Mitochondrial Metabolism in leukocytes (B5)

This project aims to uncover the role of dynamic changes in mitochondrial metabolism and phospholipids in controlling the response of macrophages and T-cells to myocardial infarction (MI). The contribution of immune cell metabolism and its impact on their differentiation and effector function in MI remains elusive. A better mechanistic understanding of how structural changes in mitochondria shape inflammatory immune responses will open novel therapeutic avenues for treating immunopathology after MI.