Publikationen Zentrum für das Multiple Myelom

Bachmann F, Schreder M, Engelhardt M, Langer C, Wolleschak D, Mügge LO, Dürk H, Schäfer-Eckart K, Blau IW, Gramatzki M, Liebisch P, Grube M, V Metzler I, Bassermann F, Metzner B, Röllig C, Hertenstein B, Khandanpour C, Dechow T, Hebart H, Jung W, Theurich S, Maschmeyer G, Salwender H, Hess G, Bittrich M, Rasche L, Brioli A, Eckardt KU, Straka C, Held S, Einsele H, Knop S (2021)
Kinetics of Renal Function during Induction in Newly Diagnosed Multiple Myeloma: Results of Two Prospective Studies by the German Myeloma Study Group DSMM.
Cancers (Basel) 2021 Mar 16; 13(6): 1322
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Bazarbachi AH, Labopin M, Kröger N, Brecht A, Blaise D, Clausen J, Fanin R, Einsele H, Cavanna L, Itäla-Remes M, Bulabois CE, Kündgen L, Martin H, Schmid C, Wagner-Drouet EM, Alakel N, Bazarbachi A, Savani B, Nagler A, Mohty M (2021)
Predictive Factors for Outcome of First Allogeneic Transplant for Elderly Patients With Acute Lymphoblastic Leukemia.
Clinical Lymphoma, Myeloma Leukemia 2021 Dec 1; 21(12): 831-840
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Bruno B, Wäsch R, Engelhardt M, Gay F, Giaccone L, D'Agostino M, Rodríguez- Lobato LG, Danhof S, Gagelmann N, Kröger N, Popat R, Van de Donk NWCJ, Terpos E, Dimopoulos MA, Sonneveld P, Einsele H, Boccadoro M (2021)
European Myeloma Network perspective on CAR T-Cell therapies for multiple myeloma.
Haematologica 2021 Aug 1; 106(8): 2054-2065
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Da Vià MC, Dietrich O, Truger M, Arampatzi P, Duell J, Heidemeier A, Zhou X, Danhof S, Kraus S, Chatterjee M, Meggendorfer M, Twardziok S, Goebeler ME, Topp MS, Hudecek M, Prommersberger S, Hege K, Kaiser S, Fuhr V, Weinhold N, Rosenwald A, Erhard F, Haferlach C, Einsele H, Kortüm KM, Saliba AE, Rasche L (2021)
Homozygous BCMA gene deletion in response to anti-BCMA CAR T cells in a patient with multiple myeloma.
Naturmedicine 2021 Apr; 27(4): 616-619
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Danhof S, Rasche L, Mottok A, Steinmüller T, Zhou X, Schreder M, Kilian T, Strifler S, Rosenwald A, Hudecek M, Einsele H, Gerhard-Hartmann E (2021)
Elotuzumab for the treatment of extramedullary myeloma: a retrospective analysis of clinical efficacy and SLAMF7 expression patterns.
Annals of Hematology 2021 Jun; 100(6): 1537-1546
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Dimopoulos MA, Moreau P, Terpos E, Mateos MV, Zweegman S, Cook G, Delforge M, Hájek R, Schjesvold F, Cavo M, Goldschmidt H, Facon T, Einsele H, Boccadoro M, San-Miguel J, Sonneveld P, Mey U, EHA Guidelines Committee, ESMO Guidelines Committee (2021)
Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up.
Annals of Oncology 2021 Mar 1; 32(3): 309-322
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Dimopoulos MA, Moreau P, Terpos E, Mateos MV, Zweegman S, Cook G, Delforge M, Hájek R, Schjesvold F, Cavo M, Goldschmidt H, Facon T, Einsele H, Boccadoro M, San-Miguel J, Sonneveld P, Mey U (2021)
Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up.
Hemasphere 2021 Feb 3; 5(2): e528
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Dimopoulos MA, Terpos E, Boccadoro M, Delimpasi S, Beksac M, Katodritou E, Moreau P, Baldini L, Symeonidis A, Bila J, Oriol A, Mateos MV, Einsele H, Orfanidis I, Ahmadi T, Ukropec J, Kampfenkel T, Schecter JM, Qiu Y, Amin H, Vermeulen J, Carson R, Sonneveld P, APOLLO Trial Investigators (2021)
Daratumumab plus pomalidomide and dexamethasone versus pomalidomide and dexamethasone alone in previously treated multiple myeloma (APOLLO): an open-label, randomised, phase 3 trial.
The Lancet Oncology 2021 Jun; 22(6): 801-812
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Einsele H, Briones J, Ciceri F, García Cadenas I, Falkenburg F, Bolaños N, Heemskerk HMM, Houot R, Hudecek M, Locatelli F, Morgan K, Morris EC, O'Dwyer M, Sierra JG, van den Brink M, van de Loosdrecht AA (2021)
The EHA Research Roadmap: Immune-based Therapies for Hematological Malignancies.
Hemasphere 2021 Sep 10; 5(10): e642
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Fernández de Larrea C, Kyle R, Rosiñol L, Paiva B, Engelhardt M, Usmani S, Caers J, Gonsalves W, Schjesvold F, Merlini G, Lentzch S, Ocio E, Garderet L, Moreau P, Sonneveld P, Badros A, Gahrton G, Goldschmidt H, Tuchman S, Einsele H, Durie B, Wirk B, Musto P, Hayden P, Kaiser M, Miguel JS, Bladé J, Rajkumar SV, Mateos MV (2021)
Primary plasma cell leukemia: consensus definition by the International Myeloma Working Group according to peripheral blood plasma cell percentage.
Blood Cancer Journal 2021 Dec 2; 11(12): 192
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García-Guerrero E, Götz R, Doose S, Sauer M, Rodríguez-Gil A, Nerreter T, Kortüm KM, Pérez-Simón JA, Einsele H, Hudecek M, Danhof S (2021)
Upregulation of CD38 expression on multiple myeloma cells by novel HDAC6 inhibitors is a class effect and augments the efficacy of daratumumab.
Leukemia 2021 Jan; 35(1): 201-214
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Gay F, Günther A, Offidani M, Engelhardt M, Salvini M, Montefusco V, Patriarca F, Aquino S, Pönisch W, Spada S, Schub N, Gentili S, Wäsch R, Corradini P, Straka C, Palumbo A, Einsele H, Boccadoro M, Sonneveld P, Gramatzki M (2021)
Carfilzomib, bendamustine, and dexamethasone in patients with advanced multiple myeloma: The EMN09 phase 1/2 study of the European Myeloma Network.
Cancer 2021 Sep 15; 127(18): 3413-3421
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Geis M, Nowotny B, Bohn MD, Kouhestani D, Einsele H, Bumm T, Stuhler G (2021)
Combinatorial targeting of multiple myeloma by complementing T cell engaging antibody fragments.
Communications Biology 2021 Jan 8; 4(1):44
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Haertle L, Barrio S, Munawar U, Han S, Zhou X, Vogt C, Fernández RA, Bittrich M, Ruiz-Heredia Y, Da Viá M, Zovko J, Garitano-Trojaola A, Bolli N, Ruckdesche A, Stühmer T, Chatterjee M, Kull M, Krönke J, Agirre X, Martin-Subero JI, Raab P, Einsele H, Rasche L, Martinez-Lopez J, Haaf T, Kortüm KM (2021)
Cereblon enhancer methylation and IMiD resistance in multiple myeloma.
Blood. 2021 Nov 4; 138(18): 1721-1726
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Hayden PJ, Eikema DJ, de Wreede LC, Koster L, Kröger N, Einsele H, Minnema M, Dominietto A, Potter M, Passweg J, Bermúdez A, Nguyen-Quoc S, Platzbecker U, Tischer J, Ciceri F, Veelken JH, Ljungman P, Schaap N, Forcade E, Carella AM, Gandemer V, Arcese W, Bloor A, Olivieri A, Vincent L, Beksac M, Schönland S, Yakoub-Agha I (2021)
Second allogeneic transplants for multiple myeloma: a report from the EBMT Chronic Malignancies Working Party.
Bone Marrow Transplantation 2021 May 11; 56(10): 2367-2381
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Heine R, Thielen FW, Koopmanschap M, Kersten MJ, Einsele H, Jaeger U, Sonneveld P, Sierra J, Smand C, Uyl-de Groot CA (2021)
Health Economic Aspects of Chimeric Antigen Receptor T-cell Therapies for Hematological Cancers: Present and Future.
Hemasphere 2021 Jan 28; 5(2): e524
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Hose D, Schreder M, Hefner J, Bittrich M, Danhof S, Strifler S, Krauth MT, Schoder R, Gisslinger B, Einsele H, Gisslinger H, Knop S (2021)
Elotuzumab, pomalidomide, and dexamethasone is a very well tolerated regimen associated with durable remission even in very advanced myeloma: a retrospective study from two academic centers.
Journal of Cancer Research and Clinical Oncology 2021 Jan; 147(1): 205-212
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Leich E, Schreder M, Pischimarov J, Stühmer T, Steinbrunn T, Rudelius M, Brünnert D, Chatterjee M, Langer C, Keppler S, Heredia-Guerrero SC, Einsele H, Knop S, Bargou RC, Rosenwald A (2021)
Novel molecular subgroups within the context of,receptor tyrosine kinase and adhesion signalling in multiple myeloma.
Blood Cancer Journal 2021 Mar 4; 11(3): 51
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Ludwig H, Boccadoro M, Moreau P, San-Miguel J, Cavo M, Pawlyn C, Zweegman S, Facon T, Driessen C, Hajek R, Dimopoulos MA, Gay F, Avet-Loiseau H, Terpos E, Zojer N, Mohty M, Mateos MV, Einsele H, Delforge M, Caers J, Weisel K, Jackson G, Garderet L, Engelhardt M, van de Donk N, Leleu X, Goldschmidt H, Beksac M, Nijhof I, Abildgaard N, Bringhen S, Sonneveld P (2021)
Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network.
Leukemia 2021 Jan; 35(1): 31-44
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Ludwig H, Sonneveld P, Facon T, San-Miguel J, Avet-Loiseau H, Mohty M, Mateos MV, Moreau P, Cavo M, Pawlyn C, Zweegman S, Engelhardt M, Driessen C, Cook G, Dimopoulos MA, Gay F, Einsele H, Delforge M, Caers J, Weisel K, Jackson G, Garderet L, van de Donk N, Leleu X, Goldschmidt H, Beksac M, Nijhof I, Schreder M, Abildgaard N, Hajek R, Zojer N, Kastritis E, Broijl A, Schjesvold F, Boccadoro M, Terpos E (2021)
COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network.
The Lancet Haematology 2021 Dec 28; 8(12): e934-e946
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Moreau P, Kumar SK, San Miguel J, Davies F, Zamagni E, Bahlis N, Ludwig H, Mikhael J, Terpos E, Schjesvold F, Martin T, Yong K, Durie BGM, Facon T, Jurczyszyn A, Sidana S, Raje N, van de Donk N, Lonial S, Cavo M, Kristinsson SY, Lentzsch S, Hajek R, Anderson KC, João C, Einsele H, Sonneveld P, Engelhardt M, Fonseca R, Vangsted A, Weisel K, Baz R, Hungria V, Berdeja JG, Leal da Costa F, Maiolino A, Waage A, Vesole DH, Ocio EM, Quach H, Driessen C, Bladé J, Leleu X, Riva E, Bergsagel PL, Hou J, Chng WJ, Mellqvist UH, Dytfeld D, Harousseau JL, Goldschmidt H, Laubach J, Munshi NC, Gay F, Beksac M, Costa LJ, Kaiser M, Hari P, Boccadoro M, Usmani SZ, Zweegman S, Holstein S, Sezer O, Harrison S, Nahi H, Cook G, Mateos MV, Rajkumar SV, Dimopoulos MA, Richardson PG (2021)
Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group.
The Lancet Oncology 2021 Mar; 22(3): e105-e118
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Munshi NC, Anderson LD Jr, Shah N, Madduri D, Berdeja J, Lonial S, Raje N, Lin Y, Siegel D, Oriol A, Moreau P, Yakoub-Agha I, Delforge M, Cavo M, Einsele H, Goldschmidt H, Weisel K, Rambaldi A, Reece D, Petrocca F, Massaro M, Connarn JN, Kaiser S, Patel P, Huang L, Campbell TB, Hege K, San-Miguel J (2021)
Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma.
The New England Journal of Medicine 2021 Feb 25; 384(8): 705-716
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Musto P, Engelhardt M, Caers J, Bolli N, Kaiser M, Van de Donk N, Terpos E, Broijl A, De Larrea CF, Gay F, Goldschmidt H, Hajek R, Vangsted AJ, Zamagni E, Zweegman S, Cavo M, Dimopoulos M, Einsele H, Ludwig H, Barosi G, Boccadoro M, Mateos MV, Sonneveld P, Miguel JS (2021)
2021 European Myeloma Network review and consensus statement on smoldering multiple myeloma: how to distinguish (and manage) Dr. Jekyll and Mr. Hyde.
Haematologica 2021 Nov 1; 106(11): 2799-2812
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Prommersberger S, Reiser M, Beckmann J, Danhof S, Amberger M, Quade-Lyssy P, Einsele H, Hudecek M, Bonig H, Ivics Z (2021)
CARAMBA: a first-in-human clinical trial with SLAMF7 CAR-T cells prepared by virus-free Sleeping Beauty gene transfer to treat multiple myeloma.
Gene Therapy 2021 Apr 13; 28(9): 560-571
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Rosiñol L, Beksac M, Zamagni E, Van de Donk NWCJ, Anderson KC, Badros A, Caers J, Cavo M, Dimopoulos MA, Dispenzieri A, Einsele H, Engelhardt M, Fernández de Larrea C, Gahrton G, Gay F, Hájek R, Hungria V, Jurczyszyn A,Kröger N, Kyle RA, Leal da Costa F, Leleu X, Lentzsch S, Mateos MV, Merlini G, Mohty M, Moreau P, Rasche L, Reece D, Sezer O, Sonneveld P, Usmani SZ, Vanderkerken K, Vesole DH, Waage A, Zweegman S, Richardson PG, Bladé J (2021)
Expert review on soft-tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations.
British Journal of Haematology 2021 Aug; 194(3): 496-507
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Solimando AG, Da Vià MC, Leone P, Borrelli P, Croci GA, Tabares P, Brandl A, Di Lernia G, Bianchi FP, Tafuri S, Steinbrunn T, Balduini A, Melaccio A, De Summa S, Argentiero A, Rauert-Wunderlich H, Frassanito MA, Ditonno P, Henke E, Klapper W, Ria R, Terragna C, Rasche L, Rosenwald A, Kortüm MK, Cavo M, Ribatti D, Racanelli V, Einsele H, Vacca A, Beilhack A (2021)
Halting the vicious cycle within the multiple myeloma ecosystem: blocking JAM-A on bone marrow endothelial cells restores angiogenic homeostasis and suppresses tumor progression.
Haematologica 2021 Jul 1; 106(7): 1943-1956
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Straka C, Salwender H, Knop S, Vogel M, Müller J, Metzner B, Langer C, Sayer H, Jung W, Dürk HA, Bassermann F, Gramatzki M, Rösler W, Wolf HH, Brugger W, Engelhardt M, Fischer T, Liebisch P, Einsele H (2021)
Full or intensity-reduced high- dose melphalan and single or double autologous stem cell transplant with or without bortezomib consolidation in patients with newly diagnosed multiple myeloma.
European Journal of Haematology 2021 Nov; 107(5): 529-542
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Truger MS, Duell J, Zhou X, Heimeshoff L, Ruckdeschel A, John M, Riedel A, Hüper S, Peter J, Walter W, Haertle L, Meggendorfer M, Topp MS, Rosenwald A, Da Via MC, Bolli N, Weinhold N, Einsele H, Haferlach C, Kortüm KM, Rasche L (2021)
Single- and double-hit events in genes encoding immune targets before and after T cell-engaging antibody therapy in MM.
Blood Advances 2021 Oct 12; 5(19): 3794-3798
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Zhou X, Bai T, Meckel K, Song J, Jin Y, Kortüm KM, Einsele H, Hou X, Rasche L (2021)
COVID-19 infection in patients with multiple myeloma: a German-Chinese experience from Würzburg and Wuhan.
Annales of Hematology 2021 Mar; 100(3): 843-846
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Zhou X, Einsele H, Danhof S (2021)
[CAR T-cell therapy for multiple myeloma].
Der Internist (Berlin) 2021 May 3; 62(6): 605-610
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Barrio S, Munawar U, Zhu YX, Giesen N, Shi CX, Viá MD, Sanchez R, Bruins L, Demler T, Müller N, Haertle L, Garitano A, Steinbrunn T, Danhof S, Cuenca I, Barrio-Garcia C, Braggio E, Rosenwald A, Martinez-Lopez J, Rasche L, Raab MS, Stewart AK, Einsele H, Stühmer T, Kortüm KM (2020)
IKZF1/3 and CRL4(CRBN) E3 ubiquitin ligase mutations and resistance to immunomodulatory drugs in multiple myeloma.
Haematologica 2020 May; 105(5): e237-e241
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Beauvais D, Danhof S, Hayden PJ, Einsele H, Yakoub-Agha I (2020)
Clinical data, limitations and perspectives on chimeric antigen receptor T-cell therapy in multiple myeloma.
Current Opinion in Oncology 2020 Sep; 32(5): 418-426
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Brioli A, Manz K, Pfirrmann M, Hänel M, Schwarzer AC, Prange-Krex G, Fabisch C, Knop S, Illmer T, Krammer-Steiner B, Hochhaus A, von Lilienfeld-Toal M, Mügge LO (2020)
Frailty impairs the feasibility of induction therapy but not of maintenance therapy in elderly myeloma patients: final results of the German Maintenance Study (GERMAIN).
Journal of Cancer Research and Clinical Oncology 2020 Mar; 146(3): 749-759
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Chari A, Samur MK, Martinez-Lopez J, Cook G, Biran N, Yong K, Hungria V, Engelhardt M, Gay F, García Feria A, Oliva S, Oostvogels R, Gozzetti A, Rosenbaum C, Kumar S, Stadtmauer EA, Einsele H, Beksac M, Weisel K, Anderson KC, Mateos MV, Moreau P, San-Miguel J, Munshi NC, Avet-Loiseau H (2020)
Clinical features associated with COVID-19 outcome in multiple myeloma: first results from the International Myeloma Society data set.
Blood 2020 Dec 24; 136(26): 3033-3040
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Cordas Dos Santos D, Erickson N, Gerland L, Jundt F, Theurich S (2020)
Primär- und Sekundärprävention des Multiplen Myeloms – Lebensstilfaktoren und Supportivmaßnahmen.
Deutsche Medizinische Wochenschrift 2020 Jun 17; 145(12): 836-842
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Da Vià MC, Solimando AG, Garitano-Trojaola A, Barrio S, Munawar U, Strifler S, Haertle L, Rhodes N, Teufel E, Vogt C, Lapa C, Beilhack A, Rasche L, Einsele H, Kortüm KM (2020)
CIC Mutation as a Molecular Mechanism of Acquired Resistance to Combined BRAF-MEK Inhibition in Extramedullary Multiple Myeloma with Central Nervous System Involvement.
The Oncologist 2020 Feb; 25(2): 112-118
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Dimopoulos MA, Lonial S, White D, Moreau P, Weisel K, San-Miguel J, Shpilberg O, Grosicki S, Špička I, Walter-Croneck A, Magen H, Mateos MV, Belch A, Reece D, Beksac M, Spencer A, Oakervee H, Orlowski RZ, Taniwaki M, Röllig C, Einsele H, Matsumoto M, Wu KL, Anderson KC, Jou YM, Ganetsky A, Singhal AK, Richardson PG (2020)
Elotuzumab, lenalidomide, and dexamethasone in RRMM: final overall survival results from the phase 3 randomized ELOQUENT-2 study.
Blood Cancer Journal 2020 Sep 4; 10(9): 91
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Einsele H, Borghaei H, Orlowski RZ, Subklewe M, Roboz GJ, Zugmaier G, Kufer P, Iskander K, Kantarjian HM (2020)
The BiTE (bispecific T-cell engager) platform: Development and future potential of a targeted immuno-oncology therapy across tumor types.
Cancer 2020 Jul 15; 126(14): 3192-3201
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Engelhardt M, Shoumariyeh K, Rösner A, Ihorst G, Biavasco F, Meckel K, von Metzler I, Treurich S, Hebart H, Grube M, Kull M, Bassermann F, Schäfer-Eckart K, Hoferer A, Einsele H, Rasche L, Wäsch R (2020)
Clinical characteristics and outcome of multiple myeloma patients with concomitant COVID-19 at Comprehensive Cancer Centers in Germany.
Haematologica 2020 Dec 1; 105(12): 2872-2878
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Gran C, Wang J, Nahi H, Koster L, Gahrton G, Einsele H, Niittyvoupio R, Edinger M, Beelen D, Ciceri F, Bornhäuser M, Finke J, de Wreede LC, Ljungman P, Mielke S, Tischer J, Garderet L, Schönland S, Yakoub-Agha I, Kröger N (2020)
Treosulfan conditioning for allogeneic transplantation in multiple myeloma - improved overall survival in first line haematopoietic stem cell transplantation - a large retrospective study by the Chronic Malignancies Working Party of the EBMT.
British Journal of Haematology 2020 Jun; 189(5): e213-e217
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Heidemeier A, Thurner A, Metz C, Pabst T, Heidemeier H, Rasche L, Kortüm KM, Einsele H, Grimm R, Weiland E, Bley TA (2020)
Whole-Body MRI with an Ultrahigh b-Value of 2000 s/mm(2) Improves the Specificity of Diffusion-Weighted Imaging in Patients with Plasma Cell Dyscrasias.
Academic Radiology 2020 Oct 30: S1076-6332(20)30555-9
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Jansen L, Merz M, Engelhardt M, Weisel K, Scheid C, Straka C, Langer C, Salwender H, Einsele H, Kröger N, Beelen DW, Dreger P, Goldschmidt H, Brenner H (2020)
Autologous stem cell transplantation in multiple myeloma patients: utilization patterns and hospital effects. National Registry for Stem Cell Transplants (DRST).
Leukemia & Lymphoma 2020; 61(10): 2365-2374
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Lejeune M, Köse MC, Duray E, Einsele H, Beguin Y, Caers J (2020)
Bispecific, T-Cell-Recruiting Antibodies in B-Cell Malignancies.
Frontiers in Immunology 2020 May 7; 11:762
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Luber V, Lutz M, Abele-Horn M, Einsele H, Grigoleit GU, Mielke S (2020)
Excretion of Ascaris lumbricoides following reduced-intensity allogeneic hematopoietic stem cell transplantation and consecutive treatment with mebendazole.
Transplant Infectious Disease 2020 Feb 19; 22(1): e13224
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Ludwig H, Pönisch W, Knop S, Egle A, Hinke A, Schreder M, Lechner D, Hajek R, Gunsilius E, Petzer A, Weisel K, Niederwieser D, Einsele H, Willenbacher W, Rumpold H, Pour L, Jelinek T, Krenosz KJ, Meckl A, Nolte S, Melchardt T, Greil R, Zojer N (2020)
Quality of life in patients with relapsed/refractory multiple myeloma during ixazomib-thalidomide-dexamethasone induction and ixazomib maintenance therapy and comparison to the general population.
Leukemia & Lymphoma 2020 Feb; 61(2): 377-386
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Mateos MV, Cavo M, Blade J, Dimopoulos MA, Suzuki K, Jakubowiak A, Knop S, Doyen C, Lucio P, Nagy Z, Pour L, Cook M, Grosicki S, Crepaldi A, Liberati AM, Campbell P, Shelekhova T, Yoon SS, Iosava G, Fujisaki T, Garg M, Krevvata M, Chen Y, Wang J, Kudva A, Ukropec J, Wroblewski S, Qi M, Kobos R, San-Miguel J (2020)
Overall survival with daratumumab, bortezomib, melphalan, and prednisone in newly diagnosed multiple myeloma (ALCYONE): a randomised, open-label, phase 3 trial.
The Lancet 2020 Jan 11; 395(10218): 132-141
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Merz M, Dechow T, Scheytt M, Schmidt C, Hackanson B, Knop S (2020)
The clinical management of lenalidomide-based therapy in patients with newly diagnosed multiple myeloma.
Annals of Hematology 2020 Aug 16; 99(8): 1709-1725
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Raab MS, Engelhardt M, Blank A, Goldschmidt H, Agis H, Blau IW, Einsele H, Ferstl B, Schub N, Röllig C, Weisel K, Winderlich M, Griese J, Härtle S, Weirather J, Jarutat T, Peschel C, Chatterjee M (2020)
MOR202, a novel anti-CD38 monoclonal antibody, in patients with relapsed or refractory multiple myeloma: a first-in-human, multicentre, phase 1-2a trial.
The Lancet Haematology 2020 May; 7(5): e381-e394
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Rasche L, Hudecek M, Einsele H (2020)
What is the future of immunotherapy in multiple myeloma?
Blood 2020 Nov 26; 136(22): 2491-2497
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Rodríguez-Lobato LG, Ganzetti M, Fernández de Larrea C, Hudecek M, Einsele H, Danhof S (2020)
CAR T-Cells in Multiple Myeloma: State of the Art and Future Directions.
Frontiers in Oncology 2020 Jul 28; 10: 1243
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Seibold M, Stühmer T, Kremer N, Mottok A, Scholz CJ, Schlosser A, Leich E, Holzgrabe U, Brünnert D, Barrio S, Kortüm MK, Solimando AG, Chatterjee M, Einsele H, Rosenwald A, Bargou RC, Steinbrunn T (2020)
RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS.
Haematologica 2020 Sep 1; 105(9): 2316-2326
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Steinhardt MJ, Wiercinska E, Pham M, Grigoleit GU, Mazzoni A, Da-Via M, Zhou X, Meckel K, Nickel K, Duell J, Krummenast FC, Kraus S, Hopkinson C, Weissbrich B, Müllges W, Stoll G, Kortüm KM, Einsele H, Bonig H, Rasche L (2020)
Progressive multifocal leukoencephalopathy in a patient post allo-HCT successfully treated with JC virus specific donor lymphocytes.
Journal of Translational Medicine 2020 Apr 21; 18(1): 177
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Steinhardt MJ, Zhou X, Krummenast F, Meckel K, Nickel K, Böckle D, Messerschmidt J, Knorz S, Dierks A, Heidemeier A, Lapa C, Einsele H, Rasche L, Kortüm KM (2020)
Sequential CD38 monoclonal antibody retreatment leads to deep remission in a patient with relapsed/refractory multiple myeloma.
International Journal of Immunpathology and Pharmacology 2020 Jan-Dec; 34: 2058738420980258
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Terpos E, Engelhardt M, Cook G, Gay F, Mateos MV, Ntanasis-Stathopoulos I, van de Donk NWCJ, Avet-Loiseau H, Hajek R, Vangsted AJ, Ludwig H, Zweegman S, Moreau P, Einsele H, Boccadoro M, San Miguel J, Dimopoulos MA, Sonneveld P (2020)
Management of patients with multiple myeloma in the era of COVID-19 pandemic: a consensus paper from the European Myeloma Network (EMN).
Leukemia 2020 Aug; 34(8): 2000-2011
Zur Publikation 

Topp MS, Duell J, Zugmaier G, Attal M, Moreau P, Langer C, Krönke J, Facon T, Salnikov AV, Lesley R, Beutner K, Kalabus J, Rasmussen E, Riemann K, Minella AC, Munzert G, Einsele H (2020)
Anti-B-Cell Maturation Antigen BiTE Molecule AMG 420 Induces Responses in Multiple Myeloma.
Journal of Clinical Oncology 2020 Mar 10; 38(8): 775-783
Zur Publikation

Weißbach S, Heredia-Guerrero SC, Barnsteiner S, Großhans L, Bodem J, Starz H, Langer C, Appenzeller S, Knop S, Steinbrunn T, Rost S, Einsele H, Bargou RC, Rosenwald A, Stühmer T, Leich E (2020)
Exon-4 Mutations in KRAS Affect MEK/ERK and PI3K/AKT Signaling in Human Multiple Myeloma Cell Lines.
Cancers (Basel) 2020 Feb 16; 12(2): 455
Zur Publikation

Weyermann C, Straka C, Einsele H (2020)
[Recurrent Therapy of Multiple Myeloma - Individualized Concepts from The Arsenal of Diverse Options].
Deutsche Medizinische Wochenschrift 2020 Jun; 145(12): 820-827
Zur Publikation 

Zhou X, Dierks A, Kertels O, Kircher M, Schirbel A, Samnick S, Buck AK, Knorz S, Böckle D, Scheller L, Messerschmidt J, Barakat M, Kortüm KM, Rasche L, Einsele H, Lapa C (2020)
18F-FDG, 11C-Methionine, and 68Ga-Pentixafor PET/CT in Patients with Smoldering Multiple Myeloma: Imaging Pattern and Clinical Features.
Cancers (Basel) 2020 Aug 18; 12(8): 2333
Zur Publikation

Zhou X, Dierks A, Kertels O, Samnick S, Kircher M, Buck AK, Haertle L, Knorz S, Böckle D, Scheller L, Messerschmidt J, Barakat M, Truger M, Haferlach C, Einsele H, Rasche L, Kortüm KM, Lapa C (2020)
The Link between Cytogenetics/Genomics and Imaging Patterns of Relapse and Progression in Patients with Relapsed/Refractory Multiple Myeloma: A Pilot Study Utilizing 18F-FDG PET/CT.
Cancers (Basel) 2020 Aug 24; 12(9): 2399
Zur Publikation

Zhou X, Einsele H, Danhof S (2020)
Bispecific Antibodies: A New Era of Treatment for Multiple Myeloma.
Journal of Clinical Medicine 2020 Jul 9; 9(7): 2166
Zur Publikation

Zhou X, Flüchter P, Nickel K, Meckel K, Messerschmidt J, Böckle D, Knorz S, Steinhardt MJ, Krummenast F, Danhof S, Einsele H, Kortüm KM, Rasche L (2020)
Carfilzomib Based Treatment Strategies in the Management of Relapsed/Refractory Multiple Myeloma with Extramedullary Disease.
Cancers (Basel) 2020 Apr 23; 12(4): 1035
Zur Publikation 

Zhou X, Rasche L, Kortüm KM, Danhof S, Hudecek M, Einsele H (2020)
Toxicities of Chimeric Antigen Receptor T Cell Therapy in Multiple Myeloma: An Overview of Experience From Clinical Trials, Pathophysiology, and Management Strategies.
Frontiers in Immunology 2020 Dec 23; 11: 620312
Zur Publikation

Zhou X, Steinhardt MJ, Grathwohl D, Meckel K, Nickel K, Leicht HB, Krummenast F, Einsele H, Rasche L, Kortüm KM (2020)
Multiagent therapy with pomalidomide, bortezomib, doxorubicin, dexamethasone, and daratumumab ("Pom-PAD-Dara") in relapsed/refractory multiple myeloma.
Cancer Medicine 2020 Jul 1; 9(16): 5819-5826
Zur Publikation

Ziouti F, Soares AP, Moreno-Jiménez I, Rack A, Bogen B, Cipitria A, Zaslansky P, Jundt F (2020)
An Early Myeloma Bone Disease Model in Skeletally Mature Mice as a Platform for Biomaterial Characterization of the Extracellular Matrix.
Journal of Oncology 2020 Jun 27; 2020: 3985315
Zur Publikation 

Barrio S, Munawar U, Zhu YX, Giesen N, Shi CX, Da Via M, Sanchez R, Bruins L, Demler T, Muller N, Haertle L, Garitano A, Steinbrunn T, Danhof S, Cuenca I, Barrio- Garcia C, Braggio E, Rosenwald A, Martinez-Lopez J, Rasche L, Raab MS, Stewart AK, Einsele H, Stuhmer T, Kortum KM (2019)
IKZF1/3 and CRL4-CRBN E3 ubiquitin ligase mutations and IMiD resistance in multiple myeloma.
Haematologica 2019 Sep 26; 105(5): e237-e241
Zur Publikation

Barrio S, Stuhmer T, Da-Via M, Barrio-Garcia C, Lehners N, Besse A, Cuenca I, Garitano-Trojaola A, Fink S, Leich E, Chatterjee M, Driessen C, Martinez-Lopez J, Rosenwald A, Beckmann R, Bargou RC, Braggio E, Stewart AK, Raab MS, Einsele H,Kortum KM (2019)
Spectrum and functional validation of PSMB5 mutations in multiple myeloma.
Leukemia 2019 Feb; 33(2): 447-456
Zur Publikation

Bringhen S, Milan A, D'Agostino M, Ferri C, Wasch R, Gay F, Larocca A, Offidani M, Zweegman S, Terpos E, Goldschmidt H, Cavo M, Ludwig H, Driessen C, Auner HW, Caers J, Gramatzki M, Dimopoulos MA, Boccadoro M, Einsele H, Sonneveld P, Engelhardt M (2019)
Prevention, monitoring and treatment of cardiovascular adverse events in myeloma patients receiving carfilzomib A consensus paper by the European Myeloma Network and the Italian Society of Arterial Hypertension.
Journal of Internal Medicine 2019 Jul; 286(1): 63-74
Zur Publikation

Da Via MC, Solimando AG, Garitano-Trojaola A, Barrio S, Munawar U, Strifler S, Haertle L, Rhodes N, Teufel E, Vogt C, Lapa C, Beilhack A, Rasche L, Einsele H, Kortum KM (2019)
CIC Mutation as a Molecular Mechanism of Acquired Resistance to Combined BRAF-MEK Inhibition in Extramedullary Multiple Myeloma with Central Nervous System Involvement.
The Oncologist 2019 Oct 18; 25(2): 112-118
Zur Publikation

Danhof S, Strifler S, Hose D, Kortum M, Bittrich M, Hefner J, Einsele H, Knop S, Schreder M (2019)
Clinical and biological characteristics of myeloma patients influence response to elotuzumab combination therapy.
Journal of Cancer Research and Clinical Oncology 2019 Mar; 145(3): 561-571
Zur Publikation

Einsele H, Rasche L, Topp MS, Martin Kortum K, Duell J (2019)
The use of bispecific antibodies to optimize the outcome of patients with acute leukemia, lymphoma and multiple myeloma after SCT.
Bone Marrow Transplantation 2019 Aug; 54 (Suppl 2): 721-726
Zur Publikation

Greil C, Engelhardt M, Ihorst G, Schoeller K, Bertz H, Marks R, Zeiser R, Duyster J, Einsele H, Finke J, Wasch R (2019)
Allogeneic transplantation of multiple myeloma patients may allow long-term survival in carefully selected patients with acceptable toxicity and preserved quality of life.
Haematologica 2019 Feb; 104(2): 370-379
Zur Publikation

Hillengass J, Usmani S, Rajkumar SV, Durie BGM, Mateos MV, Lonial S, Joao C, Anderson KC, Garcia-Sanz R, Riva E, Du J, van de Donk N, Berdeja JG, Terpos E, Zamagni E, Kyle RA, San Miguel J, Goldschmidt H, Giralt S, Kumar S, Raje N, Ludwig H, Ocio E, Schots R, Einsele H, Schjesvold F, Chen WM, Abildgaard N, Lipe BC, Dytfeld D, Wirk BM, Drake M, Cavo M, Lahuerta JJ, Lentzsch S (2019)
International myeloma working group consensus recommendations on imaging in monoclonal plasma cell disorders.
The Lancet Oncology 2019 Jun; 20(6): e302-e312
Zur Publikation

Kircher S, Stolzenburg A, Kortum KM, Kircher M, Da Via M, Samnick S, Buck AK, Einsele H, Rosenwald A, Lapa C (2019)
Hexokinase-2 Expression in (11)C-Methionine- Positive, (18)F-FDG-Negative Multiple Myeloma.
The Journal of Nuclear Medicine 2019 Mar; 60(3): 348-352
Zur Publikation

Knop S, Engelhardt M, Liebisch P, Meisner C, Holler E, Metzner B, Peest D, Kaufmann M, Bunjes D, Straka C, Fischer T, Sezer O, Hentrich M, Ostermann H, Bassermann F, Hess G, Hertenstein B, Freund M, Kropff M, Schmidt CA, Wolf HH, Jung W, Frickhofen N, Mielke S, Bargou RC, Maschmeyer G, Svaldi M, Langer CH, Gramatzki M, Hebart H, Kanz L, Einsele H (2019)
Deutsche Studiengruppe Multiples M. Allogeneic transplantation in multiple myeloma: long-term follow-up and cytogenetic subgroup analysis.
Leukemia 2019 Nov; 33(11): 2710-2719
Zur Publikation

Kortum KM, Einsele H (2019)
Diagnostic and therapeutic considerations on recurrence of multiple myeloma : A current overview.
Der Internist (Berl) 2019 Jan; 60(1): 34-41
Zur Publikation

Lapa C, Kircher M, Da Via M, Schreder M, Rasche L, Kortum KM, Einsele H, Buck AK, Hanscheid H, Samnick S (2019)
Comparison of 11C-Choline and 11C-Methionine PET/CT in Multiple Myeloma.
Clinical Nuclear Medicine 2019 Aug; 44(8): 620-624
Zur Publikation

Lapa C, Hanscheid H, Kircher M, Schirbel A, Wunderlich G, Werner RA, Samnick S, Kotzerke J, Einsele H, Buck AK, Wester HJ, Grigoleit GU (2019)
Feasibility of CXCR4- Directed Radioligand Therapy in Advanced Diffuse Large B-Cell Lymphoma.
Journal of Nuclear Medicine 2019 Jan; 60(1): 60-64
Zur Publikation

Lapa C, Luckerath K, Kircher S, Hanscheid H, Grigoleit GU, Rosenwald A, Stolzenburg A, Kropf S, Einsele H, Wester HJ, Buck AK, Kortum KM, Schirbel A (2019)
Potential influence of concomitant chemotherapy on CXCR4 expression in receptor directed endoradiotherapy.
British Journal of Haematology 2019 Feb; 184(3): 440-443
Zur Publikation

Leleu X, Martin TG, Einsele H, Lyons RM, Durie BGM, Iskander KS, Ailawadhi S (2019)
Role of Proteasome Inhibitors in Relapsed and/or Refractory Multiple Myeloma.
Clinical Lymphoma, Myeloma & Leukrmia 2019 Jan; 19(1): 9-22
Zur Publikation

Loda S, Krebs J, Danhof S, Schreder M, Solimando AG, Strifler S, Rasche L, Kortum M, Kerscher A, Knop S, Puppe F, Einsele H, Bittrich M (2019)
Exploration of Artificial Intelligence Use with ARIES in Multiple Myeloma Research.
Journal of Clinical Medicine 2019 Jul 9; 8(7): 999
Zur Publikation

Ludwig H, Poenisch W, Knop S, Egle A, Schreder M, Lechner D, Hajek R, Gunsilius E, Krenosz KJ, Petzer A, Weisel K, Niederwieser D, Einsele H, Willenbacher W, Melchardt T, Greil R, Zojer N (2019)
Ixazomib-Thalidomide-Dexamethasone for induction therapy followed by Ixazomib maintenance treatment in patients with relapsed/refractory multiple myeloma.
British Journal of Cancer 2019 Sept 27; 121(9): 751-757
Zur Publikation

Maurer S, Herhaus P, Lippenmeyer R, Hanscheid H, Kircher M, Schirbel A, Maurer HC, Buck AK, Wester HJ, Einsele H, Grigoleit GU, Keller U, Lapa C (2019)
Side Effects of CXC- Chemokine Receptor 4-Directed Endoradiotherapy with Pentixather Before Hematopoietic Stem Cell Transplantation.
Journal of Nuclear Medicine 2019 Oct; 60(10): 1399-1405
Zur Publikation

Moreau P, Sonneveld P, Boccadoro M, Cook G, Mateos MV, Nahi H, Goldschmidt H, Dimopoulos MA, Lucio P, Blade J, Delforge M, Hajek R, Ludwig H, Facon T, Miguel JFS, Einsele H (2019)
Chimeric antigen receptor T-cell therapy for multiple myeloma: a consensus statement from The European Myeloma Network.
Haematologica 2019 Dec; 104(12): 2358-2360
Zur Publikation

Munawar U, Rasche L, Muller N, Vogt C, Da-Via M, Haertle L, Arampatzi P, Dietrich S, Roth M, Garitano-Trojaola A, Steinhardt MJ, Strifler S, Gallardo M, Martinez-Lopez J, Bargou RC, Heckel T, Einsele H, Stuhmer T, Kortum KM, Barrio S (2019)
Hierarchy of mono- and biallelic TP53 alterations in multiple myeloma cell fitness.
Blood 2019 Jul; 134(10): 836-840
Zur Publikation

Nerreter T, Letschert S, Gotz R, Doose S, Danhof S, Einsele H, Sauer M, Hudecek M (2019)
Super-resolution microscopy reveals ultra-low CD19 expression on myeloma cells that triggers elimination by CD19 CAR-T.
Nature Communications 2019 Jul; 10(1): 3137
Zur Publikation

Pasca S, Tomuleasa C, Teodorescu P, Ghiaur G, Dima D, Moisoiu V, Berce C, Stefan C, Ciechanover A, Einsele H (2019)
KRAS/NRAS/BRAF Mutations as Potential Targets in Multiple Myeloma.
Frontiers in  Oncology 2019 Oct 24; 9: 1137
Zur Publikation

Rasche L, Einsele H, Nitschmann S (2019)
Treatment of multiple myeloma with elotuzumab plus pomalidomide and dexamethasone.
Der Internist (Berlin) 2019; 60(6): 658-660
No abstract available
Zur Publikation

Solimando AG, Da Via MC, Cicco S, Leone P, Di Lernia G, Giannico D, Desantis V, Frassanito MA, Morizio A, Delgado Tascon J, Melaccio A, Saltarella I, Ranieri G, Ria R, Rasche L, Kortum KM, Beilhack A, Racanelli V, Vacca A, Einsele H (2019)
High-Risk Multiple Myeloma: Integrated Clinical and Omics Approach Dissects the Neoplastic Clone and the Tumor Microenvironment.
Journal of Clinical Medicine 2019 Jul; 8(7): 997
Zur Publikation

Straka C, Knop S, Vogel M, Muller J, Kropff M, Metzner B, Langer C, Sayer H, Jung W, Durk HA, Salwender H, Wandt H, Bassermann F, Gramatzki M, Rosler W, Wolf HH, Brugger W, Fischer T, Liebisch P, Engelhardt M, Einsele H (2019)
Bortezomib consolidation following autologous transplant in younger and older patients with newly diagnosed multiple myeloma in two phase III trials.
European Journal of Haematology 2019 Jul 19; 103(3): 255-267
Zur Publikation

Walker BA, Mavrommatis K, Wardell CP, Ashby TC, Bauer M, Davies F, Rosenthal A, Wang H, Qu P, Hoering A, Samur M, Towfic F, Ortiz M, Flynt E, Yu Z, Yang Z, Rozelle D, Obenauer J, Trotter M, Auclair D, Keats J, Bolli N, Fulciniti M, Szalat R, Moreau P, Durie B, Stewart AK, Goldschmidt H, Raab MS, Einsele H, Sonneveld P, San Miguel J, Lonial S, Jackson GH, Anderson KC, Avet-Loiseau H, Munshi N, Thakurta A, Morgan
G (2019)
A high-risk, Double-Hit, group of newly diagnosed myeloma identified by genomic analysis.
Leukemia 2019 Jan; 33(1): 159-170
Zur Publikation

Went M, Sud A, Forsti A, Halvarsson BM, Weinhold N, Kimber S, van Duin M, Thorleifsson G, Holroyd A, Johnson DC, Li N, Orlando G, Law PJ, Ali M, Chen B, Mitchell JS, Gudbjartsson DF, Kuiper R, Stephens OW, Bertsch U, Broderick P, Campo C, Bandapalli OR, Einsele H, Gregory WA, Gullberg U, Hillengass J, Hoffmann P, Jackson GH, Jockel KH, Johnsson E, Kristinsson SY, Mellqvist UH, Nahi H, Easton D, Pharoah P, Dunning A, Peto J, Canzian F, Swerdlow A, Eeles RA, Kote-Jarai Z, Muir K, Pashayan N, consortium P, Nickel J, Nothen MM, Rafnar T, Ross FM, da Silva Filho MI, Thomsen H, Turesson I, Vangsted A, Andersen NF, Waage A, Walker BA, Wihlborg AK, Broyl A, Davies FE, Thorsteinsdottir U, Langer C, Hansson M, Goldschmidt H, Kaiser M, Sonneveld P, Stefansson K, Morgan GJ, Hemminki K, Nilsson B, Houlston RS (2019)
Author Correction: Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
Nature Communications 2019 Jan 10; 10(1): 213
Zur Publikation

Zilkowski I, Ziouti F, Schulze A, Hauck S, Schmidt S, Mainz L, Sauer M, Albrecht K, Jundt F, Groll J (2019)
Nanogels Enable Efficient miRNA Delivery and Target Gene Downregulation in Transfection-Resistant Multiple Myeloma Cells.
Biomacromolecules 2019 Feb 11; 20(2): 916-926
Zur Publikation

Ziouti F, Ebert R, Rummler M, Krug M, Muller-Deubert S, Ludemann M, Jakob F, Willie BM, Jundt F (2019)
NOTCH Signaling Is Activated through Mechanical Strain in Human Bone Marrow-Derived Mesenchymal Stromal Cells.
Stem Cells International 2019 Feb 26; 2019:5150634
Zur Publikation