Pharmacogenetics for personalized pharmacotherapy

The efficacy of drugs varies from person to person. For the best individual selection of a psychotropic drug and its optimal dosage, the Department of Psychiatry, Psychosomatics and Psychotherapy at the University Hospital of Würzburg offers genotyping of CYP2D6 and CYP2C19. These influence the metabolism of various psychotropic drugs.

Why genotyping?

People react differently to drugs. In addition to individual factors, for example age, gender, weight, smoking status, or concomitant medication, genetic characteristics also play a decisive role. The two genes CYP2D6 and CYP2C19 form enzymes that strongly drug metabolism. Variants in these genes give rise to variants in the enzymes with different activity. Accordingly, ingested active ingredients are metabolized rapidly, normally or slowly. Therefore, the dosage or the selection of a drug should be based on the individual genetic predisposition in order to avoid over- or underdosing and to ensure a constant level of the active drug.

Determination of CYP genes

In our pharmacogenetic laboratory, we determine the CYP2D6 and CYP2C19 genes and their variants. From this, it can be deduced whether the intended psychotropic drug is suitable for a patient, how high the dosage should be set and whether side effects have to be expected. The information serves the attending physician as a basis for personalized pharmacotherapy, also taking concomitant medications into account.

Procedure and right of objection

For genotyping, only a blood sample is required as part of a routine blood sampling. The findings are used exclusively for the individualized selection and dosage of drugs. Consent to genotyping can be revoked at any time.
The informed consent form is integrated in the consent form for the respective group of persons.

In-house laboratory for pharmacogenetics (PG laboratory)

In order to enable personalized pharmacotherapy, the Department of Psychiatry, Psychosomatics and Psychotherapy at the University Hospital of Würzburg has set up its own laboratory for pharmacogenetics. The strict requirements of the Gene Diagnostics Act (GenDG) are adhered to. Among other things, this prescribes appropriate counseling and its documentation.

Notes for contracting authorities

For further information on the submission of samples, performance, conditions and costs of a genetic analysis, please refer to PG-Laboratory. There you can download the request form and find further information.

Department Management

Portraitfoto von Prof. Dr. med. Jürgen Deckert

Prof. Dr. med.
Jürgen Deckert

Head of the Department of Psychiatry, Psychosomatics and Psychotherapy

+49 931 201-77000

Portraitfoto von PD Dr. med. Dipl.-Psych. Stefan Unterecker

Prof. Dr. med. Dipl.-Psych.
Stefan Unterecker

Medical director for clinical psychology and chief consultant

+49 931 201-77545

Portrait of PD Dr. biol. hum. Heike Weber

PD Dr. biol. hum.
Heike Weber

Head of functional genomics laboratory

+49 931 201-76403


Mediation and information

Phone: +49 931 201 76050
Fax: +49 931 201-77550


Phone: + 49 931 201-77800
E-Mail: ep_poli@ 

In-patient care
Phone: +49 931 201-76050
E-Mail: ep_poli@ 

Clinic directorate

Prof. Dr. med. Jürgen Deckert

Secretary´s office
Phone: +49 931 201-77010
Fax: : +49 931 201-77020
E-Mail: ps_sekr@ 


Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie des Universitätsklinikums | Margarete-Höppel-Platz 1 | 97080 Würzburg | Deutschland