Publikationen

Publikationen 2018

Butt E, Raman D. (2018) New Frontiers for the Cytoskeletal Protein LASP1. Front Oncol 21;8:391. doi:10.3389/fonc.2018.00391.

Cochain C, Ait-Oufella H, Zernecke A. (2018) Neutrophils promote atherosclerotic plaque destabilization in a mouse model of endotoxinaemia. Cardiovasc Res 114(12):1573-1574. doi:10.1093/cvr/cvy168.

Cochain C, Saliba AE, Zernecke A. (2018) Letter in response to “Transcriptome analysis reveals non-foamy rather than foamy plaque macrophages are pro-inflammtory in atherosclerotic murine models”. Circ Res.

Cochain C, Vafadarnejad E, Arampatzi P, Pelisek J, Winkels H, Ley K, Wolf D, Saliba AE, Zernecke A. (2018) Single-Cell RNA-Seq Reveals the Transcriptional Landscape and Heterogeneity of Aortic Macrophages in Murine Atherosclerosis. Circ Res 122(12):1661-1674. doi:10.1161/CIRCRESAHA.117.312509.

Dietrich K, Baumgart J, Eshkind L, Reuter L, Godtel-Armbrust U, Butt E, Musheev M, Marini F, More P, Grosser T, Niehrs C, Wojnowski L, Mathas M. (2018) Health-relevant phenotypes in the offspring of mice given CAR activators prior to pregnancy. Drug Metab Dispos 28. pii:dmd.118.082925. doi:10.1124/dmd.118.082925.

Esser K, Lucifora J, Wettengel J, Singethan K, Glinzer A, Zernecke A, Protzer U. (2018) Lipase inhibitor orlistat prevents hepatitis B virus infection by targeting an early step in the virus life cycle. Antiviral Res 151:4-7. doi:10.1016/j.antiviral.2018.01.001.

Gotru SK, Gil-Pulido J, Beyersdorf N, Diefenbach A, Becker IC, Vögtle T, Remer K, Chubanov V, Gudermann T, Hermanns HM, Nieswandt B, Kerkau T, Zernecke A, Braun A. (2018) Cutting Edge: Imbalanced Cation Homeostasis in MAGT1-Deficient B Cells Dysregulates B Cell Development and Signaling in Mice. J Immunol 200(8):2529-2534. doi: 10.4049/jimmunol.1701467.

Orth MF, Gerke JS, Knösel T, Altendorf-Hofmann A, Musa J, Alba-Rubio R, Stein S, Hölting TLB, Cidrea-Aranaz F, Romero-Pérez L, Dallmayer M, Baldauf MC, Marchetto A, Sannino G, Knott MML, Wehweck F, Ohmura S, Li J, Hakozaki M, Kirchner T, Dandekar T, Butt E, Grünewald TGP. (2018) Functional genomics identifies AMPD2 as a new prognostic marker for undifferentiated pleomorphic sarcoma. Int J Cancer 28. doi:10.1002/ijc.31903.

Rossow L, Veitl S, Vorlová S, Wax JK, Kuhn AE, Maltzahn V, Upcin B, Karl F, Hoffmann H, Gätzner S, Kallius M, Nandigama R, Scheld D, Irmak S, Herterich S, Zernecke A, Ergün S, Henke E. (2018) LOX-catalyzed collagen stabilization is a proximal cause for intrinsic resistance to chemotherapy. Oncogene 37(36):4921-4940. doi:10.1038/s41388-018-0320-2.

Winkels H, Ehinger E, Vassallo M, Buscher K, Dinh HQ, Kobiyama K, Hamers AAJ, Cochain C, Vafadarnejad E, Saliba AE, Zernecke A, Pramod AB, Ghosh AK, Anto Michel N, Hoppe N, Hilgendorf I, Zirlik A, Hedrick CC, Ley K, Wolf D. (2018) Atlas of the Immune Cell Repertoire in Mouse Atherosclerosis Defined by Single-Cell RNA-Sequencing and Mass Cytometry. Circ Res 122(12):1675-1688. doi: 10.1161/CIRCRESAHA.117.312513.

Zernecke A, Seizer P. (2018) Extracellular Matrix Metalloproteinase Inducer EMMPRIN (CD147) in Cardiovascular Disease. von Ungern-Sternberg SNI. Int J Mol Sci 19(2) pii: E507. doi:10.3390/ijms19020507.

Publikationen 2017

Bömmel H, Kleefeldt F, Zernecke A, Ghavampour S, Wagner N, Kuerten S, Ergün S. (2017) Visualization of endothelial barrier damage prior to plaque development. Histoch Cell Biol.

Butt E, Ebbing J, Bubendorf L and Ardelt P. (2017) Influence of haematuria and infection on diagnostic accuracy of urinary LASP1 - a new  biomarker for bladder carcinoma. Biomark. Med 11(4):347-357.

Cochain C, Zernecke A. (2017) Macrophages in vascular inflammation and atherosclerosis. Pflugers Arch doi: 10.1007/s00424-017-1941-y.

Donzelli S, Goetz M, Schmidt K, Wolters M, Stathopoulou K, Diering S, Prysyazhna O, Polat V, Scotcher J, Dees Ch, Subramanian H, Butt E, Kamynina A, Schobesberger S, King B, Nikolaev V, de Wit C, Leichert L, Feil R, Eaton P, and Cuello F. (2017) Oxidant sensor in the cGMP-binding pocket of PKGIα regulates nitroxyl-mediated kinase activity. Scientific reports 7:9938.

García-Betancur JC, Goñi-Moreno A, Horger T, Schott M, Sharan M, Eikmeier J, Wohlmuth B, Zernecke A, Ohlsen K, Kuttler C, Lopez D. (2017) Cell differentiation defines acute and chronic infection cell types in Staphylococcus aureus. Elife 6.

Gil-Pulido J, Cochain C, Lippert MA, Schneider N, Butt E, Amézaga N, Zernecke A. (2017) Deletion of Batf3-dependent antigen-presenting cells does not affect atherosclerotic lesion formation in mice. PLoS One 12(8):e0181947.

Gil-Pulido J, Zernecke A. (2017) Antigen-presenting dendritic cells in atherosclerosis. Eur J Pharmacol 816:25-31. doi: 10.1016/j.ejphar.2017.08.016.

Kraft P, Schuhmann MK, Garz C, Jandke S, Urlaub D, Mencl S, Zernecke A, Heinze HJ, Carare RO, Kleinschnitz C, Schreiber S. (2017) Hypercholesterolemia induced cerebral small vessel disease. PLoS One 12(8):e0182822.

Rowinska Z, Gorressen S, Merx MW, Koeppel TA, Zernecke A, Liehn EA. Using the Sleeve Technique in a Mouse Model of Aortic Transplantation - An Instructional Video. Vis Exp 128.

Röhrig F, Vorlová S, Hoffmann H, Wartenberg M, Escorcia FE, Keller S, Tenspolde M, Weigand I, Gätzner S, Manova K, Penack O, Scheinberg DA, Rosenwald A, Ergün S, Granot Z, Henke E. (2017) VEGF-ablation therapy reduces drug delivery and therapeutic response in ECM-dense tumors. Oncogene 36(1):1-12. doi: 10.1038/onc.2016.182.

Rowinska Z, Koeppel TA, Sanati M, Schelzig H, Jankowski J, Weber C, Zernecke A, Liehn EA. (2017) Role of the CX3C chemokine receptor CX3CR1 in the pathogenesis of atherosclerosis after aortic transplantation. PLoS One 12(2):e0170644.

Rukoyatkina N, Butt E, Subramanian H, Nikolaev VO, Mindukshev I, Walter U, Gambaryan S, Benz PM. (2017) Protein kinase A activation by the anti-cancer drugs ABT-737 and thymoquinone is caspase-3-dependent and correlates with platelet inhibition and apoptosis. Cell Death Dis 8(6):e2898.

Ta-Shma A, Zhang K, Salimova E, Zernecke A, Sieiro-Mosti D, Stegner D, Furtado M, Shaag A, Perles Z, Nieswandt B, Rein AJ, Rosenthal N, Neiman AM, Elpeleg O. (2017) Congenital valvular defects associated with deleterious mutations in the PLD1 gene. Med Genet 54(4):278-286.

von Ungern-Sternberg SNI, Vogel S, Walker-Allgaier B, Geue S, Maurer A, Wild AM, Münzer P, Chatterjee M, Heinzmann D, Kremmer E, Borst O, Loughran P, Zernecke A, Neal MD, Billiar TR, Gawaz M, Seizer P. (2017) Extracellular Cyclophilin A Augments Platelet-Dependent Thrombosis and Thromboinflammation. Thromb Haemost 117(11):2063-2078. doi: 10.1160/TH17-01-0067.

Vorlova S, Koch M, Manthey HD, Cochain C, Busch M, Chaudhari SM, Stegner D, Yepes M, Lorenz K, Nolte MW, Nieswandt B, Zernecke A. (2017) Coagulation factor XII induces pro-inflammatory cytokine responses in macrophages and promotes atherosclerosis in mice. Thromb Haemost 117(1):176-187.

Zernecke A. (2017) CD98 promotes vascular smooth muscle cell accumulation in atherosclerosis to confer plaque stability will be published in Atherosclerosis 256-130.

Publikationen 2016

Busch A, Busch M, Scholz CJ, Kellersmann R, Otto C, Chernogubova E, Maegdefessel L, Zernecke A, Lorenz U. (2016) Aneurysm miRNA Signature Differs, Depending on Disease Localization and Morphology. Int J Mol Sci 17:1.

Cochain C, Zernecke A. (2016) Protective and pathogenic roles of CD8(+) T cells in atherosclerosis. Basic Res Cardiol 111(6):71.

Endres M, Kneitz S, Orth MF, Perera RK, Zernecke A, Butt E. (2016) Regulation of matrix metalloproteinases (MMPs) expression and secretion in MDA-MB-231 breast cancer cells by LIM and SH3 protein 1 (LASP1). Oncotarget 7(39):64244-64259.

Gambaryan S, Subramanian H, Kehrer L, Mindukshev I, Sudnitsyna J, Reiss C, Rukoyatkina N, Friebe A, Sharina I, Martin E, Walter U. (2016) Erythrocytes do not activate purified and platelet soluble guanylate cyclases even in conditions favourable for NO synthesis. Cell Commun Signal 14(1):16.

Greißel A, Culmes M, Burgkart R, Zimmermann A, Eckstein HH, Zernecke A, Pelisek J. (2016) Histone acetylation and methylation significantly change with severity of atherosclerosis in human carotid plaques. Cardiovasc Pathol 25(2):79-86.

Han Y, Tanios F, Reeps C, Zhang J, Schwamborn K, Eckstein HH, Zernecke A, Pelisek J. (2016) Histone acetylation and histone acetyltransferases show significant alterations in human abdominal aortic aneurysm. Clin Epigenetics 8:3.

Howangyin KY, Zlatanova I, Pinto C, Ngkelo A, Cochain C, Rouanet M, Vilar J, Lemitre M, Stockmann C, Fleischmann BK, Mallat Z, Silvestre JS. (2016) Myeloid-Epithelial-Reproductive Receptor Tyrosine Kinase and Milk Fat Globule Epidermal Growth Factor 8 Coordinately Improve Remodeling After Myocardial Infarction via Local Delivery of Vascular Endothelial Growth Factor. Circulation 133(9):826-39.

Segerer SE, Bartmann C, Kaspar S, Müller N, Kapp M, Butt E, Kämmerer U. (2016) The cytoskeletal protein LASP-1 differentially regulates migratory activities of choriocarcinoma cells. Arch Gynecol Obstet 293(2):407-14.

Simsekyilmaz S, Liehn EA, Weinandy S, Schreiber F, Megens RT, Theelen W, Smeets R, Jockenhövel S, Gries T, Möller M, Klee D, Weber C, Zernecke A. (2016) Targeting In-Stent-Stenosis with RGD- and CXCL1-Coated Mini-Stents in Mice. PLoS ONE 11(5):e0155829.

Subramanian H, Döring F, Kollert S, Rukoyatkina N, Sturm J, Gambaryan S, Stellzig-Eisenhauer A, Meyer-Marcotty P, Eigenthaler M, Wischmeyer E. (2016) PTH1R Mutants Found in Patients with Primary Failure of Tooth Eruption Disrupt G-Protein Signaling. PLoS ONE 11(11):e0167033.

Wildgruber M, Czubba M, Aschenbrenner T, Wendorff H, Hapfelmeier A, Glinzer A, Schiemann M, Zimmermann A, Eckstein HH, Berger H, Wohlgemuth WA, Meier R, Libby P, Zernecke A. (2016) Increased intermediate CD14(++)CD16(++) monocyte subset levels associate with restenosis after peripheral percutaneous transluminal angioplasty. Atherosclerosis 253:128-134.

Zernecke A, Preissner KT. (2016) Extracellular Ribonucleic Acids (RNA) Enter the Stage in Cardiovascular Disease. Circ Res 118(3):469-79.

Publikationen 2015

Böhmer A, Gambaryan S, Tsikas D. (2015) Human blood platelets lack nitric oxide synthase activity. Platelets 26(6):583-8.

Chaudhari SM, Sluimer JC, Koch M, Theelen TL, Manthey HD, Busch M, Caballero-Franco C, Vogel F, Cochain C, Pelisek J, Daemen MJ, Lutz MB, Görlach A, Kissler S, Hermanns HM, Zernecke A. (2015) Deficiency of HIF1? in Antigen-Presenting Cells Aggravates Atherosclerosis and Type 1 T-Helper Cell Responses in Mice. Arterioscler Thromb Vasc Biol 35(11):2316-25.

Cochain C, Koch M, Chaudhari SM, Busch M, Pelisek J, Boon L, Zernecke A. (2015) CD8+ T Cells Regulate Monopoiesis and Circulating Ly6C-high Monocyte Levels in Atherosclerosis in Mice. Circ Res 117(3):244-53.

Cochain C, Zernecke A. (2015) Macrophages and immune cells in atherosclerosis: recent advances and novel concepts. Basic Res Cardiol 110(4):34.

Greißel A, Culmes M, Napieralski R, Wagner E, Gebhard H, Schmitt M, Zimmermann A, Eckstein HH, Zernecke A, Pelisek J. (2015) Alternation of histone and DNA methylation in human atherosclerotic carotid plaques. Thromb Haemost 114(2):390-402.

Kraft P, Schuhmann MK, Fluri F, Lorenz K, Zernecke A, Stoll G, Nieswandt B, Kleinschnitz C. (2015) Efficacy and Safety of Platelet Glycoprotein Receptor Blockade in Aged and Comorbid Mice With Acute Experimental Stroke. Stroke 46(12):3502-6.

Orth MF, Cazes A, Butt E, Grunewald TG. (2015) An update on the LIM and SH3 domain protein 1 (LASP1): a versatile structural, signaling, and biomarker protein. Oncotarget 6(1):26-42.

Reiss C, Mindukshev I, Bischoff V, Subramanian H, Kehrer L, Friebe A, Stasch JP, Gambaryan S, Walter U. (2015) The sGC stimulator riociguat inhibits platelet function in washed platelets but not in whole blood. Br J Pharmacol 172(21):05199-210.

Schütze F, Röhrig F, Vorlová S, Gätzner S, Kuhn A, Ergün S, Henke E. (2015) Inhibition of Lysyl Oxidases Improves Drug Diffusion and Increases Efficacy of Cytotoxic Treatment in 3D Tumor Models. Sci Rep 5:17576.

Sharina IG, Sobolevsky M, Papakyriakou A, Rukoyatkina N, Spyroulias GA, Gambaryan S, Martin E. (2015) The fibrate gemfibrozil is a NO- and haem-independent activator of soluble guanylyl cyclase: in vitro studies. Br J Pharmacol 172(9):2316-29.

Vaman V S A, Poppe H, Houben R, Grunewald TG, Goebeler M, Butt E. (2015) LASP1, a Newly Identified Melanocytic Protein with a Possible Role in Melanin Release, but Not in Melanoma Progression. PLoS ONE 10(6):e0129219.

Weber H, Kittel-Schneider S, Heupel J, Weißflog L, Kent L, Freudenberg F, Alttoa A, Post A, Herterich S, Haavik J, Halmøy A, Fasmer OB, Landaas ET, Johansson S, Cormand B, Ribasés M, Sánchez-Mora C, Ramos-Quiroga JA, Franke B, Lesch KP, Reif A. (2015) On the role of NOS1 ex1f-VNTR in ADHD-allelic, subgroup, and meta-analysis. Am J Med Genet B Neuropsychiatr Genet 168(6):445-458.

Wendorff C, Wendorff H, Pelisek J, Tsantilas P, Zimmermann A, Zernecke A, Kuehnl A, Eckstein HH. (2015) Carotid Plaque Morphology Is Significantly Associated With Sex, Age, and History of Neurological Symptoms. Stroke 46(11):3213-9.

Zernecke A. (2015) Dendritic cells in atherosclerosis: evidence in mice and humans. Arterioscler Thromb Vasc Biol 35(4):763-70.

Publikationen 2014

Beck F, Geiger J, Gambaryan S, Veit J, Vaudel M, Nollau P, Kohlbacher O, Martens L, Walter U, Sickmann A, Zahedi RP. (2014) Time-resolved characterization of cAMP/PKA-dependent signaling reveals that platelet inhibition is a concerted process involving multiple signaling pathways. Blood 123(5):e1-e10.

Böhmer A, Gambaryan S, Flentje M, Jordan J, Tsikas D. (2014) Ureido-¹?N]citrulline UPLC-MS/MS nitric oxide synthase (NOS) activity assay: development, validation, and applications to assess NOS uncoupling and human platelets NOS activity. J Chromatogr B Analyt Technol Biomed Life Sci 965:173-82.

Bot I, Daissormont IT, Zernecke A, van Puijvelde GH, Kramp B, de Jager SC, Sluimer JC, Manca M, Hérias V, Westra MM, Bot M, van Santbrink PJ, van Berkel TJ, Su L, Skjelland M, Gullestad L, Kuiper J, Halvorsen B, Aukrust P, Koenen RR, Weber C, Biessen EA. (2014) CXCR4 blockade induces atherosclerosis by affecting neutrophil function. J Mol Cell Cardiol 74:44-52.

Burkhart JM, Gambaryan S, Watson SP, Jurk K, Walter U, Sickmann A, Heemskerk JW, Zahedi RP. (2014) What can proteomics tell us about platelets? Circ Res 114(7):1204-19.

Busch M, Westhofen TC, Koch M, Lutz MB, Zernecke A. (2014) Dendritic cell subset distributions in the aorta in healthy and atherosclerotic mice. PLoS ONE 9(2):e88452.

Chen W, Thielmann I, Gupta S, Subramanian H, Stegner D, van Kruchten R, Dietrich A, Gambaryan S, Heemskerk JW, Hermanns HM, Nieswandt B, Braun A. (2014) Orai1-induced store-operated Ca(2+) entry enhances phospholipase activity and modulates canonical transient receptor potential channel 6 function in murine platelets. J Thromb Haemost 12(4):528-39.

Cochain C, Chaudhari SM, Koch M, Wiendl H, Eckstein HH, Zernecke A. (2014) Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice. PLoS ONE 9(4):e93280.

Cochain C, Zernecke A. (2014 )Noncoding RNAs in vascular inflammation and atherosclerosis: recent advances toward therapeutic applications. Curr Opin Lipidol 25(5):380-6.

Frietsch JJ, Kastner C, Grunewald TG, Schweigel H, Nollau P, Ziermann J, Clement JH, La Rosée P, Hochhaus A, Butt E. (2014) LASP1 is a novel BCR-ABL substrate and a phosphorylation-dependent binding partner of CRKL in chronic myeloid leukemia. Oncotarget 5(14):5257-71.

Hailer A, Grunewald TG, Orth M, Reiss C, Kneitz B, Spahn M, Butt E. (2014) Loss of tumor suppressor mir-203 mediates overexpression of LIM and SH3 Protein 1 (LASP1) in high-risk prostate cancer thereby increasing cell proliferation and migration. Oncotarget 5(12):4144-4153.

Hubertus K, Mischnik M, Timmer J, Herterich S, Mark R, Moulard M, Walter U, Geiger J. (2014) Reciprocal regulation of human platelet function by endogenous prostanoids and through multiple prostanoid receptors. Eur J Pharmacol 740:15-27.

Koch M, Zernecke A. (2014) The hemostatic system as a regulator of inflammation in atherosclerosis. IUBMB Life 66(11):735-44.

Mischnik M, Gambaryan S, Subramanian H, Geiger J, Schütz C, Timmer J, Dandekar T. (2014) A comparative analysis of the bistability switch for platelet aggregation by logic ODE based dynamical modeling. Mol Biosyst 10(8):2082-9.

Navdaev A, Subramanian H, Petunin A, Clemetson KJ, Gambaryan S, Walter U. (2014) Echicetin coated polystyrene beads: a novel tool to investigate GPIb-specific platelet activation and aggregation. PLoS ONE 9(4):e93569.

Rowinska Z, Gorressen S, Merx MW, Koeppel TA, Liehn EA, Zernecke A. (2014) Establishment of a new murine elastase-induced aneurysm model combined with transplantation. PLoS ONE 9(7):e102648.

Simsekyilmaz S, Cabrera-Fuentes HA, Meiler S, Kostin S, Baumer Y, Liehn EA, Weber C, Boisvert WA, Preissner KT, Zernecke A. (2014) Role of extracellular RNA in atherosclerotic plaque formation in mice. Circulation 129(5):598-606.

Tilstam PV, Gijbels MJ, Habbeddine M, Cudejko C, Asare Y, Theelen W, Zhou B, Döring Y, Drechsler M, Pawig L, Simsekyilmaz S, Koenen RR, de Winther MP, Lawrence T, Bernhagen J, Zernecke A, Weber C, Noels H. (2014) Bone marrow-specific knock-in of a non-activatable Ikk? kinase mutant influences haematopoiesis but not atherosclerosis in Apoe-deficient mice. PLoS ONE 9(2):e87452.

Zernecke A, Weber C. (2014) Chemokines in atherosclerosis: proceedings resumed. Arterioscler Thromb Vasc Biol 34(4):742-50.

Publikationen 2013

Ardelt P, Grünemay N, Strehl A, Jilg C, Miernik A, Kneitz B, Butt E. (2013) LASP-1, a novel urinary marker for detection of bladder cancer. Urol Oncol 31(8):1591-8.

Begonja AJ, Gambaryan S, Schulze H, Patel-Hett S, Italiano JE, Hartwig JH, Walter U. (2013) Differential roles of cAMP and cGMP in megakaryocyte maturation and platelet biogenesis. Exp Hematol 41(1):91-101.e4.

Benz PM, Merkel CJ, Offner K, Abeßer M, Ullrich M, Fischer T, Bayer B, Wagner H, Gambaryan S, Ursitti JA, Adham IM, Linke WA, Feller SM, Fleming I, Renné T, Frantz S, Unger A, Schuh K    2013    Mena/VASP and ?II-Spectrin complexes regulate cytoplasmic actin networks in cardiomyocytes and protect from conduction abnormalities and dilated cardiomyopathy. Cell Commun Signal 11:56.

Boehmer Anke, Niemann Jonas, Schwedhelm KathrinS, Meyer HartmutH, Gambaryan Stepan, Tsikas Dimitrios. (2013) Potential pitfalls with the use of acetoxy (CH3COO) drugs in studies on nitric oxide synthase in platelets. Nitric Oxide 28:14-16.

Grunewald TG, Willier S, Janik D, Unland R, Reiss C, Prazeres da Costa O, Buch T, Dirksen U, Richter GH, Neff F, Burdach S, Butt E. (2013) The Zyxin-related protein thyroid receptor interacting protein 6 (TRIP6) is overexpressed in Ewing's sarcoma and promotes migration, invasion and cell growth. Biol Cell 105(11):535-47.

Hahne JC, Meyer SR, Gambaryan S, Walter U, Dietl J, Engel JB, Honig A. (2013) Immune escape of AKT overexpressing ovarian cancer cells. Int J Oncol 42(5):1630-5.

Lies B, Groneberg D, Gambaryan S, Friebe A. (2013) Lack of effect of ODQ does not exclude cGMP signalling via NO-sensitive guanylyl cyclase. Br J Pharmacol 170(2):317-27.

Mihlan S, Reiß C, Thalheimer P, Herterich S, Gaetzner S, Kremerskothen J, Pavenstädt HJ, Lewandrowski U, Sickmann A, Butt E. (2013) Nuclear import of LASP-1 is regulated by phosphorylation and dynamic protein-protein interactions. Oncogene 32(16):2107-13.

Mischnik M, Boyanova D, Hubertus K, Geiger J, Philippi N, Dittrich M, Wangorsch G, Timmer J, Dandekar T. (2013) A Boolean view separates platelet activatory and inhibitory signalling as verified by phosphorylation monitoring including threshold behaviour and integrin modulation. Mol Biosyst 9(6):1326-39.

Mischnik M, Hubertus K, Geiger J, Dandekar T, Timmer J. (2013) Dynamical modelling of prostaglandin signalling in platelets reveals individual receptor contributions and feedback properties. Mol Biosyst 9(10):2520-9.

Rukoyatkina N, Mindukshev I, Walter U, Gambaryan S. (2013) Dual role of the p38 MAPK/cPLA2 pathway in the regulation of platelet apoptosis induced by ABT-737 and strong platelet agonists. Cell Death Dis 4:e931.

Schweigel H, Geiger J, Beck F, Buhs S, Gerull H, Walter U, Sickmann A, Nollau P. (2013) Deciphering of ADP-induced, phosphotyrosine-dependent signaling networks in human platelets by Src-homology 2 region (SH2)-profiling. Proteomics 13(6):1016-27.

Subramanian H, Zahedi RP, Sickmann A, Walter U, Gambaryan S. (2013) Phosphorylation of CalDAG-GEFI by protein kinase A prevents Rap1b activation. J Thromb Haemost 11(8):1574-82.

von Papen M, Gambaryan S, Schütz C, Geiger J. (2013) Determination of ATP and ADP Secretion from Human and Mouse Platelets by an HPLC Assay. Transfus Med Hemother 40(2):109-16.

Willier S, Butt E, Grunewald TG. (2013) Lysophosphatidic acid (LPA) signalling in cell migration and cancer invasion: a focussed review and analysis of LPA receptor gene expression on the basis of more than 1700 cancer microarrays. Biol Cell 105(8):317-33.

Publikationen 2012

Burkhart JM, Vaudel M, Gambaryan S, Radau S, Walter U, Martens L, Geiger J, Sickmann A, Zahedi RP. (2012) The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathways. Blood 120(15):e73-82.

Gambaryan S, Butt E, Kobsar A, Geiger J, Rukoyatkina N, Parnova R, Nikolaev VO, Walter U. (2012) The oligopeptide DT-2 is a specific PKG I inhibitor only in vitro, not in living cells. Br J Pharmacol 167(4):826-38.

Grunewald TG, Diebold I, Esposito I, Plehm S, Hauer K, Thiel U, da Silva-Buttkus P, Neff F, Unland R, Müller-Tidow C, Zobywalski C, Lohrig K, Lewandrowski U, Sickmann A, Prazeres da Costa O, Görlach A, Cossarizza A, Butt E, Richter GH, Burdach S. (2012) STEAP1 is associated with the invasive and oxidative stress phenotype of Ewing tumors. Mol Cancer Res 10(1):52-65.

Hahne JC, Honig A, Meyer SR, Gambaryan S, Walter U, Wischhusen J, Häussler SF, Segerer SE, Fujita N, Dietl J, Engel JB. (2012) Downregulation of AKT reverses platinum resistance of human ovarian cancers in vitro. Oncol Rep 28(6):2023-8.

Kobsar A, Koessler J, Kehrer L, Gambaryan S, Walter U. (2012) The thrombin inhibitors hirudin and Refludan(®) activate the soluble guanylyl cyclase and the cGMP pathway in washed human platelets. Thromb Haemost 107(3):521-9.

Mindukshev I, Gambaryan S, Kehrer L, Schuetz C, Kobsar A, Rukoyatkina N, Nikolaev VO, Krivchenko A, Watson SP, Walter U, Geiger J. (2012) Low angle light scattering analysis: a novel quantitative method for functional characterization of human and murine platelet receptors. Clin Chem Lab Med 50(7):1253-62.

Nikolaeva S, Bachteeva V, Fock E, Herterich S, Lavrova E, Borodkina A, Gambaryan S, Parnova R. (2012) Frog urinary bladder epithelial cells express TLR4 and respond to bacterial LPS by increase of iNOS expression and L-arginine uptake. Am J Physiol Regul Integr Comp Physiol 303(10):R1042-52.

Stölting M, Wiesner C, van Vliet V, Butt E, Pavenstädt H, Linder S, Kremerskothen J. (2012) Lasp-1 regulates podosome function. PLoS ONE 7(4):e35340.

Sturm JB, Hess M, Weibel S, Chen NG, Yu YA, Zhang Q, Donat U, Reiss C, Gambaryan S, Krohne G, Stritzker J, Szalay AA. (2012) Functional hyper-IL-6 from vaccinia virus-colonized tumors triggers platelet formation and helps to alleviate toxicity of mitomycin C enhanced virus therapy. J Transl Med 10:9.

Subramanian H, Gambaryan S, Panzer S, Gremmel T, Walter U, Mannhalter C. (2012) The Thr715Pro variant impairs terminal glycosylation of P-selectin. Thromb Haemost 108(5):963-72.

Kontakt, Öffnungszeiten, Sprechzeiten

Telefon 

Sekretariat
Silvia Schülein
Tel: +49 931 201-48331

Institutsleitung
Prof. Dr. Alma Zernecke-Madsen
+49 931 201-48330

E-Mail

instexbio2@ ukw.de

Prof. Dr. Alma Zernecke-Madsen
zernecke_a@ ukw.de

Fax

+49 931 201-648341


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Institut für Experimentelle Biomedizin des Universitätsklinikums | Lehrstuhl II | Josef-Schneider-Str. 2 | Haus D16 | 97080 Würzburg | Deutschland