Personalized therapy for affective disorders

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Research areas

Affective disorders including Major depressive disorder and Bipolar affective disorder are highly prevalent mental diseases with highest rates of disability. Very often affective disorders are accompanied by somatic diseases (e.g. cardiovascular or neurological diseases). The standard therapeutic procedures are still not adequately effective. One reason for this is that our knowledge on biological pathways of mental disorders is not yet sufficient. Moreover, the associations of mental disorders with medical comorbidities is still not well-known. One main issue is the lack of individualized treatment options.

Due to a favourable probability of therapeutic success by an antidepressant treatment in general, but rather low antidepressant response rates, individualized treatment strategies are essential.  

The research group focuses on personalized treatment strategies in patients with affective disorders. Therefore, pharmacogenetic analyses of the individual metabolic function (CYP2D6, CYP2C19) and Therapeutic Drug Monitoring with determination of serum concentration of antidepressant drugs and other psychopharmacological agents are used to individualize psychopharmacological treatment (PD Dr. Weber, Prof. Dr. Unterecker).



Scientific cooperation partner

Research associates

Study Nurse

Current projects

  • P4D
    Further information can be found here.
  • UTN
    Further information can be found here.
  • theta Burst
    Further information can be found here
    Further information can be found here.
    Further information can be found here.


Publications of the working group can be found on pubmed and in the list of publications of our hospital.

Head of Hospital

Portraitfoto von PD Dr. med. Dipl.-Psych. Stefan Unterecker

Prof. Dr. med. Dipl.-Psych.
Stefan Unterecker

Medical director for clinical psychology and chief consultant

+49 931 201-77545