Neuroscience of psychomotor function

Please click here for the German version.

Research area

Psychomotor behavior is altered in multiple mental disorders. Aberrant psychomotor behaviors can manifest as subtle changes in coordination and movement control, generalized slowing, repetitive involuntary movements, or complex disturbances in sequencing of movement patterns. Some of these psychomotor abnormalities are very clearly recognizable, while others require sensitive instrumentation. Clinically, catatonia syndrome is of particular importance. Abnormalities in psychomotor function hold valuable information, indicating the onset of disorders or an unfavorable course. At the same time, an amelioration of psychomotor abnormalities is often the first visible sign of treatment effects. Brain areas and networks involved in motor control are significantly altered in some mental disorders, introducing various opportunities for specific intervention.

Methods

We use clinical scales, video recordings, behavioral experiments, and sensors to assess changes in psychomotor activity. To investigate the brain networks involved, we use functional and structural brain imaging as well as motor-evoked potentials. In addition, we examine whether non-invasive brain stimulation methods such as repetitive transcranial magnetic stimulation or other non-pharmacological interventions may alleviate symptoms.

Goals

Our goal is assess psychomotor behaviors precisely and use this knowledge to make predictions. In addition, we aim at better understanding the neural basis of psychomotor abnormalities in order to develop targeted treatments. Our findings will improve psychiatric diagnostics and optimize the treatment of mental disorders.

Team

Prof. Dr. med. Sebastian Walther
Tel.: +49 931 201-77000
E-Mail: Walther_S5@ ukw.de
Stephanie Lefebvre, PhD
E-Mail: Lefebvre_S@ ukw.de
Mira Semmelroch
E-Mail: Semmelroch_M@ ukw.de
Dr. med. Maximilian Friedrich
E-Mail: Friedrich_M6@ ukw.de
Camille Serquet
E-Mail:
Michael von Broen
E-Mail: Broen_M@ ukw.de