Human cell models of mental disorder

We are especially interested in the research of  neurodevelopmental psychiatric disorders with a focus on ADHD (attention-deficit-/hyperactivity disorder) and affective disorders (bipolar disorder and major depression) using human derived cell models.

Aims and research areas

We investigate cellular pathomechanisms of mental disorders and are interested in identifying cellular drug response and non response mechanisms. A technique we apply in our lab to reach those aims is the generation of neuronal cell models via induced-pluripotent stem cells, which we reprogram from skin punches from our patients. Thereby, we will model disease development, gene-environment-development interaction and drug response mechanisms in the cell culture dish to gain insight for novel diagnostic, prevention and therapy options.

Team

Head

Dr. rer. nat. Rhiannon McNeill
E-mail: mcneill_r@ ukw.de

Team cell culture lab

• Dr. med. Matthias Nieberler
• Dr. med. Franziska Radtke (KJP)
• PhD Candidate Zora Schickardt

Technician

• Nicole Döring

Publications

Publications of the working group can be found on pubmed or in the list of publications of our hospital.