmunol Neuroinflamm. 2025 Jul;12(4):e200423. Epub 2025 Jun 25. PMID: 40561371; PMCID: PMC12202018.
doi: 10.1212/NXI.0000000000200423

Herrmann E, Schindehütte M, Kindl G, Reinhold AK, Aulbach F, Rose N, Dreiling J, Schwarzkopf D, Meir M, Jin Y, Teichmüller K, Widder A, Blum R, Sawalma A, Cebulla N, Sendtner M, Meissner W, Brack A, Pham M, Sommer C, Schlegel N, Rittner HL. Chronic postsurgical inguinal pain: incidence and diagnostic biomarkers from a large German national claims database. Br J Anaesth. 2025 Jun;134(6):1746-1755. Epub 2025 Feb 4. PMID: 39909798; PMCID: PMC12106889.
doi: 10.1016/j.bja.2024.11.048

Jin Y, Aravamudhan A, Cebulla N, Schirmer D, Runau E, Flamm L, Terhorst C, Jähnel L, Güse J, Giordani N, Wieser A, Sodmann A, Blum R, Kittel RJ, Sommer C. Diminished transient receptor vanilloid 1 on skin nerve fibers in painful bortezomib-induced peripheral neuropathy. Pain. 2025 Nov 1;166(11):2657-2667. Epub 2025 Jul 7. PMID: 40623269.
doi: 10.1097/j.pain.0000000000003709

Koch M, Kshirsagar M, Rawat A, Zare A, Schlott F, Bischler T, Arampatzi P, Briese M, Sendtner M. NGF stimulation alters the transcriptome and surface TrkB expression in axons of dorsal root ganglion neurons. Neurobiol Pain. 2025 Aug 5;18:100194. PMID: 40823647; PMCID: PMC12355597.
doi: 10.1016/j.ynpai.2025.100194

Meller E, Amann A, Malik RA, Kampik D, Matthies C, Üçeyler N. Clinical characterization of neuropathic pain and small fiber impairment in neurofibromatosis. Pain Rep. 2025 May 6;10(3):e1285. PMID: 40342626; PMCID: PMC12058648.
doi: 10.1097/PR9.0000000000001285

Nauroth-Kreß AC, Weiner S, Hölzli L, Kampf T, Homola GA, Pham M, Kollmannsberger P, Schindehütte M. Automated segmentation of the dorsal root ganglia in MRI. Neuroimage. 2025 May 1;311:121189. Epub 2025 Apr 2. PMID: 40185423.
doi: 10.1016/j.neuroimage.2025.121189

Rawat A, Vu DT, Erbacher C, Stigloher C, Üçeyler N, Metousis A, Mann M, Briese M, Sendtner M. Proteomic analysis of isolated nerve terminals from NaV1.9 knockout mice reveals pathways relevant for pain perception. Pain. 2025 Jul 29;166(12):e770–87. Epub ahead of print. PMID: 40719881; PMCID: PMC12617664.
doi: 10.1097/j.pain.0000000000003743

Rodriguez-Rozada S, Tovote P. Central regulation of cardio-behavioral responses: Circuit engagement during aversive emotional states. Curr Opin Neurobiol. 2025 Oct;94:103105. Epub 2025 Aug 28. PMID: 40882384.
doi: 10.1016/j.conb.2025.103105

Schindehütte M, Meller E, Kampf T, Hessenauer F, Üçeyler N, Homola G, Rittner HL, Matthies C, Pham M, Weiner S. Quantitative MRI of dorsal root ganglion alterations in neurofibromatosis type 1 patients with or without pain. Eur Radiol Exp. 2025 May 28;9(1):57. PMID: 40437318; PMCID: PMC12119455.
doi: 10.1186/s41747-025-00594-x

Seefried S, Barcic A, Grijalva Yepez MF, Reinhardt L, Appeltshauser L, Doppler K, Üçeyler N, Sommer C. Autoantibodies in patients with fibromyalgia syndrome. Pain. 2025 Feb 5;166(8):1922-1933. PMID: 39907533.
doi: 10.1097/j.pain.0000000000003535

Weigel J, Appeltshauser L, Sommer C, Doppler K. Proprioceptive endings at muscle spindles as a possible target of autoantibodies. J Neuroimmunol. 2025 Aug 15;405:578648. Epub 2025 May 21. PMID: 40424942.
doi: 10.1016/j.jneuroim.2025.578648

Weiner S, Perleth S, Kampf T, Lau K, Hessenauer F, Homola G, Nordbeck P, Üçeyler N, Sommer C, Pham M, Schindehütte M. MRI T2 Mapping of Dorsal Root Ganglia Reveals Increased T2 Relaxation Time in Classical Fabry Disease. Biomedicines. 2025 Feb 28;13(3):592. PMID: 40149569; PMCID: PMC11940213.
doi: 10.3390/biomedicines13030592

Weiner S, Perleth S, Schäfer Gómez C, Kampf T, Lau K, Hessenauer F, Homola G, Nordbeck P, Üçeyler N, Sommer C, Pham M, Schindehütte M. Proton Density of the Dorsal Root Ganglia in Classical Fabry Disease: MRI Correlates of Small Fibre Neuropathy. Biomedicines. 2025 Jun 13;13(6):1468. PMID: 40564187; PMCID: PMC12191292.
doi: 10.3390/biomedicines13061468

Widder A, Bucher H, Reinhold AK, Maroske L, Meyer T, Wiegering A, Lock JF, Germer C-, Rittner HL, Schlegel N, Meir M. Chronic postoperative inguinal pain (CPIP) after pediatric inguinal hernia repair-a retrospective analysis. Hernia. 2025 Jan 6;29(1):62. PMID: 39757332; PMCID: PMC11700912.
doi: 10.1007/s10029-024-03245-z

Appeltshauser L, Glenewinkel H, Rohrbacher S, Wessely L, Villmann C, Sommer C, Doppler K.
Case report: target antigen and subclass switch in a patient with autoimmune nodopathy.
Front Immunol. 2024 Oct 7;15:1475478
doi:10.3389/fimmu.2024.1475478

Breyer M, Grüner J, Klein A, Finke L, Klug K, Sauer M, Üçeyler N (2024)
In vitro characterization of cells derived from a patient with the GLA variant c.376A>G (p.S126G) highlights a non-pathogenic role in Fabry disease.
Molecular Genetics and Metabolism Reports 2024 Mar, 38: 101029
Zur Publikation

Bullmann T, Kaas T, Ritzau-Jost A, Wöhner A, Kirmann T, Rizalar FS, Holzer M, Nerlich J, Puchkov D, Geis C, Eilers J, Kittel RJ, Arendt T, Haucke V, Hallermann S.
Human iPSC-Derived Neurons with Reliable Synapses and Large Presynaptic Action Potentials.
J Neurosci. 2024 Jun 12;44(24):e0971232024
doi:10.1523/JNEUROSCI.0971-23.2024

Greguletz P, Plötz M, Baade-Büttner C, Bien CG, Eisenhut K, Geis C, Handreka R, Klausewitz J, Körtvelyessy P, Kovac S, Kraft A, Lewerenz J, Malter M, Nagel M, von Podewils F, Prüß H, Rada A, Rau J, Rauer S, Rößling R, Seifert-Held T, Siebenbrodt K, Sühs KW, Tauber SC, Thaler F, Wagner J, Wickel J, Leypoldt F, Rittner HL, Sommer C, Villmann C, Doppler K (2024)
GENERATE study group. Different pain phenotypes are associated with anti-Caspr2 autoantibodies.
Journal of Neurology 2024 May; 271(5): 2736-2744
Zur Publikation

Habib M, Wiessler A-L, Greguletz P, Niesner M, Selcho M, Abrante L, Werner C, Sodmann A, Koch M, Abdelhossein Z, Pruess H, Dargvainiene J, Lewerenz J, Handreka R, Koertvelyessy P, Reinhold D, Thaler F, Pitarokoili K, Kittel R, Briese M, Sendtner M, Rittner H, Leypoldt F, Sommer C, Blum R, Doppler K, Villmann C.
Neuropathic pain and distinct CASPR2 autoantibody IgG subclasses drive neuronal hyperexcitability.
bioRxiv: 2024, 2024.2009.2004.611282
doi: 10.1101/2024.09.04.611282

Harnik MA, Sodmann A, Hartmannsberger B, Kindl G, Becker J, Reinhold AK, Herrmann E, Buck AK, Dischinger U, Birklein F, Brack A, Sawalma A, Rittner HL. Bone metabolism in complex regional pain syndrome. Pain Rep. 2024 Nov 20;9(6):e1217. PMID: 39574486; PMCID: PMC11581760.
doi: 10.1097/PR9.0000000000001217

Hartmannsberger B, Ben-Kraiem A, Kramer S, Guidolin C, Kazerani I, Doppler K, Thomas D, Gurke R, Sisignano M, Kalelkar PP, García AJ, Monje PV, Sammeth M, Nusrat A, Brack A, Krug SM, Sommer C, Rittner HL. TAM receptors mediate the Fpr2-driven pain resolution and fibrinolysis after nerve injury. Acta Neuropathol. 2024 Dec 16;149(1):1. PMID: 39680199; PMCID: PMC11649718.
doi:10.1007/s00401-024-02840-9

Hartmannsberger B, Scriba S, Guidolin C, Becker J, Mehling K, Doppler K, Sommer C, Rittner HL (2024)
Transient immune activation without loss of intraepidermal innervation and associated Schwann cells in patients with complex regional pain syndrome.
Journal of Neuroinflammation 2024 Jan 17; 21(1): 23
Zur Publikation

Herrmann E, Schindehuette M, Kindl G, Reinhold A-K, Aulbach F, Rose N, Dreiling J, Schwarzkopf D, Meir M, Jin Y, Teichmueller K, Widder A, Blum R, Sawalma A, Cebulla N, Sendtner M, Meissner W, Brack A, Pham M, Sommer C, Schlegel N, Rittner HL.
Dorsal root ganglia atrophy and serum biomarkers supporting the diagnosis of chronic postsurgical inguinal pain.
medRxiv: 2024, 2024.06.18.24309141
doi:https://doi.org/10.1101/2024.06.18.24309141 

Jin Y, Brennecke J, Sodmann A, Blum R, Sommer C.
Antibody selection and automated quantification of TRPV1 immunofluorescence on human skin.
Sci Rep. 2024 Nov 18;14(1):28496
doi: 10.1038/s41598-024-79271-9
 
Klein T, Grüner J, Breyer M, Schlegel J, Schottmann NM, Hofmann L, Gauss K, Mease R, Erbacher C, Finke L, Klein A, Klug K, Karl-Schöller F, Vignolo B, Reinhard S, Schneider T, Günther K, Fink J, Dudek J, Maack C, Klopocki E, Seibel J, Edenhofer F, Wischmeyer E, Sauer M, Üçeyler N (2024)
Small fibre neuropathy in Fabry disease: a human-derived neuronal in vitro disease model and pilot data.
Brain Communications 2024 Apr 3; 6(2).
Zur Publikation

Klein A, Klug K, Breyer M, Grüner J, Medala VK, Nordbeck P, Wanner C., Klopocki E, Üçeyler N (2024)
Genetic variants of unknown significance in alpha-galactosidase A: Cellular delineation from Fabry disease.
Journal of Inherited Metabolism Disease 2024 Apr 15; Online ahead of print
Zur Publikation

Krug SM, Fromm M. Special Issue "The Tight Junction and Its Proteins: From Structure to Pathologies". Int J Mol Sci. 2024 Dec 7;25(23):13154. PMID: 39684864; PMCID: PMC11642033.
doi: 10.3390/ijms252313154

Mehling K, Becker J, Chen J, Scriba S, Kindl G, Jakubietz R, Sommer C, Hartmannsberger B, Rittner HL (2024)
Bilateral deficiency of Meissner corpuscles and papillary microvessels in patients with acute complex regional pain syndrome.
Pain 2024 Feb 7; 10.1097; Epub. ahead of print
Zur Publikation

Rohrbacher S, Seefried S, Hartmannsberger B, Annabelle R, Appeltshauser L, Arlt FA, Brämer D, Dresel C, Dorst J, Elmas Z, Franke C, Geis C, Högen T, Krause S, Marziniak M, Mäurer M, Prüss H, Schoeberl F, Schrank B, Steen C, Teichtinger H, Thieme A, Wessely L, Zernecke A, Sommer C, Doppler K.
Different Patterns of Autoantibody Secretion by Peripheral Blood Mononuclear Cells in Autoimmune Nodopathies.
Neurol Neuroimmunol Neuroinflamm. 2024 Sep;11(5):e200295.
doi: 10.1212/NXI.0000000000200295. Epub 2024 Aug 22.
Erratum in: Neurol Neuroimmunol Neuroinflamm. 2024 Nov;11(6):e200330
doi: 10.1212/NXI.0000000000200330

Schindehütte M, Weiner S, Klug K, Hölzli L, Nauroth-Kreß C, Hessenauer F, Kampf T, Homola GA, Nordbeck P, Wanner C, Sommer C, Üçeyler N, Pham M.
Dorsal root ganglion magnetic resonance imaging biomarker correlations with pain in Fabry disease.
Brain Commun. 2024 May 1;6(3):fcae155.
doi: 10.1093/braincomms/fcae155

Sodmann A, Degenbeck J, Aue A, Schindehütte M, Schlott F, Arampatzi P, Bischler T, Schneider M, Monoranu CM, Gräfenhan T, Bohnert M, Pham M, Antoniadis G, Blum R, Rittner HL.
Molecular and cellular processes of deafferentation after plexus injury in human dorsal root ganglia.
Research Square: 2024
doi:10.21203/rs.3.rs-3997024/v1

Sodmann A, Degenbeck J, Aue A, Schindehütte M, Schlott F, Arampatzi P, Bischler T, Schneider M, Brack A, Monoranu CM, Gräfenhan T, Bohnert M, Pham M, Antoniadis G, Blum R, Rittner HL. Human dorsal root ganglia are either preserved or completely lost after deafferentation by brachial plexus injury. Br J Anaesth. 2024 Dec;133(6):1250-1262. Epub 2024 Oct 11. PMID: 39393999; PMCID: PMC11589459.
doi: 10.1016/j.bja.2024.09.004

Sodmann A, Koehler N, Esfahani NM, Schuhkraft N, Aue A, Jager SE, Bischler T, Imdahl F, Graefenhan T, Leipold E, Rittner HL, Blum R.
Satellite glial cells from adult DRG dedifferentiate in vitro and can be reprogrammed into nociceptor-like neurons.
bioRxiv: 2024, 2024.2004.2009.588701
doi:10.1101/2024.04.09.588701

Sommer C, Üçeyler N. Small fiber pathology in fibromyalgia syndrome. Pain Rep. 2024 Dec 24;10(1):e1220. PMID: 39726855; PMCID: PMC11671067.
doi: 10.1097/PR9.0000000000001220

Weiß M, Gründahl M, Jachnik A, Lampe EC, Malik I, Rittner HL, Sommer C, Hein G.
The Effect of Everyday-Life Social Contact on Pain.
J Med Internet Res. 2024 Apr 30;26:e53830
doi: 10.2196/53830​

Appeltshauser L, Doppler K (2023)
Pan-Neurofascin autoimmune nodopathy – a life-threatening, but reversible neuropathy.
Current Opinion in Neurology 2023 Oct 1; 36(5): 394-40
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Cebulla N, Schirmer D, Runau E, Flamm L, Gommersbach S, Stengel H, Zhou X, Einsele H, Reinhold AK, Rogalla von Bieberstein B, Zeller D, Rittner H, Kortüm M, Sommer C (2023)
Neurofilament light chain levels indicate acute axonal damage under bortezomib treatment.
Journal of Neurology 2023 Feb 18; 270(6): 2997-3007
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Chen JT, Hu X, Otto IUC, Schürger C, von Bieberstein BR, Doppler K, Krug SM, Hankir MK, Blasig R, Sommer C, Brack A, Blasig IE, Rittner HL (2023) 
Myelin barrier breakdown, mechanical hypersensitivity, and painfulness in polyneuropathy with claudin-12 deficiency.
Neurobiology of Disease 2023 Jul; 30: 106246
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Griebel M, Segebarth D, Stein N, Schukraft N, Tovote P, Blum R, Flath CM (2023).
Deep learning-enabled segmentation of ambiguous bioimages with deepflash2.
Nature Communications 2023 May 24; 14(1): 2993
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Reinhold AK, Hartmannsberger B, Burek M, Rittner HL (2023)
Stabilizing the neural barrier – A novel approach in pain therapy.
Pharmacology and Therapeutics 2023 Sep; 249: 108484
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Rozenfeld E, Ehmann N, Manoim JE, Kittel RJ, Parnas M (2023)
Homeostatic synaptic plasticity rescues neural coding reliability.
Nature Communications 2023 May 24; 14(1): 2993
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Schulte A, Lohner H, Degenbeck J, Segebarth D, Rittner HL, Blum R, Aue A (2023)
Unbiased analysis of the dorsal root ganglion after peripheral nerve injury: no neuronal loss, no gliosis, but satellite glial cell plasticity.
Pain 2023 Apr 1; 164(4) 728-740
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Weichard I, Taschenberger H, Gsell F, Bornschein G, Ritzau-Jost A, Schmidt H, Kittel RJ, Eilers J, Neher E, Hallermann S, Nerlich J (2023)
Fully-primed slowly-recovering vesicles mediate presynaptic LTP at neocortical neurons.
Proceedings of the National Academy of Sciences (PNAS) 2023 Oct 24; 120 (43): 2017
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Widder A, Reese L, Lock JF, Wiegering A, Germer CT, Kindl GK, Rittner HL, Dietz U, Doerfer J, Schlegel N, Meir M (2023)
Postoperative Analgesics Score as a Predictor of Chronic Postoperative Inguinal Pain After Inguinal Hernia Repair: Lessons Learned From a Retrospective Analysis.
World Journal of Surgery 2023 May 29; 47: 2436–2443
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Zhou X, Besse A, Peter J, Steinhardt MJ, Vogt C, Nerreter S, Teufel E, Stanojkovska E, Xiao X, Hornburger H, Haertle L, Lopez MM, Munawar U, Riedel A, Han S, Maurits E, Overkleeft HS, Florea B, Einsele H, Kortüm KM, Driessen C, Besse L, Rasche L (2023)
High-dose carfilzomib achieves superior anti-tumor activity over low-dose and recaptures response in relapsed/refractory multiple myeloma resistant to lowdose carfilzomib by co-inhibiting the β2 and β1 subunits of the proteasome complex.
Haematologica 2023 Jun 1; 108(6): 1628-1639
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Zhou X, Han S, Cebulla N, Haertle L, Steinhardt MJ, Schirmer D, Runau E, Flamm L, Terhorst C, Jähnel C,  Vogt C, Nerreter S, Teufel E, Stanojkovska E, Mersi J,  Munawar U, Schindehütte M, Blum R, Reinhold AK,   Scherf-Clavel O, Rittner HL, Pham M, Rasche L, Einsele H, Sommer C, Kortüm M (2023)
Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1.
Biomarker Research 2023 May 16; 11(1): 52
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Becker J, Papagianni A, Herrmann E, Nöller F, Sommer C, Rittner HL (2022)
Transient hypoalgesia after COVID-19 infection.
Pain Reports 2022 Mar 11; 7(2): e990
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Reinhold AK, Kindl GK, Dietz C, Scheu N, Mehling K, Brack A, Birklein F, Rittner HL (2022)
Molecular and clinical markers of pain relief in complex regional pain syndrome: An observational study.
European Journal of Pain 2023 Feb; 27(2): 278-288
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Reinhold AK, Krug SM, Salvador E, Sauer RS, Karl-Schöller F, Malcangio M, Sommer C, Rittner HL (2022)
MicroRNA-21-5p functions via RECK/MMP9 as a proalgesic regulator of the blood nerve barrier in nerve injury.
Annals of the New York Academy of Sciences 2022 Sep; 1515(1): 184-195
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Reinhold AK, Salvador E, Förster CY, Birklein F, Rittner HL (2022)
Microvascular Barrier Protection by microRNA-183 via FoxO1 Repression: A Pathway Disturbed in Neuropathy and Complex Regional Pain Syndrome.
The Journal of Pain 2022 Jun; 23(6): 967-980
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Teichmüller K, Bast L, Rittner HL, Kindl G (2022)
Chronische Schmerzen im Seniorenalter vor dem Hintergrund der COVID-19- Pandemie.
Der Schmerz 2022 Dec; 36(6): 429-436
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Weiß F, Czichos C, Knobe L, Voges L, Bojarski C, Michel G, Fromm M, Krug SM (2022)
MarvelD3 Is Upregulated in Ulcerative Colitis and Has Attenuating Effects during Colitis Indirectly Stabilizing the Intestinal Barrier.
Cells 2022 May 4; 11(9):1541
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Essig F, Kollikowski AM, Müllges W, Stoll G, Haeusler KG, Schuhmann MK, Pham M (2021)
Local Cerebral Recombinant Tissue Plasminogen Activator Concentrations During Acute Stroke.
JAMA Neurology 2021 May 1; 78(5): 615-617 
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Oehler B, Brack A, Blum R, Rittner HL (2021)
Pain Control by Targeting Oxidized Phospholipids: Functions, Mechanisms, Perspectives.
Frontiers in Endocrinology 2021 Jan 25; 11: 613868
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Rozenfeld E, Ehmann N, Manoim JE, Kittel RJ, Parnas M (2023)
Homeostatic synaptic plasticity rescues neural coding reliability.
Nature Communications 2023 May 24; 14(1): 2993
Go to publication