Publikationen

An dieser Stelle finden Sie ausgewählte Publikationen aus der Experimentellen Biomedizin:

Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A. (2014) Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation 129:598-606.

Hailer A, Grunewald TG, Orth M, Reiss C, Kneitz B, Spahn M, Butt E. (2014) Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration. Oncotarget 5:4144-4153.

Greißel A, Culmes M, Napieralski R, Wagner E, Gebhard H, Schmitt M, Zimmermann A, Eckstein HH, Zernecke A, Pelisek J.(2015) Alternation of histone and DNA methylation in human atherosclerotic carotid plaques. Thromb Haemost 114:390-402.

Chaudhari SM, Sluimer JC, Koch M, Theelen TL, Manthey HD, Busch M, Caballero-Franco C, Vogel F, Cochain C, Pelisek J, Daemen MJ, Lutz MB, Görlach A, Kissler S, Hermanns HM, Zernecke A. (2015) Deficiency of HIF1α in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. Arterioscler Thromb Vasc Biol 35:2316-25.

Cochain C, Koch M, Chaudhari SM, Busch M, Pelisek J, Boon L, Zernecke A. (2015) CD8+ T Cells Regulate Monopoiesis and Circulating Ly6C-high Monocyte Levels in Atherosclerosis in Mice. Circ Res 117:244-53.

Publikationen 2016

Baig AA, Haining EJ, Geuss E, Beck S, Swieringa F, Wanitchakool P, Schuhmann MK, Stegner D, Kunzelmann K, Kleinschnitz C, Heemskerk JW, Braun A, Nieswandt B. (2016) TMEM16F-Mediated Platelet Membrane Phospholipid Scrambling Is Critical for Hemostasis and Thrombosis but not Thromboinflammation in Mice-Brief Report. Arterioscler Thromb Vasc Biol 36(11):2152-2157.

Brandl A, Daum P, Brenner S, Schulz SR, Yap DY, Bösl MR, Wittmann J, Schuh W, Jäck HM. (2016) The microprocessor component, DGCR8, is essential for early B-cell development in mice. Eur J Immunol 46(12):2710-2718.

Chen W, Spitzl A, Mathes D, Nikolaev VO, Werner F, Weirather J, ?piranec K, Röck K, Fischer JW, Kämmerer U, Stegner D, Baba HA, Hofmann U, Frantz S, Kuhn M. (2016) Endothelial Actions of ANP Enhance Myocardial Inflammatory Infiltration in the Early Phase After Acute Infarction. Circ Res 119(2):237-48.

Chillo O, Kleinert EC, Lautz T, Lasch M, Pagel JI, Heun Y, Troidl K, Fischer S, Caballero-Martinez A, Mauer A, Kurz ARM, Assmann G, Rehberg M, Kanse SM, Nieswandt B, Walzog B, Reichel CA, Mannell H, Preissner KT, Deindl E. (2016) Perivascular Mast Cells Govern Shear Stress-Induced Arteriogenesis by Orchestrating Leukocyte Function. Cell Rep 16(8):2197-2207.

Chubanov V, Ferioli S, Wisnowsky A, Simmons DG, Leitzinger C, Einer C, Jonas W, Shymkiv Y, Bartsch H, Braun A, Akdogan B, Mittermeier L, Sytik L, Torben F, Jurinovic V, van der Vorst EP, Weber C, Yildirim ÖA, Sotlar K, Schürmann A, Zierler S, Zischka H, Ryazanov AG, Gudermann T. (2016) Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival. Elife 5.

Göbel K, Pankratz S, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C, Meuth SG. (2016) Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun 7:11626.

Hopp S, Albert-Weissenberger C, Mencl S, Bieber M, Schuhmann MK, Stetter C, Nieswandt B, Schmidt PM, Monoranu CM, Alafuzoff I, Marklund N, Nolte MW, Sirén AL, Kleinschnitz C. (2016) Targeting coagulation factor XII as a novel therapeutic option in brain trauma. Ann Neurol 79(6):970-82.

Kunz M, Wolf B, Schulze H, Atlan D, Walles T, Walles H, Dandekar T. (2016) Non-Coding RNAs in Lung Cancer: Contribution of Bioinformatics Analysis to the Development of Non-Invasive Diagnostic Tools. Genes (Basel) 8:1.

Mattheij NJ, Braun A, van Kruchten R, Castoldi E, Pircher J, Baaten CC, Wülling M, Kuijpers MJ, Köhler R, Poole AW, Schreiber R, Vortkamp A, Collins PW, Nieswandt B, Kunzelmann K, Cosemans JM, Heemskerk JW. (2016) Survival protein anoctamin-6 controls multiple platelet responses including phospholipid scrambling, swelling, and protein cleavage. FASEB J 30(2):727-37.

May F, Krupka J, Fries M, Thielmann I, Pragst I, Weimer T, Panousis C, Nieswandt B, Stoll G, Dickneite G, Schulte S, Nolte MW. (2016) FXIIa inhibitor rHA-Infestin-4: Safe thromboprotection in experimental venous, arterial and foreign surface-induced thrombosis. Br J Haematol 173(5):769-78.

Pachel C, Mathes D, Arias-Loza AP, Heitzmann W, Nordbeck P, Deppermann C, Lorenz V, Hofmann U, Nieswandt B, Frantz S. (2016) Inhibition of Platelet GPVI Protects Against Myocardial Ischemia-Reperfusion Injury. Arterioscler Thromb Vasc Biol 36(4):629-35.

Regn M, Laggerbauer B, Jentzsch C, Ramanujam D, Ahles A, Sichler S, Calzada-Wack J, Koenen RR, Braun A, Nieswandt B, Engelhardt S. (2016) Peptidase inhibitor 16 is a membrane-tethered regulator of chemerin processing in the myocardium. J Mol Cell Cardiol 99:57-64.

Semeniak D, Kulawig R, Stegner D, Meyer I, Schwiebert S, Bösing H, Eckes B, Nieswandt B, Schulze H. (2016) Proplatelet formation is selectively inhibited by collagen type I through Syk-independent GPVI signaling. J Cell Sci 129(18):3473-84.

Stegner D, Popp M, Lorenz V, Wax JK, Gessner JE, Nieswandt B. (2016) Fc?RIIB on liver sinusoidal endothelial cells is essential for antibody-induced GPVI ectodomain shedding in mice. Blood 128(6):862-5.

Stritt S, Nurden P, Favier R, Favier M, Ferioli S, Gotru SK, van Eeuwijk JM, Schulze H, Nurden AT, Lambert MP, Turro E, Burger-Stritt S, Matsushita M, Mittermeier L, Ballerini P, Zierler S, Laffan MA, Chubanov V, Gudermann T, Nieswandt B, Braun A. (2016) Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg(2+) homeostasis and cytoskeletal architecture. Nat Commun 7:11097.

Stritt S, Nurden P, Turro E, Greene D, Jansen SB, Westbury SK, Petersen R, Astle WJ, Marlin S, Bariana TK, Kostadima M, Lentaigne C, Maiwald S, Papadia S, Kelly AM, Stephens JC, Penkett CJ, Ashford S, Tuna S, Austin S, Bakchoul T, Collins P, Favier R, Lambert MP, Mathias M, Millar CM, Mapeta R, Perry DJ, Schulman S, Simeoni I, Thys C, BRIDGE-BPD Consortium , Gomez K, Erber WN, Stirrups K, Rendon A, Bradley JR, van Geet C, Raymond FL, Laffan MA, Nurden AT, Nieswandt B, Richardson S, Freson K, Ouwehand WH, Mumford AD. (2016) A gain-of-function variant in DIAPH1 causes dominant macrothrombocytopenia and hearing loss. Blood 127(23):2903-14.

Trujillo Viera J, El-Merahbi R, Nieswandt B, Stegner D, Sumara G. (2016) Phospholipases D1 and D2 Suppress Appetite and Protect against Overweight. PLoS ONE 11(6):e0157607.

van Eeuwijk JM, Stegner D, Lamb DJ, Kraft P, Beck S, Thielmann I, Kiefer F, Walzog B, Stoll G, Nieswandt B. (2016) The Novel Oral Syk Inhibitor, Bl1002494, Protects Mice From Arterial Thrombosis and Thromboinflammatory Brain Infarction. Arterioscler Thromb Vasc Biol 36(6):1247-53.

Wolf K, Braun A, Haining EJ, Tseng YL, Kraft P, Schuhmann MK, Gotru SK, Chen W, Hermanns HM, Stoll G, Lesch KP, Nieswandt B. (2016)Partially Defective Store Operated Calcium Entry and Hem(ITAM) Signaling in Platelets of Serotonin Transporter Deficient Mice. PLoS ONE 11(1):e0147664.

Publikationen 2015

Alshehri OM, Hughes CE, Montague S, Watson SK, Frampton J, Bender M, Watson SP. (2015) Fibrin activates GPVI in human and mouse platelets. Blood 126(13):1601-8.

Ammar MR, Thahouly T, Hanauer A, Stegner D, Nieswandt B, Vitale N. (2015) PLD1 participates in BDNF-induced signalling in cortical neurons. Sci Rep 5:14778.

Andres O, Schulze H, Speer CP. (2015) Platelets in neonates: central mediators in haemostasis, antimicrobial defence and inflammation. Thromb Haemost 113(1):3-12.

Cherpokova D, Bender M, Morowski M, Kraft P, Schuhmann MK, Akbar SM, Sultan CS, Hughes CE, Kleinschnitz C, Stoll G, Dragone LL, Watson SP, Tomlinson MG, Nieswandt B. (2015) SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice. Blood 125(1):185-94.

Crazzolara R, Maurer K, Schulze H, Zieger B, Zustin J, Schulz AS. (2015) A new mutation in the KINDLIN-3 gene ablates integrin-dependent leukocyte, platelet, and osteoclast function in a patient with leukocyte adhesion deficiency-III. Pediatr Blood Cancer 62(9):1677-9.

Devanathan V, Hagedorn I, Köhler D, Pexa K, Cherpokova D, Kraft P, Singh M, Rosenberger P, Stoll G, Birnbaumer L, Piekorz RP, Beer-Hammer S, Nieswandt B, Nürnberg B. (2015) Platelet Gi protein G?i2 is an essential mediator of thrombo-inflammatory organ damage in mice. Proc Natl Acad Sci U S A 112(20):6491-6.

Drube S, Weber F, Loschinski R, Beyer M, Rothe M, Rabenhorst A, Göpfert C, Meininger I, Diamanti MA, Stegner D, Häfner N, Böttcher M, Reinecke K, Herdegen T, Greten FR, Nieswandt B, Hartmann K, Krämer OH, Kamradt T. (2015) Subthreshold IKK activation modulates the effector functions of primary mast cells and allows specific targeting of transformed mast cells. Oncotarget 6(7):5354-68.

Dütting S, Heidenreich J, Cherpokova D, Amin E, Zhang SC, Ahmadian MR, Brakebusch C, Nieswandt B. (2015) Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets. J Thromb Haemost 13(5):827-38.

Flierl U, Nero TL, Lim B, Arthur JF, Yao Y, Jung SM, Gitz E, Pollitt AY, Zaldivia MT, Jandrot-Perrus M, Schäfer A, Nieswandt B, Andrews RK, Parker MW, Gardiner EE, Peter K. (2015) Phosphorothioate backbone modifications of nucleotide-based drugs are potent platelet activators. J Exp Med 212(2):129-37.

Foster E, Wildner H, Tudeau L, Haueter S, Ralvenius WT, Jegen M, Johannssen H, Hösli L, Haenraets K, Ghanem A, Conzelmann KK, Bösl M, Zeilhofer HU. (2015) Targeted ablation, silencing, and activation establish glycinergic dorsal horn neurons as key components of a spinal gate for pain and itch. Neuron 85(6):1289-304.

Göb E, Reymann S, Langhauser F, Schuhmann MK, Kraft P, Thielmann I, Göbel K, Brede M, Homola G, Solymosi L, Stoll G, Geis C, Meuth SG, Nieswandt B, Kleinschnitz C. (2015) Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation. Ann Neurol 77(5):784-803.

Gros A, Syvannarath V, Lamrani L, Ollivier V, Loyau S, Goerge T, Nieswandt B, Jandrot-Perrus M, Ho-Tin-Noé B. (2015) Single platelets seal neutrophil-induced vascular breaches via GPVI during immune-complex-mediated inflammation in mice.    Blood 126(8):1017-26.

Kraft P, Schuhmann MK, Fluri F, Lorenz K, Zernecke A, Stoll G, Nieswandt B, Kleinschnitz C. (2015) Efficacy and Safety of Platelet Glycoprotein Receptor Blockade in Aged and Comorbid Mice With Acute Experimental Stroke. Stroke    46(12):3502-6.

Lorenz V, Stegner D, Stritt S, Vögtle T, Kiefer F, Witke W, Schymeinsky J, Watson SP, Walzog B, Nieswandt B. (2015) Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization. Blood 125(26):4069-77.

Lowe KL, Finney BA, Deppermann C, Hägerling R, Gazit SL, Frampton J, Buckley C, Camerer E, Nieswandt B, Kiefer F, Watson SP. (2015) Podoplanin and CLEC-2 drive cerebrovascular patterning and integrity during development. Blood 125(24):3769-77.

Lowe KL, Navarro-Núñez L, Bénézech C, Nayar S, Kingston BL, Nieswandt B, Barone F, Watson SP, Buckley CD, Desanti GE. (2015) The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state. Eur J Immunol 45(9):2484-93.

Mammadova-Bach E, Ollivier V, Loyau S, Schaff M, Dumont B, Favier R, Freyburger G, Latger-Cannard V, Nieswandt B, Gachet C, Mangin PH, Jandrot-Perrus M. (2015) Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generation. Blood 126(5):683-91.

Maurer E, Schaff M, Receveur N, Bourdon C, Mercier L, Nieswandt B, Dubois C, Jandrot-Perrus M, Goetz JG, Lanza F, Gachet C, Mangin PH. (2015) Fibrillar cellular fibronectin supports efficient platelet aggregation and procoagulant activity. Thromb Haemost 114(6):1175-88.

Michaelis M, Nieswandt B, Stegner D, Eilers J, Kraft R. (2015) STIM1, STIM2, and Orai1 regulate store-operated calcium entry and purinergic activation of microglia. Glia 63(4):652-63.

Popp M, Thielmann I, Nieswandt B, Stegner D. (2015) Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5). PLoS ONE 10(7):e0133429.

Schuhmann MK, Kraft P, Stoll G, Lorenz K, Meuth SG, Wiendl H, Nieswandt B, Sparwasser T, Beyersdorf N, Kerkau T, Kleinschnitz C. (2015) CD28 superagonist-mediated boost of regulatory T cells increases thrombo-inflammation and ischemic neurodegeneration during the acute phase of experimental stroke. J Cereb Blood Flow Metab 35(1):6-10.

Schwarzenberger C, Sradnick J, Lerea KM, Goligorsky MS, Nieswandt B, Hugo CP, Hohenstein B. (2015) Platelets are relevant mediators of renal injury induced by primary endothelial lesions. Am J Physiol Renal Physiol 308(11):F1238-46.

Sogkas G, Vögtle T, Rau E, Gewecke B, Stegner D, Schmidt RE, Nieswandt B, Gessner JE. (2015) Orai1 controls C5a-induced neutrophil recruitment in inflammation. Eur J Immunol 45(7):2143-53.

Stritt S, Wolf K, Lorenz V, Vögtle T, Gupta S, Bösl MR, Nieswandt B. (2015) Rap1-GTP-interacting adaptor molecule (RIAM) is dispensable for platelet integrin activation and function in mice. Blood 125(2):219-22.

Subramaniam S, Thielmann I, Morowski M, Pragst I, Sandset PM, Nieswandt B, Etscheid M, Kanse SM. (2015) Defective thrombus formation in mice lacking endogenous factor VII activating protease (FSAP). Thromb Haemost 113(4):870-80.

Teng S, Stegner D, Chen Q, Hongu T, Hasegawa H, Chen L, Kanaho Y, Nieswandt B, Frohman MA, Huang P. (2015) Phospholipase D1 facilitates second-phase myoblast fusion and skeletal muscle regeneration. Mol Biol Cell 26(3):506-17.

Verhenne S, Denorme F, Libbrecht S, Vandenbulcke A, Pareyn I, Deckmyn H, Lambrecht A, Nieswandt B, Kleinschnitz C, Vanhoorelbeke K, De Meyer SF. (2015) Platelet-derived VWF is not essential for normal thrombosis and hemostasis but fosters ischemic stroke injury in mice. Blood 126(14):1715-22.

Vögtle T, Cherpokova D, Bender M, Nieswandt B. (2015) Targeting platelet receptors in thrombotic and thrombo-inflammatory disorders. Hamostaseologie 35(3):235-43.

Weider M, Wegener A, Schmitt C, Küspert M, Hillgärtner S, Bösl MR, Hermans-Borgmeyer I, Nait-Oumesmar B, Wegner M. (2015) Elevated in vivo levels of a single transcription factor directly convert satellite glia into oligodendrocyte-like cells. PLoS Genet 11(2):e1005008.

Westbury SK, Turro E, Greene D, Lentaigne C, Kelly AM, Bariana TK, Simeoni I, Pillois X, Attwood A, Austin S, Jansen SB, Bakchoul T, Crisp-Hihn A, Erber WN, Favier R, Foad N, Gattens M, Jolley JD, Liesner R, Meacham S, Millar CM, Nurden AT, Peerlinck K, Perry DJ, Poudel P, Schulman S, Schulze H, Stephens JC, Furie B, Robinson PN, van Geet C, Rendon A, Gomez K, Laffan MA, Lambert MP, Nurden P, Ouwehand WH, Richardson S, Mumford AD, Freson K, BRIDGE-BPD Consortium. (2015) Human phenotype ontology annotation and cluster analysis to unravel genetic defects in 707 cases with unexplained bleeding and platelet disorders. Genome Med 7(1):36.

Publikationen 2014

Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze K, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B. (2014) Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect. Nat Commun 5:4746.

Burkhardt U, Stegner D, Hattingen E, Beyer S, Nieswandt B, Klein J. (2014) Impaired brain development and reduced cognitive function in phospholipase D-deficient mice. Neurosci Lett 572:48-52.

Chen W, Thielmann I, Gupta S, Subramanian H, Stegner D, van Kruchten R, Dietrich A, Gambaryan S, Heemskerk JW, Hermanns HM, Nieswandt B, Braun A. (2014) Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets. J Thromb Haemost 12(4):528-39.

Dénes Á, Pradillo JM, Drake C, Sharp A, Warn P, Murray KN, Rohit B, Dockrell DH, Chamberlain J, Casbolt H, Francis S, Martinecz B, Nieswandt B, Rothwell NJ, Allan SM. (2014) Streptococcus pneumoniae worsens cerebral ischemia via interleukin 1 and platelet glycoprotein Ib?. Ann Neurol 75(5):670-83.

Dütting S, Vögtle T, Morowski M, Schiessl S, Schäfer CM, Watson SK, Hughes CE, Ackermann JA, Radtke D, Hermanns HM, Watson SP, Nitschke L, Nieswandt B. (2014) Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets. Circ Res 114(3):444-53.

Göbel K, Schuhmann MK, Pankratz S, Stegner D, Herrmann AM, Braun A, Breuer J, Bittner S, Ruck T, Wiendl H, Kleinschnitz C, Nieswandt B, Meuth SG. (2014) Phospholipase D1 mediates lymphocyte adhesion and migration in experimental autoimmune encephalomyelitis. Eur J Immunol 44(8):2295-305.

Hess PR, Rawnsley DR, Jakus Z, Yang Y, Sweet DT, Fu J, Herzog B, Lu M, Nieswandt B, Oliver G, Makinen T, Xia L, Kahn ML. (2014) Platelets mediate lymphovenous hemostasis to maintain blood-lymphatic separation throughout life. J Clin Invest 124(1):273-84.

Hillgruber C, Steingräber AK, Pöppelmann B, Denis CV, Ware J, Vestweber D, Nieswandt B, Schneider SW, Goerge T. (2014) Blocking von Willebrand factor for treatment of cutaneous inflammation. J Invest Dermatol 134(1):77-86.

Hofmann S, Braun A, Pozgaj R, Morowski M, Vögtle T, Nieswandt B. (2014) Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis. PLoS ONE 9(12):e115306.

Kraft P, Drechsler C, Gunreben I, Nieswandt B, Stoll G, Heuschmann PU, Kleinschnitz C. (2014) Von Willebrand factor regulation in patients with acute and chronic cerebrovascular disease: a pilot, case-control study. PLoS ONE 9(6):e99851.

Morowski M, Brachs S, Mielenz D, Nieswandt B, Dütting S. (2014) The adaptor protein Swiprosin-1/EFhd2 is dispensable for platelet function in mice. PLoS ONE 9(9):e107139.

Pollitt AY, Poulter NS, Gitz E, Navarro-Nuñez L, Wang YJ, Hughes CE, Thomas SG, Nieswandt B, Douglas MR, Owen DM, Jackson DG, Dustin ML, Watson SP. (2014) Syk and Src family kinases regulate C-type lectin receptor 2 (CLEC-2)-mediated clustering of podoplanin and platelet adhesion to lymphatic endothelial cells. J Biol Chem 289(52):35695-710.

Shida Y, Rydz N, Stegner D, Brown C, Mewburn J, Sponagle K, Danisment O, Crawford B, Vidal B, Hegadorn CA, Pruss CM, Nieswandt B, Lillicrap D. (2014) Analysis of the role of von Willebrand factor, platelet glycoprotein VI-, and ?2?1-mediated collagen binding in thrombus formation. Blood 124(11):1799-807.

Stegner D, Haining EJ, Nieswandt B. (2014) Targeting glycoprotein VI and the immunoreceptor tyrosine-based activation motif signaling pathway. Arterioscler Thromb Vasc Biol 34(8):1615-20.

Stritt S, Thielmann I, Dütting S, Stegner D, Nieswandt B. (2014) Phospholipase D is a central regulator of collagen I-induced cytoskeletal rearrangement and podosome formation in megakaryocytes. J Thromb Haemost 12(8):1364-71.

Suo J, Linke B, Meyer dos Santos S, Pierre S, Stegner D, Zhang DD, Denis CV, Geisslinger G, Nieswandt B, Scholich K. (2014) Neutrophils mediate edema formation but not mechanical allodynia during zymosan-induced inflammation. J Leukoc Biol 96(1):133-42.

Wegener JW, Loga F, Stegner D, Nieswandt B, Hofmann F. (2014) Phospholipase D1 is involved in ?1-adrenergic contraction of murine vascular smooth muscle. FASEB J 28(3):1044-8.

Publikationen 2013

Ammar MR, Humeau Y, Hanauer A, Nieswandt B, Bader MF, Vitale N. (2013) The Coffin-Lowry syndrome-associated protein RSK2 regulates neurite outgrowth through phosphorylation of phospholipase D1 (PLD1) and synthesis of phosphatidic acid. J Neurosci 33(50):19470-9.

Bender M, May F, Lorenz V, Thielmann I, Hagedorn I, Finney BA, Vögtle T, Remer K, Braun A, Bösl M, Watson SP, Nieswandt B. (2013) Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. Arterioscler Thromb Vasc Biol 33(5):926-34.

Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Göbel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, Meuth SG. (2013) Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med 19(9):1161-5.

Herzog BH, Fu J, Wilson SJ, Hess PR, Sen A, McDaniel JM, Pan Y, Sheng M, Yago T, Silasi-Mansat R, McGee S, May F, Nieswandt B, Morris AJ, Lupu F, Coughlin SR, McEver RP, Chen H, Kahn ML, Xia L. (2013) Podoplanin maintains high endothelial venule integrity by interacting with platelet CLEC-2. Nature 502(7469):105-9.

Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Göbel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H. (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121(4):679-91.

Kraft P, Göb E, Schuhmann MK, Göbel K, Deppermann C, Thielmann I, Herrmann AM, Lorenz K, Brede M, Stoll G, Meuth SG, Nieswandt B, Pfeilschifter W, Kleinschnitz C. (2013) FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. Stroke 44(11):3202-10.

Morowski M, Vögtle T, Kraft P, Kleinschnitz C, Stoll G, Nieswandt B. (2013) Only severe thrombocytopenia results in bleeding and defective thrombus formation in mice. Blood 121(24):4938-47.

Pfeiffer V, Götz R, Xiang C, Camarero G, Braun A, Zhang Y, Blum R, Heinsen H, Nieswandt B, Rapp UR. (2013) Ablation of BRaf impairs neuronal differentiation in the postnatal hippocampus and cerebellum. PLoS ONE 8(3):e58259.

Pleines I, Dütting S, Cherpokova D, Eckly A, Meyer I, Morowski M, Krohne G, Schulze H, Gachet C, Debili N, Brakebusch C, Nieswandt B. (2013) Defective tubulin organization and proplatelet formation in murine megakaryocytes lacking Rac1 and Cdc42. Blood 122(18):3178-87.

Schaff M, Tang C, Maurer E, Bourdon C, Receveur N, Eckly A, Hechler B, Arnold C, de Arcangelis A, Nieswandt B, Denis CV, Lefebvre O, Georges-Labouesse E, Gachet C, Lanza F, Mangin PH. (2013) Integrin ?6?1 is the main receptor for vascular laminins and plays a role in platelet adhesion, activation, and arterial thrombosis.    Circulation 128(5):541-52.

Stegner D, Thielmann I, Kraft P, Frohman MA, Stoll G, Nieswandt B. (2013) Pharmacological inhibition of phospholipase D protects mice from occlusive thrombus formation and ischemic stroke--brief report. Arterioscler Thromb Vasc Biol 33(9):2212-7.

Timofeev O, Schlereth K, Wanzel M, Braun A, Nieswandt B, Pagenstecher A, Rosenwald A, Elsässer HP, Stiewe T. (2013) p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell Rep 3(5):1512-25.

Publikationen 2012

Chen Q, Hongu T, Sato T, Zhang Y, Ali W, Cavallo JA, van der Velden A, Tian H, Di Paolo G, Nieswandt B, Kanaho Y, Frohman MA. (2012) Key roles for the lipid signaling enzyme phospholipase d1 in the tumor microenvironment during tumor angiogenesis and metastasis. Sci Signal 5(249):ra79.

Dramane G, Abdoul-Azize S, Hichami A, Vögtle T, Akpona S, Chouabe C, Sadou H, Nieswandt B, Besnard P, Khan NA. (2012) STIM1 regulates calcium signaling in taste bud cells and preference for fat in mice. J Clin Invest 122(6):2267-82.

Dütting S, Bender M, Nieswandt B. (2012) Platelet GPVI: a target for antithrombotic therapy?! Trends Pharmacol Sci 33(11):583-90.

Gupta S, Braun A, Morowski M, Premsler T, Bender M, Nagy Z, Sickmann A, Hermanns HM, Bösl M, Nieswandt B. (2012) CLP36 is a negative regulator of glycoprotein VI signaling in platelets. Circ Res 111(11):1410-20.

Heydenreich N, Nolte MW, Göb E, Langhauser F, Hofmeister M, Kraft P, Albert-Weissenberger C, Brede M, Varallyay C, Göbel K, Meuth SG, Nieswandt B, Dickneite G, Stoll G, Kleinschnitz C. (2012) C1-inhibitor protects from brain ischemia-reperfusion injury by combined antiinflammatory and antithrombotic mechanisms. Stroke 43(9):2457-67.

Hofmann S, Vögtle T, Bender M, Rose-John S, Nieswandt B. (2012) The SLAM family member CD84 is regulated by ADAM10 and calpain in platelets. J Thromb Haemost 10(12):2581-92.

Königsberger S, Prodöhl J, Stegner D, Weis V, Andreas M, Stehling M, Schumacher T, Böhmer R, Thielmann I, van Eeuwijk JM, Nieswandt B, Kiefer F. (2012) Altered BCR signalling quality predisposes to autoimmune disease and a pre-diabetic state. EMBO J 31(15):3363-74.

Kraft P, Nieswandt B, Stoll G, Kleinschnitz C. (2012) Acute ischemic stroke. New approaches to antithrombotic treatment. Nervenarzt 83(4):435-49.

Langer HF, Choi EY, Zhou H, Schleicher R, Chung KJ, Tang Z, Göbel K, Bdeir K, Chatzigeorgiou A, Wong C, Bhatia S, Kruhlak MJ, Rose JW, Burns JB, Hill KE, Qu H, Zhang Y, Lehrmann E, Becker KG, Wang Y, Simon DI, Nieswandt B, Lambris JD, Li X, Meuth SG, Kubes P, Chavakis T. (2012) Platelets contribute to the pathogenesis of experimental autoimmune encephalomyelitis. Circ Res 110(9):1202-10.

Langhauser F, Göb E, Kraft P, Geis C, Schmitt J, Brede M, Göbel K, Helluy X, Pham M, Bendszus M, Jakob P, Stoll G, Meuth SG, Nieswandt B, McCrae KR, Kleinschnitz C. (2012) Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Blood 120(19):4082-92.

Lonsdorf AS, Krämer BF, Fahrleitner M, Schönberger T, Gnerlich S, Ring S, Gehring S, Schneider SW, Kruhlak MJ, Meuth SG, Nieswandt B, Gawaz M, Enk AH, Langer HF. (2012) Engagement of ?IIb?3 (GPIIb/IIIa) with ???3 integrin mediates interaction of melanoma cells with platelets: a connection to hematogenous metastasis. J Biol Chem 287(3):2168-78.

Mazharian A, Wang YJ, Mori J, Bem D, Finney B, Heising S, Gissen P, White JG, Berndt MC, Gardiner EE, Nieswandt B, Douglas MR, Campbell RD, Watson SP, Senis YA. (2012) Mice lacking the ITIM-containing receptor G6b-B exhibit macrothrombocytopenia and aberrant platelet function. Sci Signal 5(248):ra78.

Meyer I, Kunert S, Schwiebert S, Hagedorn I, Italiano JE, Dütting S, Nieswandt B, Bachmann S, Schulze H. (2012) Altered microtubule equilibrium and impaired thrombus stability in mice lacking RanBP10. Blood 120(17):3594-602.

Pham M, Stoll G, Nieswandt B, Bendszus M, Kleinschnitz C. (2012) Blood coagulation factor XII--a neglected player in stroke pathophysiology. J Mol Med 90(2):119-26.

Pleines I, Hagedorn I, Gupta S, May F, Chakarova L, van Hengel J, Offermanns S, Krohne G, Kleinschnitz C, Brakebusch C, Nieswandt B. (2012) Megakaryocyte-specific RhoA deficiency causes macrothrombocytopenia and defective platelet activation in hemostasis and thrombosis. Blood 119(4):1054-63.

Ponnuswamy P, Schröttle A, Ostermeier E, Grüner S, Huang PL, Ertl G, Hoffmann U, Nieswandt B, Kuhlencordt PJ. (2012) eNOS protects from atherosclerosis despite relevant superoxide production by the enzyme in apoE mice. PLoS ONE 7(1):e30193.

Ramanathan G, Gupta S, Thielmann I, Pleines I, Varga-Szabo D, May F, Mannhalter C, Dietrich A, Nieswandt B, Braun A. (2012) Defective diacylglycerol-induced Ca2+ entry but normal agonist-induced activation responses in TRPC6-deficient mouse platelets. J Thromb Haemost 10(3):419-29.

Schönberger T, Ziegler M, Borst O, Konrad I, Nieswandt B, Massberg S, Ochmann C, Jürgens T, Seizer P, Langer H, Münch G, Ungerer M, Preissner KT, Elvers M, Gawaz M. (2012) The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice. Am J Physiol Cell Physiol 303(7):C757-66.

Sodero AO, Vriens J, Ghosh D, Stegner D, Brachet A, Pallotto M, Sassoè-Pognetto M, Brouwers JF, Helms JB, Nieswandt B, Voets T, Dotti CG. (2012) Cholesterol loss during glutamate-mediated excitotoxicity. EMBO J 31(7):1764-73.

Thielmann I, Stegner D, Kraft P, Hagedorn I, Krohne G, Kleinschnitz C, Stoll G, Nieswandt B. (2012) Redundant functions of phospholipases D1 and D2 in platelet ?-granule release. J Thromb Haemost 10(11):2361-72.

van Kruchten R, Braun A, Feijge MA, Kuijpers MJ, Rivera-Galdos R, Kraft P, Stoll G, Kleinschnitz C, Bevers EM, Nieswandt B, Heemskerk JW. (2012) Antithrombotic potential of blockers of store-operated calcium channels in platelets. Arterioscler Thromb Vasc Biol 32(7):1717-23.

Kontakt, Öffnungszeiten, Sprechzeiten

Öffnungszeiten:

Telefon:

Prof. Dr. Bernhard Nieswandt
+49 931 31-80405


Anschrift:

Rudolf-Virchow-Zentrum - DFG-Forschungszentrum für Experimentelle Biomedizin | Lehrstuhl I |
Josef-Schneider-Str. 2 | Haus D15 | 97080 Würzburg | Deutschland