Allergologie und kutane Immunologie
AG Kerstan
Vor dem Hintergrund der hohen Komorbidität von Psoriasis und Hidradenitis suppurativa interessieren wir uns insbesondere für zytokingetriebene proinflammatorische Prozesse, die kutane und systemische Entzündung miteinander verbinden. In unseren Projekten kombinieren wir hochauflösende Analysen, um präklinische Krankheitsmodelle sowie prospektiv rekrutierte Patientenkohorten mit translationalem Anspruch zu charakterisieren.
Publikationen
- Dege, T., Kerstan, A., Goebeler, M., & Schmieder, A. (2026). Clinical pearl: Topical Lactobacillus application to disrupt Pseudomonas aeruginosa biofilms and promote healing in chronic wounds. J Am Acad Dermatol, 94(5), e353–e355. doi.org/10.1016/j.jaad.2025.12.071
- Fleissner, J., Dege, T., Benoit, S., Goebeler, M., & Kerstan, A. (2026). Eosinophilia Reflects Type 2 Immune Activation in Newly Diagnosed Bullous Pemphigoid, With No Evidence of Charcot-Leyden Crystals. Allergy. doi.org/10.1111/all.70443
- Frings, V. G., Glasel, M., Rau, M., Geier, A., Fleissner, J., Presser, D., Goebeler, M., & Kerstan, A. (2026). High Prevalence of Metabolic Dysfunction-Associated Steatotic Liver Disease in Patients with Hidradenitis Suppurativa: A Guide to Easily Assess the Clinical Risk of Comorbid Liver Disease. JID Innov, 6(1), 100419. https://doi.org/10.1016/j.xjidi.2025.100419
- Aintablian, A., Cyran, L., Helal, M., Lehmann, C.H.K., Imdahl, F., Gräfenhan, T., Riedel, A., Dudziak, D., Kerstan, A. & Lutz, M.B. (2026). Low-dose allergen targeting to cDC2 induces long-term protection associated with induction of regulatory-like IL 10+ Foxp3- CD8+ T cells in mice. Front Immunol, 17:1846923. https://doi.org/10.3389/fimmu.2026.1846923
- Azeem, M., Helal, M., Klein-Hessling, S., Serfling, E., Goebeler, M., Muhammad, K., & Kerstan, A. (2025). NFATc1 Fosters Allergic Contact Dermatitis Responses by Enhancing the Induction of IL-17-Producing CD8 Cells. J Invest Dermatol, 145(8), 1995–2006 e1995. doi.org/10.1016/j.jid.2024.11.014
- Gran, F., Azeem, M., Serfling, E., Goebeler, M., Kerstan, A., & Muhammad, K. (2025). NFATc1 Abrogation in B Cells Ameliorates Contact Hypersensitivity Responses. Int J Mol Sci, 26(17). doi.org/10.3390/ijms26178125
- Kerstan, A., Dieter, K., Niebergall-Roth, E., Klingele, S., Junger, M., Hasslacher, C., Daeschlein, G., Stemler, L., Meyer-Pannwitt, U., Schubert, K., Klausmann, G., Raab, T., Goebeler, M., Kraft, K., Esterlechner, J., Schroder, H. M., Sadeghi, S., Ballikaya, S., Gasser, M.,…Kluth, M. A. (2022). Translational development of ABCB5(+) dermal mesenchymal stem cells for therapeutic induction of angiogenesis in non-healing diabetic foot ulcers. Stem Cell Res Ther, 13(1), 455. doi.org/10.1186/s13287-022-03156-9
- Cyran, L., Serfling, J., Kirschner, L., Raifer, H., Lohoff, M., Hermanns, H. M., Kerstan, A., Bodem, J., & Lutz, M. B. (2022). Flt3L, LIF, and IL-10 combination promotes the selective in vitro development of ESAM(low) cDC2B from murine bone marrow. Eur J Immunol, 52(12), 1946–1960. doi.org/10.1002/eji.202149663
- Frings, V. G., Roth, N., Glasel, M., Bauer, B., Goebeler, M., Presser, D., & Kerstan, A. (2022). Hidradenitis Suppurativa: Absence of Hyperhidrosis but Presence of a Proinflammatory Signature in Patients' Sweat. Acta Derm Venereol, 102, adv00793. doi.org/10.2340/actadv.v102.2731
- Kerstan, A., Dieter, K., Niebergall-Roth, E., Dachtler, A. K., Kraft, K., Stucker, M., Daeschlein, G., Junger, M., Gorge, T., Meyer-Pannwitt, U., Erfurt-Berge, C., von Engelhardt, C., Klare, A., Pfeiffer, C., Esterlechner, J., Schroder, H. M., Gasser, M., Waaga-Gasser, A. M., Goebeler, M.,…Kluth, M. A. (2022). Allogeneic ABCB5(+) mesenchymal stem cells for treatment-refractory chronic venous ulcers: a phase I/IIa clinical trial. JID Innov, 2(1). doi.org/10.1016/j.xjidi.2021.100067
- Frings, V. G., Bauer, B., Schuster, R., Goebeler, M., Presser, D., & Kerstan, A. (2021). Differences in anatomical area-specific wound healing in hidradenitis suppurativa/acne inversa after surgery. Eur J Dermatol, 31(5), 623–629. doi.org/10.1684/ejd.2021.4148 (Original work published Differences in anatomical area-specific wound healing in hidradenitis suppurativa/acne inversa after surgery.)
- Heitmann, J., Frings, V. G., Geier, A., Goebeler, M., & Kerstan, A. (2021). Non-alcoholic fatty liver disease and psoriasis - is there a shared proinflammatory network? J Dtsch Dermatol Ges, 19(4), 517–528. doi.org/10.1111/ddg.14425
- Kerstan, A., Niebergall-Roth, E., Esterlechner, J., Schroder, H. M., Gasser, M., Waaga-Gasser, A. M., Goebeler, M., Rak, K., Schrufer, P., Endres, S., Hagenbusch, P., Kraft, K., Dieter, K., Ballikaya, S., Stemler, N., Sadeghi, S., Tappenbeck, N., Murphy, G. F., Orgill, D. P.,…Kluth, M. A. (2021). Ex vivo-expanded highly pure ABCB5(+) mesenchymal stromal cells as Good Manufacturing Practice-compliant autologous advanced therapy medicinal product for clinical use: process validation and first in-human data. Cytotherapy, 23(2), 165–175. doi.org/10.1016/j.jcyt.2020.08.012
- Muhammad, K., Xavier, D., Klein-Hessling, S., Azeem, M., Rauschenberger, T., Murti, K., Avots, A., Goebeler, M., Klein, M., Bopp, T., Sielaff, M., Tenzer, S., Mockel, S., Aramburu, J., Lopez-Rodriguez, C., Kerstan, A., & Serfling, E. (2021). NFAT5 Controls the Integrity of Epidermis. Front Immunol, 12, 780727. doi.org/10.3389/fimmu.2021.780727
- Kahlert, K., Gran, F., Muhammad, K., Benoit, S., Serfling, E., Goebeler, M., & Kerstan, A. (2019). Aberrant B-cell Subsets and Immunoglobulin Levels in Patients with Moderate-to-severe Psoriasis. Acta Derm Venereol, 99(2), 226–227. doi.org/10.2340/00015555-3069
- Rauschenberger, T., Schmitt, V., Azeem, M., Klein-Hessling, S., Murti, K., Gran, F., Goebeler, M., Kerstan, A., Klein, M., Bopp, T., Serfling, E., & Muhammad, K. (2019). T Cells Control Chemokine Secretion by Keratinocytes. Front Immunol, 10, 1917. doi.org/10.3389/fimmu.2019.01917
- Stoevesandt, J., Hosp, C., Kerstan, A., & Trautmann, A. (2018). Sensitization to Hymenoptera venom marker allergens: Prevalence, predisposing factors, and clinical implications. Clin Exp Allergy, 48(12), 1735–1743. doi.org/10.1111/cea.13237
- Stoevesandt, J., Hosp, C., Kerstan, A., & Trautmann, A. (2017). Safety of 100 microg venom immunotherapy rush protocols in children compared to adults. Allergy Asthma Clin Immunol, 13, 32. doi.org/10.1186/s13223-017-0204-y
- Alrefai, H., Muhammad, K., Rudolf, R., Pham, D. A., Klein-Hessling, S., Patra, A. K., Avots, A., Bukur, V., Sahin, U., Tenzer, S., Goebeler, M., Kerstan, A., & Serfling, E. (2016). NFATc1 supports imiquimod-induced skin inflammation by suppressing IL-10 synthesis in B cells. Nat Commun, 7, 11724. doi.org/10.1038/ncomms11724
- Stoevesandt, J., Hosp, C., Kerstan, A., & Trautmann, A. (2015). Hymenoptera venom immunotherapy while maintaining cardiovascular medication: safe and effective. Ann Allergy Asthma Immunol, 114(5), 411–416. doi.org/10.1016/j.anai.2015.03.001
- Stoevesandt, J., Hain, J., Stolze, I., Kerstan, A., & Trautmann, A. (2014). Angiotensin-converting enzyme inhibitors do not impair the safety of Hymenoptera venom immunotherapy build-up phase. Clin Exp Allergy, 44(5), 747–755. doi.org/10.1111/cea.12276
- Stoevesandt, J., Hosp, C., Kerstan, A., & Trautmann, A. (2014). Risk stratification of systemic allergic reactions during Hymenoptera venom immunotherapy buildup phase. J Dtsch Dermatol Ges, 12(3), 244–255, 244–256. doi.org/10.1111/ddg.12261
- Kerstan, A., Beyersdorf, N., Stoevesandt, J., & Trautmann, A. (2012). Wasp venom immunotherapy expands a subpopulation of CD4(+)CD25+ forkhead box protein 3-positive regulatory T cells expressing the T-cell receptor Vbeta2 and Vbeta5.1 chains. J Allergy Clin Immunol, 130(4), 994–996 e993. doi.org/10.1016/j.jaci.2012.05.010
- Kerstan, A., Albert, C., Klein, D., Brocker, E. B., & Trautmann, A. (2011). Wasp venom immunotherapy induces activation and homing of CD4(+)CD25(+) forkhead box protein 3-positive regulatory T cells controlling T(H)1 responses. J Allergy Clin Immunol, 127(2), 495–501 e491–496. doi.org/10.1016/j.jaci.2010.11.025
Kontakt, Öffnungszeiten, Sprechzeiten
Terminvereinbarung Poliklinik
Tel. +49 931 201-26714
Montag bis Donnerstag
12:00 Uhr bis 16:00 Uhr
Freitag
12:00 Uhr bis 15:00 Uhr
Terminvereinbarung Privatambulanz
Montag bis Freitag
08:00 Uhr bis 11:00 Uhr
Margit Körner
Tel. +49 931 201-26354
Claudia Keller
Tel. +49 931 201-26354
E-Mail: privatambulanz-derma@ukw.de
Telefon
Pforte
+49 931 201-26710
Direktor
Prof. Dr. med. Matthias Goebeler
Sekretariat
Gudrun Braun
+49 931 201-26351
Studierendenangelegenheiten
Ute Düchs
+49 931 201-26353
Anschrift
Klinik und Poliklinik für Dermatologie, Venerologie und Allergologie | Josef-Schneider-Straße 2 | Haus D8 | 97080 Würzburg | Deutschland
