Publikationen 2020

Adam EH, Funke M, ZacAdam EH, Funke M, Zacharowski K, Meybohm P, Keller H, Weber CF. Adam EH. (2020) Impact of intraoperative cell salvage on blood coagulation factor concentrations in patients undergoing cardiac surgery. Anesth Analg. 2020 May;130(5):1389-1395.

Apfelbacher C, Brandstetter S, Blecha S, Dodoo-Schittko F, Brandl M, Karagiannidis C, Quintel M, Kluge S, Putensen C, Bercker S, Ellger B, Kirschning T, Arndt C, Meybohm P, Weber-Carstens S; DACAPO study group, Bein T, Apfelbacher C. (2020) Influence of quality of intensive care on quality of life/return to work in survivors of the acute respiratory distress syndrome: prospective observational patient cohort study (DACAPO). BMC Public Health. 2020 Jun 5;20(1):861.

Bein T, Weber-Carstens S, Apfelbacher C, Brandstetter S, Blecha S, Dodoo-Schittko F, Brandl M, Quintel M, Kluge S, Putensen C, Bercker S, Ellger B, Kirschning T, Arndt C, Meybohm P, Zeman F, Karagiannidis C, Bein T. (2020) The quality of acute intensive care and the incidence of critical events have an impact on health-related quality of life in survivors of the acute respiratory distress syndrome - a nationwide prospective multicenter observational study. Ger Med Sci. 2020 Jan 20;18:Doc01.

Blecha S, Brandl M, Zeman F, Dodoo-Schittko F, Brandstetter S, Karagiannidis C, Bein T, Apfelbacher C, DACAPO Study Group. Blecha S, Meybohm, P. (2020) Tracheostomy in patients with acute respiratory distress syndrome is not related to quality of life, symptoms of psychiatric disorders or return-to-work: the prospective DACAPO cohort study. Ann Intensive Care. 2020 May 6; 10(1):52.

Blet A, de Roquetaillade C, Hartmann O, Struck J, Mebazaa A, Chousterman BG; Adrenoss-1 study investigators. Blet A, Meybohm P. (2020) Added value of serial bio-adrenomedullin measurement in addition to lactate for the prognosis of septic patients admitted to ICU. Crit Care. 2020 Feb 28;24(1):69.

Curtaz CJ, Schmitt C, Herbert SL, Feldheim J, Schlegel N, Gosselet F, Hagemann C, Roewer N, Meybohm P, Wöckel A, Burek M.Curtaz CJ, et al. (2020) Serum-derived factors of breast cancer patients with brain metastases alter permeability of a human blood-brain barrier model.  Fluids Barriers CNS. 2020 Apr 22;17(1):31.

Drabisnki T, Zacharowski K, Meybohm P, Rüger A, Ramirez de Arellano. (2020) Estimating the epidemiological and economic impact of implementing preoperative anaemia measures in the German healthcare system: the health economic footprint of patient blood management. Adv. Ther. 2020; 37(8): 3515 – 3536. Published online 2020 Jun 19.

Drabinski T, Zacharowski K, Meybohm P, Rüger AM, Ramirez de Arellano A. (2020) Drabinski T, Estimating the epidemiological and economic impact of implementing preoperative anaemia measures in the German healthcare system: the health economic footprint of patient blood management. Adv Ther. 2020 Jun 19.

Gräsner J-T, Bohn A, Seewald S, Bein B, Fischer M, Wnent J, Meybohm P. (2020) COVID-19 und Herz-Kreislauf-Stillst. Aktuelle Anpassung der Guidelines 2015. Anästh Intensivmed 2020; 61:5148-5153.

Herrmann J, Notz Q, Schlesinger T, Schmid B, Stumpner J, Kredel M, Meybohm P. (2020) Analgosedierung bei Covid-19-Intensivpatienten. Besondere Aspekte während der Pandemie. Anästh Intensivmed 2020;61:5154-5158.

Hill A., Heyland D, Elke G, Schaller S, Stocker R, Haberthür C, Von Löffelholz C, Suchner U, Puthucheary Z, Bear D, Ney J, Clasen K, Meybohm P, Lindau S, Laurentius T, Stoppe C. (2020) Meeting nutritional targets of cirtically ill patients by combinded enteral and parenteral nutrition: review and rationale for the EFFORTcombo trial. Nutrition Research Reviews 2020; 1-9.  

Ibarz M, Boumendil A, Haas LEM, Irazabal M, Flaatten H, de Lange DW, Morandi A, Andersen FH, Bertolini G, Cecconi M, Christensen S, Faraldi L, Fjølner J, Jung C, Marsh B, Moreno R, Oeyen S, Öhman CA, Bollen Pinto B, Soliman IW, Szczeklik W, Valentin A, Watson X, Zaferidis T, Guidet B, Artigas A. (2020) VIP1 study. Ibarz M, Meybohm, P, Sepsis at ICU admission does not decrease 30-day survival in very old patients: a post-hoc analysis of the VIP1 multinational cohort study. Ann Intensive Care. 2020 May 13;10(1):56.

Jung-König M, Füllenbach C, Murphy MF, Manzini P, Laspina S, Pendry K, Mühling J, Wikman A, Humbrecht C, Rigal JC, Lasocki S, Folléa G, Seifried E, Müller MM, Geisen C, Aranko K, Zacharowski K, Meybohm P. (2020) the PaBloE (Patient Blood Management in Europe) working group. Programmes for the management of preoperative anaemia: audit in ten European hospitals within the PaBloE (Patient Blood Management in Europe) Working Group. Vox Sang. 2020 Apr;115(3):182-191. (IF 2.364)

Kranke P, Weibel S, Sitter M, Meybohm P, Girard T, Kranke P. (2020) [Obstetric Anesthesia During the SARS-CoV-2 Pandemic - a Brief Overview of Published Recommendations for Action by National and International Specialist Societies and Committees]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2020 Apr;55(4):266-274.

Krone M, Kranke P, Wicker S, Meybohm P, Wöckel A, Vogel U. (2020) Wissenschaftliche Evidenz zur Beschäftigung von Schwangeren in der Patientenversorgung in Zeiten von SARS-CoV-2. Anästh Intensivmed 2020; 61:5159-5163.

Lindhoff-Last E, Herrmann E, Lindau S, Konstantinides S, Grottke O, Nowak-Goettl U, Lucks J, Zydek B, Heymann CV, Birschmann I, Sümnig A, Beyer-Westendorf J, Schellong S, Meybohm P, Greinacher A.Lindhoff-Last E. (2020) Severe hemorrhage associated with oral anticoagulants. Dtsch Arztebl Int. 2020 May 1;117(18):312-319.

Lotz C, Notz Q, Kranke P, Kredel M, Meybohm P, Lotz C. (2020) Unconventional approaches to mechanical ventilation-step-by-step through the COVID-19 crisis. Version 2. Crit Care. 2020 May 18;24(1):233.

Madotto F, Rezoagli E, Pham T, Schmidt M, McNicholas B, Protti A, Panwar R, Bellani G, Fan E, van Haren F, Brochard L, Laffey JG. (2020) LUNG SAFE Investigators and the ESICM Trials Group. Madotto F, Meybohm, P, Hyperoxemia and excess oxygen use in early acute respiratory distress syndrome: insights from the LUNG SAFE study. Crit Care. 2020 Mar 31;24(1):125.

Notz Q, Lotz C, Herrmann, j, Vogt M, Schlesinger T, Kredel M, Muellges W, Weismann D, Westermaier T, Meybohm P, Kranke P. (2020) Severe neurological complications in critically ill COVID-19 patients. J Neurol. 2020 Aug 14: 1-4.

Piekarski F, Kaufmann J, Engelhardt T, Raimann FJ, Lustenberger T, Marzi I, Lefering R, Zacharowski K, Meybohm P. (2020) TraumaRegister DGU.Piekarski F, Changes in transfusion and fluid therapy practices in severely injured children: an analysis of 5118 children from the TraumaRegister DGU®.  Eur J Trauma Emerg Surg. 2020 Jun 29.

Preckel B, Staender S, Arnal D, Brattebø G, Feldman JM, Ffrench-O'Carroll R, Fuchs-Buder T, Goldhaber-Fiebert SN, Haller G, Haugen AS, Hendrickx JFA, Kalkman CJ, Meybohm P, Neuhaus C, Østergaard D, Plunkett A, Schüler HU, Smith AF, Struys MMRF, Subbe CP, Wacker J, Welch J, Whitaker DK, Zacharowski K, Mellin-Olsen J., Preckel B. (2020) Ten years of the Helsinki Declaration on patient safety in anaesthesiology: an expert opinion on peri-operative safety aspects. Eur J Anaesthesiol. 2020 Jul;37(7):521-610.

Schlesinger T, Kranke P, Zacharowski K, Meybohm P, Schlesinger T. (2020) Coronavirus threatens blood supply: patient blood management now! Ann Surg. 2020 May 20:10.1097/SLA.0000000000004086.

Schlesinger T, Choorapoikayil S, Füllenbach, C, Zacharowski K, Meybohm P. (2020) Eigenblut statt Fremdblut. Trillium Diagnostik 2020; 18(2):138–140.

Seppelt PC, Mas-Peiro S, De Rosa R, Murray IM, Arsalan M, Holzer L, Lotz G, Meybohm P, Zacharowski K, Walther T, Zeiher AM, Fichtlscherer S, Vasa-Nicotera M.Seppelt PC. (2020) Dynamics of cerebral oxygenation during rapid ventricular pacing and its impact on outcome in transfemoral transcatheter aortic valve implantation. Catheter Cardiovasc Interv. 2020 May 20.

Wunderer F, Trager L, Sigurslid HH, Meybohm P, Bloch DB, Malhotra R. (2020) The role of hepcidin and iron homeostasis in atherosclerosis. Pharmacol Res. 2020 Mar; 153:104664; Jan 25:104664. (IF 5.574).

Publikationen 2019

Constantinescu C, Bodolea C, Pasca S, Teodorescu P, Dima D, Rus I, Tat T, Achimas-Cadariu P, Tanase A, Tomuleasa C, Einsele H. (2019) Clinical Approach to the Patient in Critical State Following Immunotherapy and/or Stem Cell Transplantation: Guideline for the On-Call Physician. J Clin Med. 2019 Jun 20;8(6):884. doi: 10.3390/jcm8060884. PMID: 31226876 Free PMC article. Review.

Hinkelbein J, Iovino I, De Robertis E, Kranke P. (2019) Outcomes in video laryngoscopy studies from 2007 to 2017: systematic review and analysis of primary and secondary endpoints for a core set of outcomes in video laryngoscopy research. BMC Anesthesiol. 2019 Apr 4;19(1):47. doi: 10.1186/s12871-019-0716-8. PMID: 30947694 Free PMC article.

Kollert S, Döring F, Gergs U, Wischmeyer E. (2019) Naunyn Schmiedebergs Arch Pharmacol. 2020 Apr;393(4):573-580. doi: 10.1007/s00210-019-01751-x. Epub 2019 Nov 13. PMID: 31720798
Chloroform has been used over decades in anesthesia before it was replaced by other volatile anesthetics like halothane or sevoflurane. Chloroform is a potent activator of cardiac and neuronal Kir3 channels.

Lyons G, Kranke P. (2019) Uterine tilt for caesarean section. Eur J Anaesthesiol. 2019 Jan;36(1):6-7. doi: 10.1097/EJA.0000000000000857. PMID: 30520785 No abstract available.

Meybohm P, Lindau S, Treskatsch S, Francis R, Spies C, Velten M, Wittmann M, Gueresir E, Stoppe C, Kowark A, Coburn M, Selleng S, Baschin M, Jenichen G, Meersch M, Ermert T, Zarbock A, Kranke P, Kredel M, Helf A, Laufenberg-Feldmann R, Ferner M, Wittenmeier E, Gürtler KH, Kienbaum P, de Abreu MG, Sander M, Bauer M, Seyfried T, Gruenewald M, Choorapoikayil S, Mueller MM, Seifried E, Brosteanu O, Bogatsch H, Hasenclever D, Zacharowski K. (2019) Liberal transfusion strategy to prevent mortality and anaemia-associated, ischaemic events in elderly non-cardiac surgical patients - the study design of the LIBERAL-Trial. LIBERAL Collaboration Group. Trials. 2019 Feb 4;20(1):101. doi: 10.1186/s13063-019-3200-3. PMID: 30717805 Free PMC article. Clinical Trial.

Polderman JAW, Farhang-Razi V, van Dieren S, Kranke P, DeVries JH, Hollmann MW, Preckel B, Hermanides J. (2019) Adverse side-effects of dexamethasone in surgical patients - an abridged Cochrane systematic review. Anaesthesia. 2019 Jul;74(7):929-939. doi: 10.1111/anae.14610. Epub 2019 Mar 1. PMID: 30821852 Free article.

Schlosser PD, Grundgeiger T, Sanderson PM, Happel O. (2019) An exploratory clinical evaluation of a head-worn display based multiple-patient monitoring application: impact on supervising anesthesiologists' situation awareness. J Clin Monit Comput. 2019 Dec;33(6):1119-1127. doi: 10.1007/s10877-019-00265-4. Epub 2019 Feb 5. PMID: 30721389

Publikationen 2018

Amrein K, Martucci G, Hahner S. (2018) Understanding adrenal crisis. Intensive Care Med. 2018 May;44(5):652-655. doi: 10.1007/s00134-017-4954-2. Epub 2017 Oct 26. PMID: 29075801 Free PMC article. No abstract available.

Bankoglu EE, Broscheit J, Arnaudov T, Roewer N, Stopper H. (2018) Protective effects of tricetinidin against oxidative stress inducers in rat kidney cells: A comparison with delphinidin and standard antioxidants. Food Chem Toxicol. 2018 Nov;121:549-557. doi: 10.1016/j.fct.2018.09.058. Epub 2018 Sep 25. PMID: 30266311

Johannsen S, Türkmeneli I, Isbary S, Roewer N, Schuster F. (2018) Ultrasound Elastography for Rapid, Real-time Detection of Localized Muscular Reaction in Malignant Hyperthermia-susceptible Pigs. Anesthesiology. 2018 Nov;129(5):989-999. doi: 10.1097/ALN.0000000000002424. PMID: 30204593

Kippnich M, Schorscher N, Kredel M, Markus C, Eden L, Gassenmaier T, Lock J, Wurmb T. (2018) Dual-room twin-CT scanner in multiple trauma care: first results after implementation in a level one trauma centre. Eur J Trauma Emerg Surg. 2020 Apr 25:1-6. doi: 10.1007/s00068-020-01374-5. Online ahead of print. PMID: 32335685 Free PMC article.
PURPOSE: The trauma centre of the Wuerzburg University Hospital has integrated a pioneering dual-room twin-CT scanner in a multiple trauma pathway. ...METHODS: All patients with suspected multiple trauma, who required emergency surgery and who were initially diagnos …

Kranke P, Weibel S. (2018) Pain relief during labour: challenging the use of intramuscular pethidine. Lancet. 2018 Aug 25;392(10148):617-619. doi: 10.1016/S0140-6736(18)31717-3. Epub 2018 Aug 13. PMID: 30115485 No abstract available.

Meybohm P, Kohlhaas M, Stoppe C, Gruenewald M, Renner J, Bein B, Albrecht M, Cremer J, Coburn M, Schaelte G, Boening A, Niemann B, Sander M, Roesner J, Kletzin F, Mutlak H, Westphal S, Laufenberg-Feldmann R, Ferner M, Brandes IF, Bauer M, Stehr SN, Kortgen A, Wittmann M, Baumgarten G, Meyer-Treschan T, Kienbaum P, Heringlake M, Schoen J, Treskatsch S, Smul T, Wolwender E, Schilling T, Fuernau G, Bogatsch H, Brosteanu O, Hasenclever D, Zacharowski K. (2018) RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study Collaborators. J Am Heart Assoc. 2018 Mar 26;7(7):e008077. doi: 10.1161/JAHA.117.008077. PMID: 29581218 Free PMC article. Clinical Trial.
RIPHeart (Remote Ischemic Preconditioning for Heart Surgery) Study: Myocardial Dysfunction, Postoperative Neurocognitive Dysfunction, and 1 Year Follow-Up.
CONCLUSIONS: Similar to our main study, RIPC had no effect on intraoperative myocardial dysfunction, neurocognitive function and long-term outcome in cardiac surgery patients undergoing propofol anesthesia. ...

Oerter S, Förster C, Bohnert M. (2018) Validation of sodium/glucose cotransporter proteins in human brain as a potential marker for temporal narrowing of the trauma Formation. Int J Legal Med. 2019 Jul;133(4):1107-1114. doi: 10.1007/s00414-018-1893-6. Epub 2018 Aug 2. PMID: 30073510

Petersilka GJ, Arweiler NB, Otto J, Wittig T. (2018) Non-interventional study to collect data for the application of lidocaine gel 2% during scaling and root planing and professional mechanical plaque removal. Clin Oral Investig. 2019 Feb;23(2):551-558. doi: 10.1007/s00784-018-2468-0. Epub 2018 May 1. PMID: 29717361 Clinical Trial.
Rating of the anesthetic effect of LG by treating personnel and patients using a four-item verbal rating scale (VRS), tolerability, safety (adverse effects), and need for additional local injection anesthesia (ALI). ...

Salvador E, Burek M, Förster CY. (2018) An In Vitro Model of Traumatic Brain Injury. Methods Mol Biol. 2018;1717:219-227. doi: 10.1007/978-1-4939-7526-6_17. PMID: 29468595 Review.

Schuster F, Johannsen S, Isbary S, Türkmeneli I, Roewer N. (2018) In vitro effects of levosimendan on muscle of malignant hyperthermia susceptible and non-susceptible swine. BMC Anesthesiol. 2018 Dec 3;18(1):182. doi: 10.1186/s12871-018-0644-z. PMID: 30509180 Free PMC article.
METHODS: Muscle bundles of 17 pigs (9 MH susceptible (MHS); 8 MH non-susceptible (MHN)) were excised under general anesthesia and examined in the tissue bath with increasing concentrations of levosimendan (0.065; 0.125; 0.5; 1.0; 10 and 50 μg/ml). ...Statistical evaluation

Wurmb T, Schorscher N, Justice P, Dietz S, Schua R, Jarausch T, Kinstle U, Greiner J, Möldner G, Müller J, Kraus M, Simon S, Wagenhäuser U, Hemm J, Roewer N, Helm M. (2018) Structured analysis, evaluation and report of the emergency response to a terrorist attack in Wuerzburg, Germany using a new template of standardised quality indicators. Scand J Trauma Resusc Emerg Med. 2018 Oct 19;26(1):87. doi: 10.1186/s13049-018-0555-5. PMID: 30340516 Free PMC article.
Aim of the presented work was to report the systematic evaluation and the lessons learned from the response to a terror attack that happened in Wuerzburg, Germany in 2016. ...

Publikationen 2017

Amrein K, Martucci G, Hahner S. (2017) Understanding adrenal crisis. Intensive Care Med. 2018 May;44(5):652-655. doi: 10.1007/s00134-017-4954-2. Epub 2017 Oct 26. PMID: 29075801 Free PMC article. No abstract available.

Grau SJ, Löhr M, Taurisano V, Trautner H, Timmer M, Schwab SG, Hampl J, Annecke T. (2017) The choice of anaesthesia for glioblastoma surgery does not impact the time to recurrence. Sci Rep. 2020 Mar 27;10(1):5556. doi: 10.1038/s41598-020-62087-8. PMID: 32221316 Free PMC article.
The aim of this study was to evaluate a potential influence of the anaesthetic method (inhaled anaesthetics versus total-intravenous anaesthesia using propofol) on recurrence-free and overall survival in glioblastoma patients. We retrospectively identified patients undergo …

Hibar DP, Adams HHH, Jahanshad N, Chauhan G, Stein JL, Hofer E, Renteria ME, Bis JC, Arias-Vasquez A, Ikram MK, Desrivières S, Vernooij MW, Abramovic L, Alhusaini S, Amin N, Andersson M, Arfanakis K, Aribisala BS, Armstrong NJ, Athanasiu L, Axelsson T, Beecham AH, Beiser A, Bernard M, Blanton SH, Bohlken MM, Boks MP, Bralten J, Brickman AM, Carmichael O, Chakravarty MM, Chen Q, Ching CRK, Chouraki V, Cuellar-Partida G, Crivello F, Den Braber A, Doan NT, Ehrlich S, Giddaluru S, Goldman AL, Gottesman RF, Grimm O, Griswold ME, Guadalupe T, Gutman BA, Hass J, Haukvik UK, Hoehn D, Holmes AJ, Hoogman M, Janowitz D, Jia T, Jørgensen KN, Karbalai N, Kasperaviciute D, Kim S, Klein M, Kraemer B, Lee PH, Liewald DCM, Lopez LM, Luciano M, Macare C, Marquand AF, Matarin M, Mather KA, Mattheisen M, McKay DR, Milaneschi Y, Muñoz Maniega S, Nho K, Nugent AC, Nyquist P, Loohuis LMO, Oosterlaan J, Papmeyer M, Pirpamer L, Pütz B, Ramasamy A, Richards JS, Risacher SL, Roiz-Santiañez R, Rommelse N, Ropele S, Rose EJ, Royle NA, Rundek T, Sämann PG, Saremi A, Satizabal CL, Schmaal L, Schork AJ, Shen L, Shin J, Shumskaya E, Smith AV, Sprooten E, Strike LT, Teumer A, Tordesillas-Gutierrez D, Toro R, Trabzuni D, Trompet S, Vaidya D, Van der Grond J, Van der Lee SJ, Van der Meer D, Van Donkelaar MMJ, Van Eijk KR, Van Erp TGM, Van Rooij D, Walton E, Westlye LT, Whelan CD, Windham BG, Winkler AM, Wittfeld K, Woldehawariat G, Wolf C, Wolfers T, Yanek LR, Yang J, Zijdenbos A, Zwiers MP, Agartz I, Almasy L, Ames D, Amouyel P, Andreassen OA, Arepalli S, Assareh AA, Barral S, Bastin ME, Becker DM, Becker JT, Bennett DA, Blangero J, van Bokhoven H, Boomsma DI, Brodaty H, Brouwer RM, Brunner HG, Buckner RL, Buitelaar JK, Bulayeva KB, Cahn W, Calhoun VD, Cannon DM, Cavalleri GL, Cheng CY, Cichon S, Cookson MR, Corvin A, Crespo-Facorro B, Curran JE, Czisch M, Dale AM, Davies GE, De Craen AJM, De Geus EJC, De Jager PL, De Zubicaray GI, Deary IJ, Debette S, DeCarli C, Delanty N, Depondt C, DeStefano A, Dillman A, Djurovic S, Donohoe G, Drevets WC, Duggirala R, Dyer TD, Enzinger C, Erk S, Espeseth T, Fedko IO, Fernández G, Ferrucci L, Fisher SE, Fleischman DA, Ford I, Fornage M, Foroud TM, Fox PT, Francks C, Fukunaga M, Gibbs JR, Glahn DC, Gollub RL, Göring HHH, Green RC, Gruber O, Gudnason V, Guelfi S, Håberg AK, Hansell NK, Hardy J, Hartman CA, Hashimoto R, Hegenscheid K, Heinz A, Le Hellard S, Hernandez DG, Heslenfeld DJ, Ho BC, Hoekstra PJ, Hoffmann W, Hofman A, Holsboer F, Homuth G, Hosten N, Hottenga JJ, Huentelman M, Hulshoff Pol HE, Ikeda M, Jack CR Jr, Jenkinson M, Johnson R, Jönsson EG, Jukema JW, Kahn RS, Kanai R, Kloszewska I, Knopman DS, Kochunov P, Kwok JB, Lawrie SM, Lemaître H, Liu X, Longo DL, Lopez OL, Lovestone S, Martinez O, Martinot JL, Mattay VS, McDonald C, McIntosh AM, McMahon FJ, McMahon KL, Mecocci P, Melle I, Meyer-Lindenberg A, Mohnke S, Montgomery GW, Morris DW, Mosley TH, Mühleisen TW, Müller-Myhsok B, Nalls MA, Nauck M, Nichols TE, Niessen WJ, Nöthen MM, Nyberg L, Ohi K, Olvera RL, Ophoff RA, Pandolfo M, Paus T, Pausova Z, Penninx BWJH, Pike GB, Potkin SG, Psaty BM, Reppermund S, Rietschel M, Roffman JL, Romanczuk-Seiferth N, Rotter JI, Ryten M, Sacco RL, Sachdev PS, Saykin AJ, Schmidt R, Schmidt H, Schofield PR, Sigursson S, Simmons A, Singleton A, Sisodiya SM, Smith C, Smoller JW, Soininen H, Steen VM, Stott DJ, Sussmann JE, Thalamuthu A, Toga AW, Traynor BJ, Troncoso J, Tsolaki M, Tzourio C, Uitterlinden AG, Hernández MCV, Van der Brug M, van der Lugt A, van der Wee NJA, Van Haren NEM, van 't Ent D, Van Tol MJ, Vardarajan BN, Vellas B, Veltman DJ, Völzke H, Walter H, Wardlaw JM, Wassink TH, Weale ME, Weinberger DR, Weiner MW, Wen W, Westman E, White T, Wong TY, Wright CB, Zielke RH, Zonderman AB, Martin NG, Van Duijn CM, Wright MJ, Longstreth WT, Schumann G, Grabe HJ, Franke B, Launer LJ, Medland SE, Seshadri S, Thompson PM, Ikram MA. (2017) Novel genetic loci associated with hippocampal volume. Nat Commun. 2017 Jan 18;8:13624. doi: 10.1038/ncomms13624. PMID: 28098162 Free PMC article.
Further, we show that genetic variants associated with decreased hippocampal volume are also associated with increased risk for Alzheimer's disease (r(g)=-0.155). ...

Hinkelbein J, Iovino I, De Robertis E, Kranke P. (2017) Outcomes in video laryngoscopy studies from 2007 to 2017: systematic review and analysis of primary and secondary endpoints for a core set of outcomes in video laryngoscopy Research. BMC Anesthesiol. 2019 Apr 4;19(1):47. doi: 10.1186/s12871-019-0716-8. PMID: 30947694 Free PMC article.
Data were identified by using MEDLINE® database and the terms "video laryngoscopy" and "video laryngoscope" limited to the years 2007 to 2017. ...

Jelting Y, Klein C, Harlander T, Eberhart L, Roewer N, Kranke P. (2017) Preventing nausea and vomiting in women undergoing regional anesthesia for cesarean section: challenges and Solutions. Local Reg Anesth. 2017 Aug 9;10:83-90. doi: 10.2147/LRA.S111459. eCollection 2017. PMID: 28860857 Free PMC article. Review.
BACKGROUND: Intraoperative nausea and vomiting (IONV) or postoperative nausea and vomiting (PONV) affecting women undergoing regional anesthesia for cesarean section is an important clinical problem since these techniques are used widely. ...Performing a combined spinal-ep …

Kunz A, Klink T, Köhler S, Kellersmann R, Markus C, Bley T, Kickuth R. (2017) Interdisciplinary complication management of dislodged lumbar interbody spacer in pulmonary artery. BJR Case Rep. 2017 Nov 17;4(2):20170047. doi: 10.1259/bjrcr.20170047. eCollection 2018. PMID: 30363162 Free PMC article.

Roos-Hesselink JW, Budts W, Walker F, De Backer JFA, Swan L, Stones W, Kranke P, Sliwa-Hahnle K, Johnson MR. (2017) Organisation of care for pregnancy in patients with congenital heart disease. Heart. 2017 Dec;103(23):1854-1859. doi: 10.1136/heartjnl-2017-311758. Epub 2017 Jul 24. PMID: 28739807 Review.

Schnabel A, Reichl SU, Zahn PK, Pogatzki-Zahn EM, Meyer-Frießem CH. (2017) Efficacy and safety of buprenorphine in peripheral nerve blocks: A meta-analysis of randomised controlled Trials. Eur J Anaesthesiol. 2017 Sep;34(9):576-586. doi: 10.1097/EJA.0000000000000628. PMID: 28763315
OBJECTIVE(S): The aims of the current meta-analysis were to assess the efficacy and safety of the addition of perineural buprenorphine to local anaesthetic compared with local anaesthetic alone, or combined with systemic administration of buprenorphine, or other perineural …

Wahba AH, Hassan AM, Kotb M, ElShenoufy H, Haggag HM. (2017) Impact of Uterine Scar on Pain Experienced During Outpatient Hysteroscopy: A Prospective Blinded Comparative Study. J Minim Invasive Gynecol. 2017 May-Jun;24(4):626-631. doi: 10.1016/j.jmig.2017.01.018. Epub 2017 Feb 1. PMID: 28161494 Clinical Trial.
SETTING: Outpatient hysteroscopy clinic at a university hospital. PATIENTS: We included 140 women in the childbearing period attending an outpatient hysteroscopy clinic. ...INTERVENTION: Diagnostic outpatient hysteroscopy without the use of anesthesia or analgesia. …

Winkler BE, Muellenbach RM, Wurmb T, Struck MF, Roewer N, Kranke P. (2017) Passive continuous positive airway pressure ventilation during cardiopulmonary resuscitation: a randomized cross-over manikin simulation study. J Clin Monit Comput. 2017 Feb;31(1):93-101. doi: 10.1007/s10877-016-9836-6. Epub 2016 Feb 9. PMID: 26861639 Clinical Trial.

Publikationen 2016

Grundgeiger T, Albert M, Reinhardt D, Happel O, Steinisch A, Wurmb T. (2016) Real-time tablet-based resuscitation documentation by the team leader: evaluating documentation quality and clinical performance. Scand J Trauma Resusc Emerg Med 24:51.

Helms HC, Abbott NJ, Burek M, Cecchelli R, Couraud PO, Deli MA, Förster C, Galla HJ, Romero IA, Shusta EV, Stebbins MJ, Vandenhaute E, Weksler B, Brodin B. (2016) In vitro models of the blood-brain barrier: An overview of commonly used brain endothelial cell culture models and guidelines for their use. J Cereb Blood Flow Metab 36(5):862-90.

Jais A, Solas M, Backes H, Chaurasia B, Kleinridders A, Theurich S, Mauer J, Steculorum SM, Hampel B, Goldau J, Alber J, Förster CY, Eming SA, Schwaninger M, Ferrara N, Karsenty G, Brüning JC. (2016) Myeloid-Cell-Derived VEGF Maintains Brain Glucose Uptake and Limits Cognitive Impairment in Obesity. Cell 165(4):882-95.

Johannsen S, Treves S, Müller CR, Mögele S, Schneiderbanger D, Roewer N, Schuster F. (2016) Functional characterization of the RYR1 mutation p.Arg4737Trp associated with susceptibility to malignant hyperthermia. Neuromuscul Disord 26(1):21-5.

Klein KU, Johannes A, Brückner M, Thomas R, Matthews S, Frauenknecht K, Leukel P, Mazur J, Poplawski A, Muellenbach R, Sommer CJ, Thal SC, Engelhard K. (2016) Systemic PaO2 Oscillations Cause Mild Brain Injury in a Pig Model. Crit Care Med 44(5):e253-63.

Kranke P, Annecke T, Bremerich DH, Hanß R, Kaufner L, Klapp C, Ohnesorge H, Schwemmer U, Standl T, Weber S, Volk T. (2016) Anesthesia in obstetrics: Tried and trusted methods, current standards and new challenges. Anaesthesist 65(1):3-21.

Kumar N, Srivastava S, Burek M, Förster CY, Roy P. (2016) Assessment of estradiol-induced gene regulation and proliferation in an immortalized mouse immature Sertoli cell line. Life Sci 148:268-78.

Kunze E, Stetter C, Willner N, Koehler S, Kilgenstein C, Ernestus RI, Kranke P, Muellenbach RM, Westermaier T. (2016) Effects of Fluid Treatment With Hydroxyethyl Starch on Renal Function in Patients With Aneurysmal Subarachnoid Hemorrhage. J Neurosurg Anesthesiol 28(3):187-94.

Leinders M, Doppler K, Klein T, Deckart M, Rittner H, Sommer C, Üçeyler N. (2016) Increased cutaneous miR-let-7d expression correlates with small nerve fiber pathology in patients with fibromyalgia syndrome. Pain 157(11):2493-2503.

Lotz C, Roewer N, Muellenbach RM. (2016) Cardiac support and replacement therapies. Anasthesiol Intensivmed Notfallmed Schmerzther 51(9):564-72.

Lotz C, Roewer N, Muellenbach RM. (2016) Respiratory and extracorporeal lung support. Anasthesiol Intensivmed Notfallmed Schmerzther 51(9):574-81.

Mambretti EM, Kistner K, Mayer S, Massotte D, Kieffer BL, Hoffmann C, Reeh PW, Brack A, Asan E, Rittner HL. (2016) Functional and structural characterization of axonal opioid receptors as targets for analgesia. Mol Pain 12.

Marx G, Schindler AW, Mosch C, Albers J, Bauer M, Gnass I, Hobohm C, Janssens U, Kluge S, Kranke P, Maurer T, Merz W, Neugebauer E, Quintel M, Senninger N, Trampisch HJ, Waydhas C, Wildenauer R, Zacharowski K, Eikermann M. (2016) Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany. Eur J Anaesthesiol 33(7):488-521.

Rosenbaum C, Schick MA, Wollborn J, Heider A, Scholz CJ, Cecil A, Niesler B, Hirrlinger J, Walles H, Metzger M. (2016) Activation of Myenteric Glia during Acute Inflammation In Vitro and In Vivo. PLoS ONE 11(3):e0151335.

Schaefer MS, Kranke P, Weibel S, Kreysing R, Kienbaum P. (2016) Total intravenous anaesthesia versus single-drug pharmacological antiemetic prophylaxis in adults: A systematic review and meta-analysis. Eur J Anaesthesiol 33(10):750-60.

Shityakov S, Salmas RE, Durdagi S, Salvador E, Pápai K, Yáñez-Gascón MJ, Pérez-Sánchez H, Puskás I, Roewer N, Förster C, Broscheit JA. (2016) Characterization, in Vivo Evaluation, and Molecular Modeling of Different Propofol-Cyclodextrin Complexes To Assess Their Drug Delivery Potential at the Blood-Brain Barrier Level. J Chem Inf Model 56(10):1914-1922.

Shityakov S, Salmas RE, Salvador E, Roewer N, Broscheit J, Förster C. (2016) Evaluation of the potential toxicity of unmodified and modified cyclodextrins on murine blood-brain barrier endothelial cells. J Toxicol Sci 41(2):175-84.

Struck MF, Schmidt T, Winkler BE, Reinhart K, Schummer W. (2016) Formulas for prediction of insertion depths of internal jugular vein catheters adjusted to body height categories. J Vasc Access 17(2):191-4.

Stumpner J, Tischer-Zeitz T, Lotz C, Umminger J, Neuwirth A, Smul TM, Redel A, Kehl F, Roewer N, Lange M. (2016) The second window of desflurane-induced preconditioning is mediated by STAT3: role of Pim-1 kinase. Acta Anaesthesiol Scand 60(1):103-16.

Trudzinski FC, Minko P, Rapp D, Fähndrich S, Haake H, Haab M, Bohle RM, Flaig M, Kaestner F, Bals R, Wilkens H, Muellenbach RM, Link A, Groesdonk HV, Lensch C, Langer F, Lepper PM. (2016) Runtime and aPTT predict venous thrombosis and thromboembolism in patients on extracorporeal membrane oxygenation: a retrospective analysis. Ann Intensive Care 6(1):66.

Weibel S, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, Eberhart LH, Poepping DM, Afshari A, Kranke P. (2016) Efficacy and safety of intravenous lidocaine for postoperative analgesia and recovery after surgery: a systematic review with trial sequential analysis. Br J Anaesth 116(6):770-83.

Weibel S, Neubert K, Jelting Y, Meissner W, Wöckel A, Roewer N, Kranke P. (2016) Incidence and severity of chronic pain after caesarean section: A systematic review with meta-analysis. Eur J Anaesthesiol 33(11):853-865

Westermaier T, Stetter C, Kunze E, Willner N, Holzmeier J, Weiland J, Koehler S, Lotz C, Kilgenstein C, Ernestus RI, Roewer N, Muellenbach RM. (2016) Controlled Hypercapnia Enhances Cerebral Blood Flow and Brain Tissue Oxygenation After Aneurysmal Subarachnoid Hemorrhage: Results of a Phase 1 Study. Neurocrit Care 25(2):205-14.

Wurmb T, Brederlau J. (2016) Patients' declared intentions and emergency medicine. Med Klin Intensivmed Notfmed 111(2):113-7.

Yang S, Krug SM, Heitmann J, Hu L, Reinhold AK, Sauer S, Bosten J, Sommer C, Fromm M, Brack A, Rittner HL. (2016) Analgesic drug delivery via recombinant tissue plasminogen activator and microRNA-183-triggered opening of the blood-nerve barrier. Biomaterials 82:20-33.

Publikationen 2015

Artmann T, Gan TJ, Kranke P. (2015) Indications and limitations for colloids in interventions and surgery. Med Klin Intensivmed Notfmed 110(2):122-6.

Aust H, Kranke P, Eberhart LH, Afshari A, Weber F, Brieskorn M, Heine J, Arndt C, Rüsch D. (2015) Impact of medical training and clinical experience on the assessment of oxygenation and hypoxaemia after general anaesthesia: an observational study. J Clin Monit Comput 29(3):415-26.

Bennett MH, French C, Schnabel A, Wasiak J, Kranke P, Weibel S. (2015) Normobaric and hyperbaric oxygen therapy for the treatment and prevention of migraine and cluster headache. Cochrane Database Syst Rev 12:CD005219.

Brück S, Trautner H, Wolff A, Hain J, Mols G, Pakos P, Roewer N, Lange M. (2015) Comparison of the C-MAC(®) and GlideScope(®) videolaryngoscopes in patients with cervical spine disorders and immobilisation. Anaesthesia 70(2):160-5.

Dabrowski S, Staat C, Zwanziger D, Sauer RS, Bellmann C, Günther R, Krause E, Haseloff RF, Rittner H, Blasig IE. (2015) Redox-sensitive structure and function of the first extracellular loop of the cell-cell contact protein claudin-1: lessons from molecular structure to animals. Antioxid Redox Signal 22(1):1-14.

Doppler K, Rittner HL, Deckart M, Sommer C. (2015) Reduced dermal nerve fiber diameter in skin biopsies of patients with fibromyalgia. Pain 156(11):2319-25.

DuCanto J, Lungwitz Y, Koch A, Kähler W, Gessell L, Simanonok J, Roewer N, Kranke P, Winkler BE. (2015) Mechanical ventilation and resuscitation under water: Exploring one of the last undiscovered environments--A pilot study. Resuscitation 93:40-5.

Flemming S, Burkard N, Renschler M, Vielmuth F, Meir M, Schick MA, Wunder C, Germer CT, Spindler V, Waschke J, Schlegel N. (2015) Soluble VE-cadherin is involved in endothelial barrier breakdown in systemic inflammation and sepsis. Cardiovasc Res 107(1):32-44.

Fletcher D, Stamer UM, Pogatzki-Zahn E, Zaslansky R, Tanase NV, Perruchoud C, Kranke P, Komann M, Lehman T, Meissner W, euCPSP group for the Clinical Trial Network group of the European Society of Anaesthesiology. (2015) Chronic postsurgical pain in Europe: An observational study. Eur J Anaesthesiol 32(10):725-34.

Göb E, Bittner S, Bobak N, Kraft P, Göbel K, Langhauser F, Homola GA, Brede M, Budde T, Meuth SG, Kleinschnitz C. (2015) The two-pore domain potassium channel KCNK5 deteriorates outcome in ischemic neurodegeneration. Pflugers Arch 467(5):973-87.

Göb E, Reymann S, Langhauser F, Schuhmann MK, Kraft P, Thielmann I, Göbel K, Brede M, Homola G, Solymosi L, Stoll G, Geis C, Meuth SG, Nieswandt B, Kleinschnitz C. (2015) Blocking of plasma kallikrein ameliorates stroke by reducing thromboinflammation. Ann Neurol 77(5):784-803.

Grundgeiger T, Roewer N, Grundgeiger J, Hurtienne J, Happel O. (2015) Body posture during simulated tracheal intubation: GlideScope(®) videolaryngoscopy vs Macintosh direct laryngoscopy for novices and experts. Anaesthesia 70(12):1375-81.

Hopkins PM, Rüffert H, Snoeck MM, Girard T, Glahn KP, Ellis FR, Müller CR, Urwyler A, European Malignant Hyperthermia Group , Bandschapp O, Gillies R, Glauber V, Heytens L, Islander G, Klingler W, Kraft B, Krivosic-Horber R, Pollock N, Schuster F, Silva H, Sorrentino V, Street N, Tegazzin V, Tzanova I. (2015) European Malignant Hyperthermia Group guidelines for investigation of malignant hyperthermia susceptibility. Br J Anaesth 115(4):531-9.

Jokinen J, Adametz V, Kredel M, Muellenbach RM, Hönig A, Wöckel A, Dietl J, Roewer N, Kranke P. (2015) Spinal anesthesia in high-volume, low-concentration technique for Caesarean sections: Retrospective analysis. Anaesthesist 64(2):108-14.

Keller D, Lotz C, Kippnich M, Adami P, Kranke P, Roewer N, Kredel M, Schimmer C, Leyh R, Muellenbach RM. (2015) Venoarterial extracorporeal membrane oxygenation in an awake patient : Use of the mobile ECMO team for fulminant pulmonary embolism. Anaesthesist 64(5):385-9.

Kippnich M, Lotz C, Kredel M, Schimmer C, Weismann D, Sommer C, Kranke P, Roewer N, Muellenbach RM. (2015) Venoarterial extracorporeal membrane oxygenation for out-of-hospital cardiac arrest. Case series of prehospital and in-hospital therapies. Anaesthesist 64(8):580-5.

Kober C, Rohn S, Weibel S, Geissinger U, Chen NG, Szalay AA. (2015) Microglia and astrocytes attenuate the replication of the oncolytic vaccinia virus LIVP 1.1.1 in murine GL261 gliomas by acting as vaccinia virus traps. J Transl Med 13:216.

Konrad FM, Bury A, Schick MA, Ngamsri KC, Reutershan J. (2015) The unrecognized effects of phosphodiesterase 4 on epithelial cells in pulmonary inflammation. PLoS ONE 10(4):e0121725.

Kranke P, Bennett MH, Martyn-St James M, Schnabel A, Debus SE, Weibel S. (2015) Hyperbaric oxygen therapy for chronic wounds. Cochrane Database Syst Rev 6:CD004123.

Kranke P, Jokinen J, Pace NL, Schnabel A, Hollmann MW, Hahnenkamp K, Eberhart LH, Poepping DM, Weibel S. (2015) Continuous intravenous perioperative lidocaine infusion for postoperative pain and recovery. Cochrane Database Syst Rev 7:CD009642.

Kranke P, Thompson JP, Dalby PL, Eberhart LH, Novikova E, Johnson BM, Russ SF, Noble R, Brigandi RA. (2015) Comparison of vestipitant with ondansetron for the treatment of breakthrough postoperative nausea and vomiting after failed prophylaxis with ondansetron. Br J Anaesth 114(3):423-9.

Kredel M, Bierbaum D, Lotz C, Küstermann J, Roewer N, Muellenbach RM. (2015) Therapy of acute respiratory distress syndrome: Survey of German ARDS centers and scientific evidence. Anaesthesist 64(4):277-85.

Kurrek MM, Morgan P, Howard S, Kranke P, Calhoun A, Hui J, Kiss A. (2015) Simulation as a new tool to establish benchmark outcome measures in obstetrics. PLoS ONE 10(6):e0131064.

Lotz C, Kehl F. (2015) Volatile anesthetic-induced cardiac protection: molecular mechanisms, clinical aspects, and interactions with nonvolatile agents. J Cardiothorac Vasc Anesth 29(3):749-60.

Marx G, Schindler AW, Mosch C, Albers J, Bauer M, Gnass I, Hobohm C, Janssens U, Kluge S, Kranke P, Maurer T, Merz W, Neugebauer E, Quintel M, Senninger N, Trampisch HJ, Waydhas C, Wildenauer R, Zacharowski K, Eikermann M. (2015) Central venous pressure: evidence or expert opinion? Anaesthesist 64(12):975-976.

Metterlein T, Hartung E, Roewer N, Anetseder M. (2015) Effect of caffeine on intrinsic mechanical properties of normal and malignant hyperthermia-susceptible muscle. Muscle Nerve 52(4):580-3.

Metterlein T, Schuster F, Hager M, Roewer N, Anetseder M. (2015) Metabolic effects as a cause of myotoxic effects of fluoroquinolones. Indian J Pharmacol 47(6):616-9.

Meybohm P, Bein B, Brosteanu O, Cremer J, Gruenewald M, Stoppe C, Coburn M, Schaelte G, Böning A, Niemann B, Roesner J, Kletzin F, Strouhal U, Reyher C, Laufenberg-Feldmann R, Ferner M, Brandes IF, Bauer M, Stehr SN, Kortgen A, Wittmann M, Baumgarten G, Meyer-Treschan T, Kienbaum P, Heringlake M, Schön J, Sander M, Treskatsch S, Smul T, Wolwender E, Schilling T, Fuernau G, Hasenclever D, Zacharowski K, RIPHeart Study Collaborators , Stevanovic A, Rossaint R, Felzen M, Goetzenich A, Moormann T, Chalk K, Knuefermann P, Boehm O, Hoeft A, Winterhalter M, Iken S, Weber C, Wiedenbeck C, Schwarzmann G, Pense K, Zierer A, Fichtlscherer S, Goerlach G, Wollbrueck M, Boening U, Weigand M, Strauchmann J, August K, Morsbach KU, Paxian M, Reinhard K, Scholz J, Renner J, Broch O, Francksen H, Albrecht M, Kuhr B, Heinze H, Paarmann H, Sievers HH, Klotz S, Hachenberg T, Werner C, Mauff S, Alms A, Bergt S, Roewer N. (2015) A Multicenter Trial of Remote Ischemic Preconditioning for Heart Surgery. N Engl J Med 373(15):1397-407.

Neuhaus W, Schlundt M, Fehrholz M, Ehrke A, Kunzmann S, Liebner S, Speer CP, Förster CY. (2015) Multiple Antenatal Dexamethasone Treatment Alters Brain Vessel Differentiation in Newborn Mouse Pups. PLoS ONE 10(8):e0136221.

Rama-Maceiras P, Jokinen J, Kranke P. (2015) Stress and burnout in anaesthesia: a real world problem? Curr Opin Anaesthesiol 28(2):151-8.

Reinhold AK, Batti L, Bilbao D, Buness A, Rittner HL, Heppenstall PA. (2015) Differential transcriptional profiling of damaged and intact adjacent dorsal root ganglia neurons in neuropathic pain. PLoS ONE 10(4):e0123342.

Salvador E, Burek M, Förster CY. (2015) Stretch and/or oxygen glucose deprivation (OGD) in an in vitro traumatic brain injury (TBI) model induces calcium alteration and inflammatory cascade. Front Cell Neurosci 9:323.

Schick MA, Baar W, Bruno RR, Wollborn J, Held C, Schneider R, Flemming S, Schlegel N, Roewer N, Neuhaus W, Wunder C. (2015) Balanced Hydroxyethylstarch (HES 130/0.4) Impairs Kidney Function In-Vivo without Inflammation. PLoS ONE 10(9):e0137247.

Schnabel A, Reichl SU, Meyer-Frießem C, Zahn PK, Pogatzki-Zahn E. (2015) Tramadol for postoperative pain treatment in children. Cochrane Database Syst Rev 3:CD009574.

Schnabel A, Thyssen NM, Goeters C, Zheng H, Zahn PK, Van Aken H, Pogatzki-Zahn EM. (2015) Age- and procedure-specific differences of epidural analgesia in children--a database analysis. Pain Med 16(3):544-53.

Shityakov S, Puskás I, Pápai K, Salvador E, Roewer N, Förster C, Broscheit JA. (2015) Sevoflurane-Sulfobutylether-?-Cyclodextrin Complex: Preparation, Characterization, Cellular Toxicity, Molecular Modeling and Blood-Brain Barrier Transport Studies. Molecules 20(6):10264-79.

Shityakov S, Salvador E, Pastorin G, Förster C. (2015) Blood-brain barrier transport studies, aggregation, and molecular dynamics simulation of multiwalled carbon nanotube functionalized with fluorescein isothiocyanate. Int J Nanomedicine 10:1703-13.

Smul TM, Eilers H, Stumpner J. (2015) Nephroprotection--anaesthetic management of renal transplantation. Anasthesiol Intensivmed Notfallmed Schmerzther 50(9):566-75.

Steiger C, Wollborn J, Gutmann M, Zehe M, Wunder C, Meinel L. (2015) Controlled therapeutic gas delivery systems for quality-improved transplants. Eur J Pharm Biopharm 97(Pt A):96-106.

Stumpner J, Lange M, Roewer N, Kranke P, Smul TM. (2015) Perioperative myocardial protection in non-cardiac surgery. Anasthesiol Intensivmed Notfallmed Schmerzther 50(9):546-55.

Wiesmann T, Kranke P, Eberhart L. (2015) Postoperative nausea and vomiting - a narrative review of pathophysiology, pharmacotherapy and clinical management strategies. Expert Opin Pharmacother 16(7):1069-77.

Winkler B, Muth CM, Piepho T. (2015) Hyperbaric therapy and diving medicine - diving medicine - present state and prospects. Anasthesiol Intensivmed Notfallmed Schmerzther 50(10):638-45; quiz 646)

Winkler BE, Hartig F, DuCanto J, Koch A, Georgieff M, Lungwitz YP, Muth CM. (2015) Helicopter-based in-water resuscitation with chest compressions: a pilot study. Emerg Med J 32(7):553-8.

Wurmb T, Vollmer T, Sefrin P, Kraus M, Happel O, Wunder C, Steinisch A, Roewer N, Maier S. (2015) Monitoring of in-hospital cardiac arrest events with the focus on Automated External Defibrillators--a retrospective observational study. Scand J Trauma Resusc Emerg Med 23:87.

Publikationen 2014

Bennett MH, Weibel S, Wasiak J, Schnabel A, French C, Kranke P. (2014) Hyperbaric oxygen therapy for acute ischaemic stroke. Cochrane Database Syst Rev 11:CD004954.

Blecharz KG, Burek M, Bauersachs J, Thum T, Tsikas D, Widder J, Roewer N, Förster CY. (2014) Inhibition of proteasome-mediated glucocorticoid receptor degradation restores nitric oxide bioavailability in myocardial endothelial cells in vitro. Biol Cell 106(7):219-35.

Bruno RR, Neuhaus W, Roewer N, Wunder C, Schick MA. (2014) Molecular size and origin do not influence the harmful side effects of hydroxyethyl starch on human proximal tubule cells (HK-2) in vitro. Molecular size and origin do not influence the harmful side effects of hydroxyethyl starch on human proximal tubule cells (HK-2) in vitro. Anesth Analg 119(3):570-7.

Burek M, Steinberg K, Förster CY. (2014) Mechanisms of transcriptional activation of the mouse claudin-5 promoter by estrogen receptor alpha and beta. Mol Cell Endocrinol 392(1-2):144-51.

Eberhart L, Morin A, Kranke P. (2014) Nausea and vomiting after anaesthesia for children - Big problems for little patients. Anasthesiol Intensivmed Notfallmed Schmerzther49(1):24-9.

Enigk F, Wagner A, Samapati R, Rittner H, Brack A, Mousa SA, Schäfer M, Habazettl H, Schäper J. (2014) Thoracic epidural anesthesia decreases endotoxin-induced endothelial injury. BMC Anesthesiol 14:23.

Flemming S, Schlegel N, Wunder C, Meir M, Baar W, Wollborn J, Roewer N, Germer CT, Schick MA. (2014) Phosphodiesterase 4 inhibition dose dependently stabilizes microvascular barrier functions and microcirculation in a rodent model of polymicrobial sepsis. Shock 41(6):537-45.

Gan TJ, Diemunsch P, Habib AS, Kovac A, Kranke P, Meyer TA, Watcha M, Chung F, Angus S, Apfel CC, Bergese SD, Candiotti KA, Chan MT, Davis PJ, Hooper VD, Lagoo-Deenadayalan S, Myles P, Nezat G, Philip BK, Tramèr MR, Society for Ambulatory Anesthesia. (2014) Consensus guidelines for the management of postoperative nausea and vomiting. Anesth Analg 118(1):85-113.

Hoffmann J, Aleksic I, Smul TM, Leyh RG. (2014) Indications, risk factors, specialities and after-care of surgical treatment for cardiac and thoracic vascular diseases. Anasthesiol Intensivmed Notfallmed Schmerzther 49(1):40-8; quiz 49.

Honig A, Gehrmann M, Kranke P, Keller D, Engel JB, Hengstler S, Schmidt M. (2014) Microtubule-associated protein tau correlates with estrogen receptor status but not with in vitro paclitaxel sensitivity in primary breast cancer. Eur J Gynaecol Oncol 35(5):503-7.

Johannes A, Kredel M, Zollhoefer B, Schlegel N, von Kirschbaum C, Brederlau J, Kranke P, Roewer N, Muellenbach R. (2014) Influence of apneic oxygenation and minimal tidal volumes on ventilator-associated lung injury. Minerva Anestesiol 80(5):526-36.

Kippnich M, Keller D, Jokinen J, Kilgenstein C, Muellenbach RM, Markus C, Roewer N, Kranke P. (2014) From fishing trip to the critical care unit: Successful resuscitation after a near drowning accident.  Anaesthesist63(11):839-43.

Klingler W, Heiderich S, Girard T, Gravino E, Heffron JJ, Johannsen S, Jurkat-Rott K, Rüffert H, Schuster F, Snoeck M, Sorrentino V, Tegazzin V, Lehmann-Horn F. (2014) Functional and genetic characterization of clinical malignant hyperthermia crises: a multi-centre study. Orphanet J Rare Dis 9:8.

Kredel M, Lubnow M, Westermaier T, Müller T, Philipp A, Lotz C, Kilgenstein C, Küstermann J, Roewer N, Muellenbach RM. (2014) Cerebral tissue oxygenation during the initiation of venovenous ECMO. ASAIO J60(6):694-700.

Lazarus MG, Smul TM, Roewer N, Kranke P. (2014) Coagulation disorders in the context of cardiac surgery - Clinical basics and mechanism based therapy. Anasthesiol Intensivmed Notfallmed Schmerzther 49(1):50-8.

Liem DA, Nsair A, Setty SP, Cadeiras M, Wang D, Maclellan R, Lotz C, Lin AJ, Tabaraki J, Li H, Ge J, Odeberg J, Ponten F, Larson E, Mulder J, Lundberg E, Weiss JN, Uhlen M, Ping P, Deng MC. (2014) Molecular- and organelle-based predictive paradigm underlying recovery by left ventricular assist device support. Circ Heart Fail 7(2):359-66.

López CL, Meyer T, Heuer S, Kranke P, Debus F, Wurmb T, Kühne CA. (2014) In-hospital trauma management - beyond routine in trauma resuscitation. Anasthesiol Intensivmed Notfallmed Schmerzther 49(9):544-53; quiz 554.

López CL, Wurmb T, Mand C, Aigner R, Kühne CA. (2014) In-hospital trauma management - damage control. Anasthesiol Intensivmed Notfallmed Schmerzther 49(9):526-33; quiz 534.

Lotz C, Kranke P, Muellenbach RM. (2014) Venoarterial extracorporeal membrane oxygenation: be-all and end-all of cardiopulmonary support. Anaesthesist63(8-9):623-4.

Lotz C, Ritter O, Muellenbach RM. (2014) Assisted beating of the ischemic heart: how to manage the pulseless ST--segment-elevation myocardial infarction patient. Circulation 130(13):1095-104.

Lozovaya N, Gataullina S, Tsintsadze T, Tsintsadze V, Pallesi-Pocachard E, Minlebaev M, Goriounova NA, Buhler E, Watrin F, Shityakov S, Becker AJ, Bordey A, Milh M, Scavarda D, Bulteau C, Dorfmuller G, Delalande O, Represa A, Cardoso C, Dulac O, Ben-Ari Y, Burnashev N. (2014) Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nat Commun 5:4563.

Meierhofer JT, Anetseder M, Roewer N, Wunder C, Schwemmer U. (2014) Guidance of axillary multiple injection technique for plexus anesthesia. Ultrasound versus nerve stimulation. Anaesthesist 63(7):568-73.

Metterlein T, Schuster F, Graf BM, Anetseder M. (2014) Malignant hyperthermia. Anaesthesist 63(12):908-18.

Muellenbach R, Kilgenstein C, Kranke P, Küstermann J, Kredel M, Roewer N, Ernestus R, Westermaier T. (2014) Effects of venovenous extracorporeal membrane oxygenation on cerebral oxygenation in hypercapnic ARDS. Perfusion 29(2):139-41.

Nassen CA, Schaefer C, Wirbelauer J, Hönig A, Kranke P. (2014) Anesthesia and analgesia in the lactation period. Criteria for drug selection.  Anaesthesist 63(5):415-21.

Neuhaus W, Gaiser F, Mahringer A, Franz J, Riethmüller C, Förster C. (2014) The pivotal role of astrocytes in an in vitro stroke model of the blood-brain barrier. Front Cell Neurosci 8:352.

Novakova I, Subileau EA, Toegel S, Gruber D, Lachmann B, Urban E, Chesne C, Noe CR, Neuhaus W. (2014) Transport Rankings of Non-Steroidal Antiinflammatory Drugs across Blood-Brain Barrier In Vitro Models. PLoS ONE 9(1):e86806.

Roewer N, Kranke P. (2014) In Process Citation. Anasthesiol Intensivmed Notfallmed Schmerzther 49(1):36-9.

Roewer N, Kranke P. (2014) Inner trauma clinical management -- frequent is often and rare is rare ... but there are also "zebras". Anasthesiol Intensivmed Notfallmed Schmerzther49(9):522-5.

Salvador E, Shityakov S, Förster C. (2014) Routine follow-up cranial computed tomography for deeply sedated, intubated, and ventilated multiple trauma patients with suspected severe head injury. Biomed Res Int 2014:361949.

Sauer RS, Hackel D, Morschel L, Sahlbach H, Wang Y, Mousa SA, Roewer N, Brack A, Rittner HL. (2014) Toll like receptor (TLR)-4 as a regulator of peripheral endogenous opioid-mediated analgesia in inflammation. Mol Pain10:10.

Sauer RS, Krug SM, Hackel D, Staat C, Konasin N, Yang S, Niedermirtl B, Bosten J, Günther R, Dabrowski S, Doppler K, Sommer C, Blasig IE, Brack A, Rittner HL. (2014) Safety, efficacy, and molecular mechanism of claudin-1-specific peptides to enhance blood-nerve-barrier permeability. J Control Release185:88-98.

Schenk A, Markus CK, Kranke P. (2014) Awake fiberoptic intubation - gold standard for the anticipated difficult airway. Anasthesiol Intensivmed Notfallmed Schmerzther        49(2):92-9.

Schneiderbanger D, Johannsen S, Roewer N, Schuster F. (2014) Management of malignant hyperthermia: diagnosis and treatment. Ther Clin Risk Manag 10:355-62.

Schuster F, Johannsen S, Moegele S, Metterlein T, Roewer N, Anetseder M. (2014) The effect of succinylcholine on malignant hyperthermia events in susceptible swine. BMC Anesthesiol 14:14.

Shityakov S, Sohajda T, Puskás I, Roewer N, Förster C, Broscheit JA. (2014) Ionization states, cellular toxicity and molecular modeling studies of midazolam complexed with trimethyl- β-cyclodextrin. Molecules 19(10):16861-76.

Smul TM, Hoffmann J, Roewer N, Lazarus MG. (2014) Vascular cannulation and hemodynamic monitoring for cardiac and thoracic vascular surgery - a review. Anasthesiol Intensivmed Notfallmed Schmerzther 49(1):60-9.

Stammschulte T, Brune K, Brack A, Augenstein H, Arends G, Gundert-Remy U. (2014) Unexpected hemorrhage complications in association with celecoxib. Spontaneously reported case series after perioperative pain treatment in gynecological operations. Anaesthesist 63(12):958-60.

Wang Y, Gehringer R, Mousa SA, Hackel D, Brack A, Rittner HL. (2014) CXCL10 controls inflammatory pain via opioid peptide-containing macrophages in electroacupuncture. PLoS ONE 9(4):e94696.

Westermaier T, Stetter C, Kunze E, Willner N, Holzmeier J, Kilgenstein C, Lee JY, Ernestus RI, Roewer N, Muellenbach RM. (2014) Controlled transient hypercapnia: a novel approach for the treatment of delayed cerebral ischemia after subarachnoid hemorrhage? J Neurosurg 121(5):1056-62.

Wolfschmidt F, Dierks A, Wurmb T, Kickuth R, Kenn W. (2014) In-hospitaltraumamanagement - trauma suite diagnostics. Anasthesiol Intensivmed Notfallmed Schmerzther 49(9):536-42; quiz 543

Wurmb T, Kühne CA, Schneider R. (2014) In-hospitaltraumamanagement - radiation emergency and multiple trauma - principals of treatment in the emergency room. Anasthesiol Intensivmed Notfallmed Schmerzther 49(9):556-9.

Publikationen 2013

Bein T, Weber-Carstens S, Goldmann A, Müller T, Staudinger T, Brederlau J, Muellenbach R, Dembinski R, Graf BM, Wewalka M, Philipp A, Wernecke KD, Lubnow M, Slutsky AS. (2013) Lower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO2 removal versus 'conventional' protective ventilation (6 ml/kg) in severe ARDS: the prospective randomized Xtravent-study. Intensive Care Med 39(5):847-56.

Elias J, Heuschmann PU, Schmitt C, Eckhardt F, Boehm H, Maier S, Kolb-Mäurer A, Riedmiller H, Müllges W, Weisser C, Wunder C, Frosch M, Vogel U. (2013) Prevalence dependent calibration of a predictive model for nasal carriage of methicillin-resistant Staphylococcus aureus. BMC Infect Dis 13:111.

Hackel D, Pflücke D, Neumann A, Viebahn J, Mousa S, Wischmeyer E, Roewer N, Brack A, Rittner HL. (2013) The connection of monocytes and reactive oxygen species in pain. PLoS ONE 8(5):e63564.

Hahne JC, Meyer SR, Kranke P, Dietl J, Guckenberger M, Polat B, Hönig A. (2013) Studies on the role of osteopontin-1 in endometrial cancer cell lines. Strahlenther Onkol 189(12):1040-8.

Happel O, Roewer N, Kranke P. (2013) Helsinki Declaration on Patient Safety in Anaesthesiology--Part 8: SOP for checking equipment and drugs. Anasthesiol Intensivmed Notfallmed Schmerzther 48(9):538-42.

Johannes A, Zollhoefer B, Eujen U, Kredel M, Rauch S, Roewer N, Muellenbach RM. (2013) Deviation of tracheal pressure from airway opening pressure during high-frequency oscillatory ventilation in a porcine lung model. Exp Lung Res 39(3):130-5.

Johannsen S, Berberich C, Metterlein T, Roth C, Reiners K, Roewer N, Schuster F. (2013) Screening test for malignant hyperthermia in patients with persistent hyperCKemia: a pilot study. Muscle Nerve 47(5):677-81.

Johannsen S, Klingler W, Schneiderbanger D, Heiderich S, Roewer N, Schuster F. (2013) Sevoflurane is less sensitive than halothane for in vitro detection of malignant hyperthermia susceptibility. Acta Anaesthesiol  Scand 57(9):1161-6.

Kleinschnitz C, Kraft P, Dreykluft A, Hagedorn I, Göbel K, Schuhmann MK, Langhauser F, Helluy X, Schwarz T, Bittner S, Mayer CT, Brede M, Varallyay C, Pham M, Bendszus M, Jakob P, Magnus T, Meuth SG, Iwakura Y, Zernecke A, Sparwasser T, Nieswandt B, Stoll G, Wiendl H. (2013) Regulatory T cells are strong promoters of acute ischemic stroke in mice by inducing dysfunction of the cerebral microvasculature. Blood 121(4):679-91.

Kraft P, Göb E, Schuhmann MK, Göbel K, Deppermann C, Thielmann I, Herrmann AM, Lorenz K, Brede M, Stoll G, Meuth SG, Nieswandt B, Pfeilschifter W, Kleinschnitz C. (2013) FTY720 ameliorates acute ischemic stroke in mice by reducing thrombo-inflammation but not by direct neuroprotection. Stroke 44(11):3202-10.

Kraft P, Schwarz T, Göb E, Heydenreich N, Brede M, Meuth SG, Kleinschnitz C. (2013) The phosphodiesterase-4 inhibitor rolipram protects from ischemic stroke in mice by reducing blood-brain-barrier damage, inflammation and thrombosis. Exp Neurol 247:80-90.

Kranke P, Eberhart L, Motsch J, Chassard D, Wallenborn J, Diemunsch P, Liu N, Keh D, Bouaziz H, Bergis M, Fox G, Gan TJ. (2013) I.V. APD421 (amisulpride) prevents postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled, multicentre trial. Br J Anaesth 111(6):938-45.

Kranke P, Girard T, Lavand'homme P, Melber A, Jokinen J, Muellenbach RM, Wirbelauer J, Hönig A. (2013) Must we press on until a young mother dies? Remifentanil patient controlled analgesia in labour may not be suited as a "poor man's epidural". BMC Pregnancy Childbirth 13:139.

Küstermann J, Gehrmann A, Kredel M, Wurmb T, Roewer N, Muellenbach RM. (2013) Acute respiratory distress syndrome and septic cardiomyopathy : successful application of veno-venoarterial extracorporeal membrane oxygenation. Anaesthesist 62(8):639-43.

Meybohm P, Aken HV, Gasperi AD, Hert SD, Rocca GD, Girbes AR, Gombotz H, Guidet B, Hasibeder W, Hollmann MW, Ince C, Jacob M, Kranke P, Kozek-Langenecker S, Loer SA, Martin C, Siegemund M, Wunder C, Zacharowski K. (2013) Re-evaluating currently available data and suggestions for planning randomised controlled studies regarding the use of hydroxyethyl starch in critically ill patients - a multidisciplinary statement. Crit Care 17(4):R166.

Pflücke D, Hackel D, Mousa SA, Partheil A, Neumann A, Brack A, Rittner HL. (2013) The molecular link between C-C-chemokine ligand 2-induced leukocyte recruitment and hyperalgesia. J Pain 14(9):897-910.

Prinz M, Parlar S, Bayraktar G, Alptüzün V, Erciyas E, Fallarero A, Karlsson D, Vuorela P, Burek M, Förster C, Turunc E, Armagan G, Yalcin A, Schiller C, Leuner K, Krug M, Sotriffer CA, Holzgrabe U. 1,4-Substituted 4-(1H)-pyridylene-hydrazone-type inhibitors of AChE, BuChE, and amyloid-? aggregation crossing the blood-brain barrier. (2013) Eur J Pharm Sci 49(4):603-13.

Redel A, Hommers LG, Kranke P, Schwemmer U, Prasser C. (2013) Modification of perioperative psychiatric drug therapy. Anasthesiol Intensivmed Notfallmed Schmerzther 48(1):10-7.

Redel A, Stumpner J, Smul TM, Lange M, Jazbutyte V, Ridyard DG, Roewer N, Kehl F. (2013) Endothelial nitric oxide synthase mediates the first and inducible nitric oxide synthase mediates the second window of desflurane-induced preconditioning. J Cardiothorac Vasc Anesth 27(3):494-501.

Schnabel A, Reichl SU, Poepping DM, Kranke P, Pogatzki-Zahn EM, Zahn PK. (2013) Efficacy and safety of intraoperative dexmedetomidine for acute postoperative pain in children: a meta-analysis of randomized controlled trials. Paediatr Anaesth 23(2):170-9.

Schuster F, Johannsen S, Roewer N, Anetseder M. (2013) Minimally invasive monitoring of skeletal muscle hypermetabolism induced by the phosphodiesterase-III-inhibitor milrinone and sodium fluoride. J Pharm Pharmacol 65(4):547-51.

Schuster F, Johannsen S, Roewer N. (2013) Helsinki Declaration on Patient Safety in Anaesthesiology - Part 3: SOP for malignant hyperthermia. Anasthesiol Intensivmed Notfallmed Schmerzther 48(3):162-4.

Schuster F, Johannsen S, Schneiderbanger D, Roewer N. (2013) Evaluation of suspected malignant hyperthermia events during anesthesia. BMC Anesthesiol 13(1):24.

Shityakov S, Förster C. (2013) Pharmacokinetic delivery and metabolizing rate of nicardipine incorporated in hydrophilic and hydrophobic cyclodextrins using two-compartment mathematical model. ScientificWorldJournal 2013:131358.

Thal SC, Schaible EV, Neuhaus W, Scheffer D, Brandstetter M, Engelhard K, Wunder C, Förster CY. (2013) Inhibition of proteasomal glucocorticoid receptor degradation restores dexamethasone-mediated stabilization of the blood-brain barrier after traumatic brain injury. Crit Care Med 41(5):1305-15.

Van den Heuvel I, Wurmb TE, Böttiger BW, Bernhard M. (2013) Pros and cons of etomidate--more discussion than evidence? Curr Opin Anaesthesiol 26(4):404-8.

Voigt M, Fröhlich CW, Hüttel C, Kranke P, Mennen J, Boessneck O, Lenz C, Erbes T, Ernst J, Kerger H. (2013) Prophylaxis of intra- and postoperative nausea and vomiting in patients during cesarean section in spinal anesthesia. Med Sci Monit 19:993-1000.

Wang Y, Hackel D, Peng F, Rittner HL. (2013) Long-term antinociception by electroacupuncture is mediated via peripheral opioid receptors in free-moving rats with inflammatory hyperalgesia. Eur J Pain 17(10):1447-57.

Wasem S, Lazarus M, Hain J, Festl J, Kranke P, Roewer N, Lange M, Smul TM. (2013) Comparison of the Airtraq and the Macintosh laryngoscope for double-lumen tube intubation: a randomised clinical trial. Eur J Anaesthesiol 30(4):180-6.

Wasem S, Rifai M, Hönig A, Wirbelauer J, Roewer N, Kranke P. (2013) Should opioids be routinely used for the induction of general anaesthesia for caesarean section? Anasthesiol Intensivmed Notfallmed Schmerzther 48(6):374-7.

Publikationen 2012

Aust H, Eberhart LH, Kranke P, Arndt C, Bleimüller C, Zoremba M, Rüsch D. (2012) Hypoxemia after general anesthesia. Anaesthesist 61(4):299-309.

Betz B, Schneider R, Kress T, Schick MA, Wanner C, Sauvant C. (2012) Rosiglitazone affects nitric oxide synthases and improves renal outcome in a rat model of severe ischemia/reperfusion injury. PPAR Res 2012:219319.

Brederlau J, Küstermann J, Kredel M, Roewer N, Muellenbach RM. (2012) If the extracorporeal lung assist comes to its limit: use and management of extracorporeal membrane oxygenation in severe acute respiratory distress syndrome. Anasthesiol Intensivmed Notfallmed Schmerzther47(10):646-54.

Brevoord D, Kranke P, Kuijpers M, Weber N, Hollmann M, Preckel B. (2012) Remote ischemic conditioning to protect against ischemia-reperfusion injury: a systematic review and meta-analysis. PLoS ONE 7(7):e42179.

Dakwar GR, Kaplun V, Kojukarov L, Gorenbein P, Schumacher I, Kontorovich D, Förster C, Beit-Yannai E, Stepensky D. (2012) Toxicity assessment of extracts from infusion sets in cEND brain endothelial cells. Int J Pharm 434(1-2):20-7.

Dietz UA, Wichelmann C, Wunder C, Kauczok J, Spor L, Strauß A, Wildenauer R, Jurowich C, Germer CT. (2012) Early repair of open abdomen with a tailored two-component mesh and conditioning vacuum packing: a safe alternative to the planned giant ventral hernia. Hernia16(4):451-60.

Goebel S, Steinert AF, Schillinger J, Eulert J, Broscheit J, Rudert M, Nöth U. (2012) Reduced postoperative pain in total hip arthroplasty after minimal-invasive anterior approach. Int Orthop 36(3):491-8.

Hackel D, Brack A, Fromm M, Rittner HL. (2012) Modulation of tight junction proteins in the perineurium for regional pain control. Ann N Y Acad Sci1257:199-206.

Hackel D, Krug SM, Sauer RS, Mousa SA, Böcker A, Pflücke D, Wrede EJ, Kistner K, Hoffmann T, Niedermirtl B, Sommer C, Bloch L, Huber O, Blasig IE, Amasheh S, Reeh PW, Fromm M, Brack A, Rittner HL. (2012) Transient opening of the perineurial barrier for analgesic drug delivery. Proc Natl Acad Sci USA 109(29)E2018-27.

Häusler SF, Bernar T, Rau S, Kranke P, Dietl J, Rieger L. (2012) Severe maternal hepatopathies in the peripartum period--a case series with review of the literature focusing on pathogenesis and differential diagnosis. Z Geburtshilfe Neonatol 216(6):277-84.

Jazbutyte V, Stumpner J, Redel A, Lorenzen JM, Roewer N, Thum T, Kehl F. (2012) Aromatase inhibition attenuates desflurane-induced preconditioning against acute myocardial infarction in male mouse heart in vivo. PLoS ONE 7(8):e42032.

Johannsen S, Roewer N, Schuster F. (2012) The effects of colloid solutions on renal proximal tubular cells in vitro. Anesth Analg 114(2):371-4.

Kranke P, Röhm KD, Diemunsch P, Gan TJ, Apfel CC, Eberhart L, Minkowitz HS, Wallenborn J, Chassard D, Lebuffe G, Fox GM, Tramèr MR(2012) Intravenous buspirone for the prevention of postoperative nausea and vomiting. Eur J Clin Pharmacol 68(11):1465-72.

Kranke P. (2012) "Men are from Mars, women are from Venus": Gender medicine as a future must-have in anesthesiology? Anaesthesist 61(4):285-7.

Kredel M, Brederlau J, Wunder C, Wurmb TE, Kranke P, Roewer N, Muellenbach RM. (2012) High-frequency oscillatory ventilation with and without arteriovenous extracorporeal lung assist in patients with severe respiratory failure. J Crit Care 27(2):182-91.

Küstermann J, Brederlau J, Kranke P, Roewer N, Muellenbach RM. (2012) Ondansetron-induced muscular contractures in malignant hyperthermia-susceptible individuals. Anesth Analg 115(4):925-8.

Langhauser F, Göb E, Kraft P, Geis C, Schmitt J, Brede M, Göbel K, Helluy X, Pham M, Bendszus M, Jakob P, Stoll G, Meuth SG, Nieswandt B, McCrae KR, Kleinschnitz C. (2012) Kininogen deficiency protects from ischemic neurodegeneration in mice by reducing thrombosis, blood-brain barrier damage, and inflammation. Blood 120(19):4082-92.

Merker M, Dinges G, Koch T, Kranke P, Morin AM. (2012) Undesired side effects of tapentadol in comparison to oxycodone. A meta-analysis of randomized controlled comparative studies. Schmerz 26(1):16-26.

Meybohm P, Zacharowski K, Cremer J, Roesner J, Kletzin F, Schaelte G, Felzen M, Strouhal U, Reyher C, Heringlake M, Schön J, Brandes I, Bauer M, Knuefermann P, Wittmann M, Hachenberg T, Schilling T, Smul T, Maisch S, Sander M, Moormann T, Boening A, Weigand MA, Laufenberg R, Werner C, Winterhalter M, Treschan T, Stehr SN, Reinhart K, Hasenclever D, Brosteanu O, Bein B, RIP Heart-Study Investigator Group , Stoppe C, Krauss B, Eberhardt GF, Coburn M, Chalk K, Baumgarten G, Boehm O, Recht T, Köhlhoff K, Kessler F, Bhner T, Awlakpui E, Scheller B, Koch A, Bingold T, Fingerhut G, Goerlach G, Wollbrueck M, Strauchmann J, Morsbach KU, Scholz J, Renner J, Broch O, Gruenewald M, Albrecht M, Green M, Wehlen C, Messmer C, Schuldt C, Schleicher V, Hauer S, Bogatsch H, Scholze B, Sievers HH, Hanke T, Heinze H, Olsson S, Ettel J, von der Ecken M, Stitz P, Bremer J, Mauff S, Alms A, Bergt S. (2012) Remote ischaemic preconditioning for heart surgery. The study design for a multi-center randomized double-blinded controlled clinical trial--the RIPHeart-Study. Eur Heart J 33(12):1423-6.

Neuhaus W, Burek M, Djuzenova CS, Thal SC, Koepsell H, Roewer N, Förster CY. (2012) Addition of NMDA-receptor antagonist MK801 during oxygen/glucose deprivation moderately attenuates the upregulation of glucose uptake after subsequent reoxygenation in brain endothelial cells. Neurosci Lett 506(1):44-9.

Neuhaus W, Mandikova J, Pawlowitsch R, Linz B, Bennani-Baiti B, Lauer R, Lachmann B, Noe CR. (2012) Blood-brain barrier in vitro models as tools in drug discovery: assessment of the transport ranking of antihistaminic drugs. Pharmazie 67(5):432-9.

Neuhaus W, Samwer F, Kunzmann S, Muellenbach RM, Wirth M, Speer CP, Roewer N, Förster CY. (2012) Lung endothelial cells strengthen, but brain endothelial cells weaken barrier properties of a human alveolar epithelium cell culture model. Differentiation 84(4):294-304.

Neuhaus W, Schick MA, Bruno RR, Schneiker B, Förster CY, Roewer N, Wunder C. (2012) The effects of colloid solutions on renal proximal tubular cells in vitro. Anesth Analg 114(2):371-4.

Pace NL, Eberhart LH, Kranke PR. (2012) Quantifying prognosis with risk predictions. Eur J Anaesthesiol 29(1):7-16.

Rama-Maceiras P, Parente S, Kranke P. (2012) Job satisfaction, stress and burnout in anaesthesia: relevant topics for anaesthesiologists and healthcare managers? Eur J Anaesthesiol 29(7):311-9.

Rauch S, Johannes A, Zollhöfer B, Muellenbach RM. (2012) Evaluating intra-abdominal pressures in a porcine model of acute lung injury by using a wireless motility capsule. Med Sci Monit 18(5):BR163-6.

Rauch S, Krueger K, Turan A, You J, Roewer N, Sessler DI. (2012) Use of wireless motility capsule to determine gastric emptying and small intestinal transit times in critically ill trauma patients. J Crit Care 27(5):534.e7-534.e12.

Rittner HL, Amasheh S, Moshourab R, Hackel D, Yamdeu RS, Mousa SA, Fromm M, Stein C, Brack A. (2012) Modulation of tight junction proteins in the perineurium to facilitate peripheral opioid analgesia. Anesthesiology 116(6):1323-34

Schick MA, Isbary JT, Stueber T, Brugger J, Stumpner J, Schlegel N, Roewer N, Eichelbroenner O, Wunder C. (2012) Effects of crystalloids and colloids on liver and intestine microcirculation and function in cecal ligation and puncture induced septic rodents. BMC Gastroenterol 12:179.

Schick MA, Wunder C, Wollborn J, Roewer N, Waschke J, Germer CT, Schlegel N. (2012) Phosphodiesterase-4 inhibition as a therapeutic approach to treat capillary leakage in systemic inflammation. J Physiol590(Pt 11):2693-708.

Schnabel A, Hahn N, Broscheit J, Muellenbach RM, Rieger L, Roewer N, Kranke P. (2012) Remifentanil for labour analgesia: a meta-analysis of randomised controlled trials. Eur J Anaesthesiol 29(4):177-85.

Schnabel A, Schuster F, Ermert T, Eberhart LH, Metterlein T, Kranke P. (2012) Ultrasound guidance for neuraxial analgesia and anesthesia in obstetrics: a quantitative systematic review. Ultraschall Med 33(7):E132-7.

Schreiber JU, Lancé MD, de Korte M, Artmann T, Aleksic I, Kranke P. (2012) The effect of different lung-protective strategies in patients during cardiopulmonary bypass: a meta-analysis and semiquantitative review of randomized trials. J Cardiothorac Vasc Anesth 26(3):448-54.

Shityakov S, Broscheit J, Förster C. (2012) α-Cyclodextrin dimer complexes of dopamine and levodopa derivatives to assess drug delivery to the central nervous system: ADME and molecular docking studies. Int J Nanomedicine 7:3211-9.

Stumpner J, Lange M, Beck A, Smul TM, Lotz CA, Kehl F, Roewer N, Redel A. (2012) Desflurane-induced post-conditioning against myocardial infarction is mediated by calcium-activated potassium channels: role of the mitochondrial permeability transition pore. Br J Anaesth 108(4):594-601.

Stumpner J, Smul TM, Redel A, Hilz T, Tischer-Zeitz T, Eisenbarth H, Schick MA, Kehl F, Roewer N, Lange M. (2012) Desflurane-induced and ischaemic postconditioning against myocardial infarction are mediated by Pim-1 kinase. Acta Anaesthesiol Scand        56(7):904-13.

Turan A, Dalton JE, Kasuya Y, Akça O, Sessler DI, Rauch S. (2012) Correlation between bispectral index, observational sedation scale, and lower esophageal sphincter pressure in volunteers using dexmedetomidine or propofol. Med Sci Monit 18(10):CR593-6.

Wurmb T, Roewer N. (2012) Physician-patient-family relationship-a core element of a successful intensive care therapy? Dtsch Med Wochenschr 137(1-2):41-5.

Zwanziger D, Hackel D, Staat C, Böcker A, Brack A, Beyermann M, Rittner H, Blasig IE. (2012) A peptidomimetic tight junction modulator to improve regional analgesia. Mol Pharm 9(6):1785-94.

Kontakt, Öffnungszeiten, Sprechzeiten


Prof. Dr. med. Patrick Meybohm
+49 931 201-30001




+49 931 201-30019


Klinik und Poliklinik für Anästhesiologie, Intensivmedizin und Schmerztherapie | Zentrum Operative Medizin (ZOM) | Oberdürrbacher Straße 6 | Haus A2 | 97080 Würzburg | Deutschland