Human neuronal cell models

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We are especially interested in the research of  neurodevelopmental psychiatric disorders with a focus on ADHD (attention-deficit-/hyperactivity disorder) and affective disorders (bipolar affectiv disorders) using human derived cell models.

Aims and research areas

We investigate cellular mechanisms of genetic variants associated with mental illness. As a human cell model, we use neuronal cells redifferentiated from induced pluripotent stem cells. We use skin samples, hair follicles or blood as starting tissue. On the one hand, we compare molecular processes in cells of patients with ADHD and Bipolar Affective Disorder with or without certain genetic variants in order to identify their molecular consequences in the respective patient group. And secondly, we compare molecular processes in cells from patients and subjects with the same genetic variant to identify their molecular consequences in different groups. In further studies, we are investigating the effect of drugs on the altered molecular processes.




Research associates

  • Dr. med. Matthias Nieberler
  • Dr. med. Franziska Radtke (KJP)
  • PhD Candidate Zora Schickardt


  • Nicole Döring

Current projects

  • IZKF Projekt
    Dr. Rhiannon McNeill
    Further information can be found here.
  • IZKF Bridging Programm
    Dr. med. Franziska Radtke
    Further information can be found here.
  • NARSAD Young Investigator Grant (Brain and Behaviour Research Foundation)
    Dr. Rhiannon McNeillFurther information can be found here.
    Dr. Georg ZieglerFurther information can be found here.


Publications of the working group can be found on pubmed (Dr. McNeill), on pubmed (Dr. Ziegler) or in the list of publications of our hospital.

Head of Hospital

Dr. rer. nat.
Rhiannon McNeill

Head of laboratory: human cell models of mental disorder