Pharmacogenetics for personalized pharmacotherapy
Why genotyping?
People respond differently to medicines. In addition to factors such as age, sex, body weight, smoking status and concomitant medication, genetic characteristics can also play an important role.
The CYP2D6 and CYP2C19 genes encode enzymes that have a significant influence on drug metabolism. Genetic variants in these genes can alter enzyme activity, meaning that certain medicines may be metabolised more rapidly or more slowly than usual. This can lead to differences in drug concentrations in the blood and, consequently, in treatment efficacy and tolerability.
Testing for pharmacogenetically relevant genes
At our Pharmacogenetics Laboratory, we analyse selected functional variants of the pharmacogenetically relevant genes CYP2D6 and CYP2C19. The results may provide information about individual drug response and tolerability, as well as potential genetically determined risks, where scientifically established associations are available.
This information can support the treating physician in selecting and dosing suitable medicines, assessing potential interactions with concomitant medication and tailoring pharmacotherapy to the individual patient.
Procedure and right to withdraw consent
For genotyping, only a blood sample is required as part of a routine blood sampling. The findings are used exclusively for the individualized selection and dosage of drugs. Consent to genotyping can be withdrawn at any time.
The informed consent form is integrated in the consent form for the respective group of persons.
In-house laboratory for pharmacogenetics (PGx laboratory)
In order to enable personalized pharmacotherapy, the Department of Psychiatry, Psychosomatics and Psychotherapy at the University Hospital of Würzburg has set up its own laboratory for pharmacogenetics. The strict requirements of the Gene Diagnostics Act (GenDG) are adhered to. Among other things, this prescribes appropriate counseling and its documentation.
Notes for contracting authorities
For further information on the submission of samples, performance, conditions and costs of a genetic analysis, please refer to PG-Laboratory. There you can download the request form and find further information.
Department Management
Dr. med.
Bodo Warrings (Management)
Head of the TDM/PGx laboratory and senior physician
+49 931 201-77810
PD Dr. rer. nat.
Maike Scherf-Clavel
Head of the personalized pharmacotherapy working group
+49 931 201-77260
Contact
Appointment
Policlinic
Phone: + 49 931 201-77800
E-Mail: ep_poli@ukw.de
In-patient care
Phone: +49 931 201-76050
E-Mail: ep_poli@ukw.de
Address
Klinik und Poliklinik für Psychiatrie, Psychosomatik und Psychotherapie des Universitätsklinikums | Margarete-Höppel-Platz 1 | 97080 Würzburg | Deutschland