Publikationen Pädiatrische Onkologie, Hämatologie und Stammzelltransplantation

2017

Andres O, Henning K, Strauß G, Pflug A, Manukjan G, Schulze H. (2017) Diagnosis of platelet function disorders: A standardised, rational and modular flow cytometric approach. Platelets 11:1-10 Epub.

Andres O, Wiegering V, König EM, Schneider AL, Stritt S, Klopocki E, Schulze H. (2017) A novel two-nucleotide deletion in HPS6 affects mepacrine uptake and platelet dense granule secretion in a family with Hermansky-Pudlak syndrome. Pediatr Blood Cancer 64 (5).

Hartwell MJ, Özbek U, Ernst Holler E, Renteria AS, Major-Monfried H, Reddy P, Aziz M, Hogan WJ, Ayuk F, Efebera YA, Hexner EO, Bunworasate U, Qayed M, Ordemann R, Wölfl M, Mielke S, Pawarode A, Chen YB, Devine S, Harris AC, Jagasia M, Kitko CL, Litzow MR, Kröger N, Locatelli F, Morales G, Reshef RR, Rösler W, Weber D, Wudhikarn K, Yanik GA, Levine JE, Ferrara JLM. (2017) An Early Biomarker Algorithm Predicts Lethal Graft -versus- Host Disease and Survival. JCI Insights 2(3):e89798.

Hellmann AM, Lother J, Wurster S, Lutz MB, Schmitt AL, Morton CO, Eyrich M, Czakai K, Einsele H, Loeffler J. (2017) Human and Murine Innate Immune Cell Populations Display Common and Distinct Response Patterns during Their In Vitro Interaction with the Pathogenic Mold Aspergillus fumigatus. Front Immunol 8:1716.

Kredel M, Kunzmann S, Schlegel PG, Wölfl M, Nordbeck P, Bühler C, Lotz C, Lepper P, Wirbelauer J, Roewer N, Muellenbach RM. (2017) Double peripheral veno-arterial cannulation with transseptal left atrial discharge for extracorporeal membrane oxygenation in combined septic and cardiogenic shock. Am J Case Rep 18:723-727.

Loewecke F, Andres O, Eber S. (2017) Anämiediagnostik ‒ Alte und neue Parameter. Kinder- und Jugendmedizin 27(2): 93-104.

Reichel A, Hamm H, Wiegering V, Wiewrodt B, Neubauer H, Ernestus K, Winkler B. (2017) Kaposiform hemangioendothelioma with Kasabach-Merritt syndrome: successful treatment with sirolimus. J Dtsch Dermatol Ges 15(3):329-331. Epub 2017 Feb 21. No abstract available.

Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote AL, Potter SJ, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan C, Eyrich M, Hermanns HM, Geissler EK, Lutz MB. (2017) Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function. Blood Adv 1(14):947-960.

Schulze H, Schlagenhauf A, Manukjan G, Beham-Schmid C, Andres O, Klopocki E, König EM, Haidl H, Panzer S, Althaus K, Muntean WE, Schwinger W, Urban C, Greinacher A, Bakchoul T, Seidel MG. (2017) Recessive grey platelet-like syndrome with unaffected erythropoiesis in the absence of the Splice Isoform GFI1B-p37. Haematologica. Epub.

2016

Bartelheim K, Nemes K, Seeringer A, Kerl K, Buechner J, Boos J, Graf N, Dürken M, Gerss J, Hasselblatt M, Kortmann RD, Teichert von Luettichau I, Nagel I, Nygaard R, Oyen F, Quiroga E, Schlegel PG, Schmid I, Schneppenheim R, Siebert R, Solano-Paez P, Timmermann B, Warmuth-Metz M, & Frühwald MC. (2016) Improved 6-year overall survival in AT/RT – results of the registry study Rhabdoid 2007. Cancer Med 5(8):1765-75.

Braun M, Ress ML, Yoo Y-E, Scholz CJ, Eyrich M, Schlegel PG and Wölfl M. (2016) IL 12-mediated sensitizing of T-cell receptor-dependent and –independent tumor cell killing. Oncoimmunology 5(7):e1188245. doi: 10.1080/2162402X.2016.1188245.

Dietl S, Schwinn S, Dietl S, Riedel S, Deinlein F, Rutkowski S, von Bueren AO, Krauss J, Schweitzer T, Vince GH, Picard D, Eyrich M, Rosenwald A, Ramaswamy V, Taylor MD, Remke M, Monoranu CM, Beilhack A, Schlegel PG, Wölfl M. (2016) MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell- and Group 3-properties. BMC Cancer 16:115.

Eber S, Andres O. (2016) Anämien. Monatsschr Kinderheilkd 164(1):59-72.

Eber S. W., Andres O. (2016) Hereditäre Sphärozytose, S1-Leitlinie 025/018. AWMF 12/2016, 1-26.

Harris AC, Young R, Devine S, Hogan WJ, Ayuk F, Bunworasate U, Chanswangphuwana C, Efebera YA, Holler E, Litzow M, Ordemann R, Qayed M, Renteria AS, Reshef R, Wölfl M, Chen YB, Goldstein S, Jagasia M, Locatelli F, Mielke S, Porter D, Schechter T, Shekhovtsova Z, Ferrara JL, Levine JE. (2016) International, Multicenter Standardization of Acute Graft-versus-Host Disease Clinical Data Collection: A Report from the Mount Sinai Acute GVHD International Consortium. Biol Blood Marrow Transplant. 22(1):4-10.

Hartz B. Marsh R, Rao K, Henter JI, Jordan M, Filipovich L, Dabder P, Beier R, Burkhardt B, Meisel R, Schulz A, Winkler B, Albert MH, Greil J, Karasu G, Woessmann W, Corbacioglu S, Gruhn B, Holter W, Kühl JS, Lang P, Seidel MG, Veys P, Löfstedt A, Ammann S, Ehl S, Janka G, Müller I, Lehmberg K. (2016) The minimum required level of donor chimerism in hereditary hemophagocytic lymphohistiocytosis. Blood. 2016;127(25):3281-90.

Loeffler J, Hafner J, Mengoli C, Wirth C, Heussel CP, Löffler C, White PL, Ullmann AJ, Michel D, Wiegering V, Wölfl M, Schlegel PG, Einsele H, Springer J, Eyrich M. (2016) Prospective Biomarker Screening for Diagnosis of Invasive Aspergillosis in High-Risk Pediatric Patients. J Clin Microbiol. 55(1):101-109.

Müller I, Altherr D, Eyrich M, Flesch B, Friedmann KS, Ketter R, Oertel J, Schwarz EC, Technau A, Urbschat S, Eichler H. (2016) Tumor antigen-specific T cells for immune monitoring of dendritic cell-treated glioblastoma patients. Cytotherapy 1146-61.

Neubauer H, Wölfl M, Ernestus K. (2016) Dermatom und Diffusion--Diagnostik und Therapiekontrolle eines undifferenzierten embryonalen Sarkoms der Leber. Rofo 188(4):389-91.

Streng A, Wiegering V, Liese JG. (2016) Varicella in pediatric oncology patients in the post-vaccine era-Analysis of routine hospital data from Bavaria (Germany), 2005-2011. Pediatric hematology and oncology 33(7-8):468-479.

van Gool SW, Holm S, Rachor J, Adamson L, Technau A, Maass E, Frühwald MC, Schlegel PG, Eyrich M (2016): Immunotherapy in atypical teratoid-rhabdoid tumors: Data from a survey of the HGG-Immuno Group. Cytotherapy 18(9):1178-86.

von Bueren AO, Kortmann RD, von Hoff K, Friedrich C, Mynarek M, Müller K, Goschzik T, Zur Mühlen A, Gerber N, Warmuth-Metz M, Soerensen N, Deinlein F, Benesch M, Zwiener I, Kwiecien R, Faldum A, Bode U, Fleischhack G, Hovestadt V, Kool M, Jones D, Northcott P, Kuehl J, Pfister S, Pietsch T, Rutkowski S. (2016) Treatment of Children and Adolescents With Metastatic Medulloblastoma and Prognostic Relevance of Clinical and Biologic Parameters. J Clin Oncol 34(34):4151-4160.

von Stackelberg A, Locatelli F, Zugmaier G, Handgretinger R, Trippett TM, Rizzari C, Bader P, O'Brien MM, Brethon B, Bhojwani D, Schlegel PG, Borkhardt A, Rheingold SR, Cooper TM, Zwaan CM, Barnette P, Messina C, Michel G, DuBois SG, Hu K, Zhu M, Whitlock JA, Gore L. (2016) Phase I/Phase II Study of Blinatumomab in Pediatric Patients With Relapsed/Refractory Acute Lymphoblastic Leukemia. J Clin Oncol 34(36):4381-4389.

Weber ML, Schneider DT, Offenmüller S, Kaatsch P, Einsiedel HG, Benesch M, Claviez A, Ebinger M, Kramm C, Kratz C, Lawlor J, Leuschner I, Merkel S, Metzler M, Nustede R, Petsch S, Seeger KH, Schlegel PG, Suttorp M, Zolk O, Brecht IB. (2016) Pediatric colorectal carcinoma is associated with excellent outcome in the context of cancer predisposition syndromes. Ped Blood Cancer 63(4):611-617.

Zipfel J, Eyrich M, Schlegel P-G, Wiegering V. (2016) Disturbed B cell and DC-Homeostasis in Pediatric cGVHD Patients-Cocultivation Experiments and Review of the Literature. Clin Oncol 1:1097.

Zlamy M, Almanzar G, Parson W, Schmidt C, Leierer J, Weinberger B, Jeller V, Unsinn K, Eyrich M, Würzner R, Prelog M. (2016) Efforts of the human immune system to maintain the peripheral CD8+ T cell compartment after childhood thymectomy. Immun Ageing 13:3.

2015

Andres O, Schulze H, Speer CP. (2015) Platelets in neonates: central mediators in haemostasis, antimicrobial defence and inflammation. Thromb Haemost 113(1):3-12.

Chao MM, Ebell W, Bader P, Beier R, Burkhardt B, Feuchtinger T, Handgretinger R, Hanenberg H, Koehl U, Kratz C, Kremens B, Lang P, Meisel R, Mueller I, Roessig C, Sauer M, Schlegel PG, Schulz A, Strahm B, Thol F, Sykora KW. (2015) Consensus of German Transplant Centers on Hematopoietic Stem Cell Transplantation in Fanconi Anemia. Klin Padiatr 227(3):157-165.

Feucht J, Opherk K, Lang P, Kayser S, Hartl L, Bethge W, Matthes-Martin S, Bader P, Albert MH, Maecker-Kolhoff B, Greil J, Einsele H, Schlegel PG, Schuster FR, Kremens B, Rossig C, Gruhn B, Handgretinger R, Feuchtinger T. (2015) Adoptive T-cell therapy with hexon-specific Th1 cells as a treatment of refractory adenovirus infection after HSCT. Blood 125(12):1986-94.

Hellwig Y, Yoo YE, Reß ML, Andres O, Braun M, Schlegel PG, Wölfl M. (2015) Fulminant skin GvHD with a cytokine pattern resemblant of cytokine release syndrome successfully treated with multimodal immunosuppression including tocilizumab. Pediatr Blood Cancer 2015 Nov. 62(11):2033-5.

Herbst M, Gazendam R, Reimnitz D, Sawalle-Belohradsky J, Groll A, Schlegel PG, Belohradsky B, Renner E, Klepper J, Grimbacher B, Kuijpers T, Liese J. (2015) Chronic Candida albicans Meningitis in a 4-Year-Old Girl with a Homozygous Mutation in the CARD9 Gene (Q295X). Pediatr Infect Dis J. 34(9):999-1002.

Li M, Winkler B, Pabst T, Bley T, Köstler H, Neubauer H. (2015) Fast MR Imaging of the Paediatric Abdomen with CAIPIRINHA-Accelerated T1w 3D FLASH and with High-Resolution T2w HASTE: A Study on Image Quality. Gastroenterol Res Pract 2015:693654.

Nowak J, Löbel U, Wölfl M, Schlegel PG, Warmuth-Metz M. (2015) MRI demyelination pattern and clinical course in a child with cerebral X-linked adrenoleukodystrophy (X-ALD). Acta Radiol Open 4(4):2047981615573655.

Ottensmeier H, Zimolong B, Wolff JE, Ehrich J, Galley N, von Hoff K, Kuehl J, Rutkowski S. (2015) Neuropsychological short assessment of disease- and treatment-related intelligence deficits in children with brain tumours. Eur J Paediatr Neurol 19(3):298-307.

Pompe RS, von Bueren AO, Mynarek M, von Hoff K, Friedrich C, Kwiecien R, Treulieb W, Lindow C, Deinlein F, Fleischhack G, Kuehl J, Rutkowski S. (2015) Intraventricular methotrexate as part of primary therapy for children with infant and/or metastatic medulloblastoma: Feasibility, acute toxicity and evidence for efficacy. Eur J Cancer 2015;51(17):2634-42.

Sandrock-Lang, K., J. Oldenburg, V. Wiegering, S. Halimeh, S. Santoso, K. Kurnik, L. Fischer, D. A. Tsakiris, M. Sigl-Kraetzig, B. Brand, M. Buhrlen, K. Kraetzer, N. Deeg, M. Hund, E. Busse, A. Kahle and B. Zieger. (2015) Characterisation of patients with Glanzmann thrombasthenia and identification of 17 novel mutations. Thromb Haemost 113:782.

Schuster FR, Stanglmaier M, Woessmann W, Winkler B, Siepermann M, Meisel R, Schlegel PG, Hess J, Lindhofer H, Borkhardt A, Buhmann R. (2015) Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies. Br J Haematol 169(1):90-102.

Schilbach, K., M. Alkhaled, C. Welker, F. Eckert, G. Blank, H. Ziegler, M. Sterk, F. Müller, K. Sonntag, T. Wieder, H. Braumüller, J. Schmitt, M. Eyrich, S. Schleicher, C. Seitz, A. Erbacher, B.J. Pichler, H. Müller, R. Tighe, A. Lim, S.D. Gillies, W. Strittmatter, M. Röcken. (2015) Cancer-targeted IL-12 controls human rhabdomyosarcoma by senescence induction and myogenic differentiation. OncoImmunology 4:7, e1014760.

Schmitt J, Eckardt S, Schlegel PG, Sirén AL, Bruttel VS, Mclaughlin KJ, Wischhusen J, Müller AM. (2015) Human parthenogenetic embryonic stem cell-derived neural stem cells express HLA-G and show unique resistance to NK cell-mediated killing. Mol Med 21:185-96.

Tallen G, Resch A, Calaminus G, Wiener A, Leiss U, Pletschko T, Friedrich C, Langer T, Grabow D, Driever PH, Kortmann RD, Timmermann B, Pietsch T, Warmuth-Metz M, Bison B, Thomale UW, Krauss J, Mynarek M, von Hoff K, Ottensmeier H, Frühwald M, Kramm CM, Temming P, Müller HL, Witt O, Kordes U, Fleischhack G, Gnekow A, Rutkowski S. (2015) Strategies to improve the quality of survival for childhood brain tumour survivors. Eur J Paediatr Neurol 19(6):619-39.

Veys PA, Nanduri V, Baker KS, He W, Bandini G, Biondi A, Dalissier A, Davis JH, Eames GM, Egeler RM, Filipovich AH, Fischer A, Jürgens H, Krance R, Lanino E, Leung WH, Matthes S, Michel G, Orchard PJ, Pieczonka A, Ringdén O, Schlegel PG, Sirvent A, Vettenranta K, Eapen M. (2015) Haematopoietic stem cell transplantation for refractory Langerhans cell histiocytosis: outcome by intensity of conditioning. Br J Haematol 169(5):711-8.

von Bueren AO, Friedrich C, von Hoff K, Kwiecien R, Müller K, Pietsch T, Warmuth-Metz M, Hau P, Benesch M, Kuehl J, Kortmann RD, Rutkowski S. (2015) Metastatic medulloblastoma in adults: outcome of patients treated according to the HIT2000 protocol. Eur J Cancer. 51(16):2434-43.

Wiegering, A., M. Kunz, M. Hussein, I. Klein, V. Wiegering, F. W. Uthe, U. A. Dietz, C. Jurowich, T. Bley, T. Dandekar, C. T. Germer and C. Ritter. (2015) Diagnostic value of preoperative CT scan to stratify colon cancer for neoadjuvant therapy. Int J Colorectal Dis. 30(8):1067-73.

Wiegering, V. A., I. Klein, C. Wirth, A. Dick, T. Meyer, P. G. Schlegel and A. Wiegering. (2015) Anemia and B Symptoms as Leading Symptoms for a Hepatic Inflammatory Pseudotumor - 2 Case Reports. Klin Padiatr 227(6-7):363-5.

Winkler, B., J. Aulenbach, T. Meyer, A. Wiegering, M. Eyrich, P. G. Schlegel and V. Wiegering (2015): Formula-feeding is associated with shift towards Th1 cytokines. Eur J Nutr 54:129.

Winkler, B., J. Taschik, I. Haubitz, M. Eyrich, P. G. Schlegel and V. Wiegering. (2015) TGFbeta and IL10 have an impact on risk group and prognosis in childhood ALL. Pediatr Blood Cancer 62:72.

Zils K, Klingebiel T, Behnisch W, Mueller HL, Schlegel PG, Fruehwald M, Suttorp M, Simon T, Werner M, Bielack S. (2015) Osteosarcoma in patients with Rothmund-Thomson syndrome. Pediatr Hematol Oncol. 32(1):32-40.

2014

Benesch M, Bartelheim K, Fleischhack G, Gruhn B, Schlegel PG, Witt O, Stachel KD, Hauch H, Urban C, Quehenberger F, Massimino M, Pietsch T, Hasselblatt M, Giangaspero F, Kordes U, Schneppenheim R, Hauser P, Klingebiel T, Frühwald MC. (2014) High-dose chemotherapy (HDCT) with auto-SCT in children with atypical teratoid/rhabdoid tumors (AT/RT): a report from the European Rhabdoid Registry (EU-RHAB). Bone Marrow Transplant 49(3):370-5.

Braun M, Wölfl M, Wiegering V, Winkler B, Ertan K, Bald R, Schwarz K, Heimpel H, Eyrich M, Schlegel PG. (2014) Successful treatment of an infant with CDA type II by intrauterine transfusions and postnatal stem cell transplantation. Pediatr Blood Cancer 61:743-5.

Chandran PA, Keller A, Weinmann L, Seida AA, Braun M, Andreev K, Fischer B, Horn E, Schwinn S, Junker M, Houben R, Dombrowski Y, Dietl J, Finotto S, Wölfl M, Meister G, Wischhusen J. (2014) The TGF-β-inducible miR-23a cluster attenuates IFN-γ levels and antigen-specific cytotoxicity in human CD8⁺ T cells. J Leukoc Biol 2014 Oct;96(4):633-45.

Eyrich M. (2014) Case 19: A one year old boy with SCID. In: Kröger, N, Aversa F (eds): 34 successful treatment reports. Thieme 2014.

Eyrich, M., S.C. Schreiber, J. Rachor, J. Krauß , F. Pauwels, J. Hain, M. Wölfl,  M.B. Lutz, S. de Vleeschouwer, P.G. Schlegel, S.W. Van Gool. (2014) Development and validation of a fully GMP-compliant production process of autologous, tumor-lysate pulsed dendritic cells. Cytotherapy 16:946.

Fink S, Kunzmann S, Andres O, Eyrich M, Wiegering V. (2014) Haemophilia in extreme immature preterm infants: increased risk for intracranial haemorrhage? J Matern Fetal Neonatal Med 27:621-4.

Gerber NU, von Hoff K, Resch A, Ottensmeier H, Kwiecien R, Faldum A, Matuschek C, Hornung D, Bremer M, Benesch M, Pietsch T, Warmuth-Metz M, Kuehl J, Rutkowski S, Kortmann RD. (2014) Treatment of children with central nervous system primitive neuroectodermal tumors/pinealoblastomas in the prospective multicentric trial HIT 2000 using hyperfractionated radiation therapy followed by maintenance chemotherapy. Int J Radiat Oncol Biol Phys 89(4):863-71.

Güngör T, Teira P, Slatter M, Stussi G, Stepensky P, Moshous D, Vermont C, Ahmad I, Shaw PJ, da Cunha JM, Schlegel PG, Hough R, Fasth A, Kentouche K, Gruhn B, Fernandes JF, Lachance S, Bredius R, Resnick IB, Belohradsky BH, Gennery A, Fischer A, Gaspar HB, Schanz U, Seger R, Rentsch K, Veys P, Haddad E, Albert MH, Hassan M; on behalf of the Inborn Errors Working Party of the European Society for Blood and Marrow Transplantation. (2014) Reduced-intensity conditioning and HLA-matched haemopoietic stem-cell transplantation in patients with chronic granulomatous disease: a prospective multicentre study. Lancet 383:436-48.

Hassold N, Warmuth-Metz M, Winkler B, Kreissl MC, Ernestus K, Beer M, Neubauer H. (2014) Hit the mark with diffusion-weighted imaging: metastases of rhabdomyosarcoma to the extraocular eye muscles. BMC Pediatr 14:57.

Illhardt T, Ebinger M, Schwarze CP, Feuchtinger T, Furtwängler R, Schlegel PG, Klingebiel T, Greil J, Beck JF, Handgretinger R, Lang P. (2014) Children with relapsed or refractory nephroblastoma: favorable long-term survival after high-dose chemotherapy and autologous stem cell transplantation. Klin Padiatr 226(6-7):351-6.

Schuster FR, Stanglmaier M, Woessmann W, Winkler B, Siepermann M, Meisel R, Schlegel PG, Hess J, Lindhofer H, Borkhardt A, Buhmann R. (2014) Immunotherapy with the trifunctional anti-CD20 x anti-CD3 antibody FBTA05 (Lymphomun) in paediatric high-risk patients with recurrent CD20-positive B cell malignancies. Br J Haematol. Epub ahead of print.

Streif, W., R. Knofler, W. Eberl, O. Andres, T. Bakchoul, F. Bergmann, K. Beutel, R. Dittmer, S. Gehrisch, S. Gottstein, S. Halimeh, J. Haselbock, W. A. Hassenpflug, S. Heine, S. Holzhauer, S. King, C. M. Kirchmaier, M. Krause, W. Kreuz, W. Losche, R. Mahnel, M. Maurer, A. Nimtz-Talaska, M. Olivieri, H. Rott, M. Schambeck Ch, A. Schedel, F. H. Schilling, M. Schmugge, R. Schneppenheim, U. Scholz, T. Scholz, H. Schulze, A. Siegemund, G. Strauss, K. W. Sykora, C. Wermes, V. Wiegering, I. Wieland, B. Zieger and R. B. Zotz. (2014) Therapy of inherited diseases of platelet function. Interdisciplinary S2K guideline of the Permanent Paediatric Committee of the Society of Thrombosis and Haemostasis Research (GTH e. V.). Hamostaseologie 34:269.

Watzka, M., C. Geisen, M. Scheer, R. Wieland, V. Wiegering, T. Dorner, H. J. Laws, F. Gumruk, S. Hanalioglu, S. Unal, D. Albayrak and J. Oldenburg. (2014) Bleeding and non-bleeding phenotypes in patients with GGCX gene mutations. Thromb Res 134:856.

Wiegering, A., F. Endter, V. A. Wiegering, C. T. Germer and J. Maroske. (2014) Bowl obstruction due to an incomplete obliterated omphalomesenteric duct. Klin Padiatr 226:80.

Wiegering, V., J. Frank, S. Freudenberg, H. Morbach, P. G. Schlegel, M. Eyrich and B. Winkler. (2014) Impaired B-cell reconstitution in children after chemotherapy for standard or medium risk acute precursor B-lymphoblastic leukemia. Leuk Lymphoma 55:870.

Wiegering V, Schmid S, Andres O, Wirth C, Wiegering A, Meyer T, Winkler B, Schlegel PG, Eyrich M. (2014) Thrombosis as a complication of central venous access in pediatric patients with malignancies: a 5-year single-center experience. BMC Hematol 14(1):18.

Wölfl M, Greenberg PD. (2014) Antigen-specific activation and cytokine-facilitated expansion of naive, human CD8+ T cells. Nat Protoc 2014 Apr;9(4):950-66.

Ziegler S, Skibbe K, Walker A, Ke X, Heinemann FM, Heinold A, Mok JY, van Esch WJ, Yang D, Wölfl M, Timm J. (2014) Impact of sequence variation in a dominant HLA-A*02-restricted epitope in hepatitis C virus on priming and cross-reactivity of CD8+ T cells.
J Virol 2014 Oct;88(19):11080-90.

2013

Andres O, Strehl K, Kölsch U, Kunzmann S, Lebrun AH, Stroh T, Schwarz K, Morbach H, von Bernuth H, Liese J. (2013) Even in pneumococcal sepsis CD62L shedding on granulocytes proves to be a reliable functional test for the diagnosis of interleukin-1 receptor-associated kinase-4 deficiency. Pediatr Infect Dis J 32:1017-9.

Bäuerlein CA, Riedel SS, Baker J, Brede C, Garrote AL, Chopra M, Ritz M, Beilhack GF, Schulz S, Zeiser R, Schlegel PG, Einsele H, Negrin RS, Beilhack A. (2013) A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model. BMC Med 21;11:134.

Beier R, Albert MH, Bader P, Borkhardt A, Creutzig U, Eyrich M, Ehlert K, Gruhn B, Greil J, Handgretinger R, Holter W, Klingebiel T, Kremens B, Lang P, Mauz-Körholz C, Meisel R, Müller I, Peters C, Reinhardt D, Sedlacek P, Schulz A, Schuster FR, Schrauder A, Strahm B, Sykora KW, Wössmann W, Zimmermann M, Sauer MG. (2013) Allo-SCT using BU, CY and melphalan for children with AML in second CR. Bone Marrow Transplant 48:651-6.

Beier R, Schulz A, Hönig M, Eyrich M, Schlegel PG, Holter W, Stachel KD, Ehlert K, Greil J, Nürnberger W, Wössmann W, Bader P, Urban C, Müller I, Suttorp M, Sauer M, Gruhn B, Meisel R, Zimmermann M, Sykora KW. (2013) Long-term follow-up of children conditioned with Treosulfan: German and Austrian experience. Bone Marrow Transplant 48:491-501.

Brehm C, Huenecke S, Pfirrmann V, Rossig C, Mackall CL, Bollard CM, Gottschalk S, Schlegel PG, Klingebiel T, Bader P. (2013) Highlights of the third International Conference on Immunotherapy in Pediatric Oncology. Pediatr Hematol Oncol 30:349-66.

Chapuis AG, Ragnarsson GB, Nguyen HN, Chaney CN, Pufnock JS, Schmitt TM, Duerkopp N, Roberts IM, Pogosov GL, Ho WY, Ochsenreither S, Wölfl M, Bar M, Radich JP, Yee C, Greenberg PD. (2013) Transferred WT1-reactive CD8+ T cells can mediate antileukemic activity and persist in post-transplant patients. Sci Transl Med 5:174ra27.

Dantonello TM, Int-Veen C, Schuck A, Seitz G, Leuschner I, Nathrath M, Schlegel PG, Kontny U, Behnisch W, Veit-Friedrich I, Kube S, Hallmen E, Kazanowska B, Ladenstein R, Paulussen M, Ljungman G, Bielack SS, Klingebiel T, Koscielniak E; Cooperative Weichteilsarkom Studiengruppe. (2013) Survival following disease recurrence of primary localized alveolar rhabdomyosarcoma. Pediatr Blood Cancer 60:1267-73.

Eyrich M, Rachor J, Schreiber SC, Wölfl M, Schlegel PG. (2013) Dendritic cell vaccination in pediatric gliomas: lessons learnt and future perspectives. Front Pediatr 10;1:12.

Friedrich C, von Bueren AO, von Hoff K, Gerber NU, Ottensmeier H, Deinlein F, Benesch M, Kwiecien R, Pietsch T, Warmuth-Metz M, Faldum A, Kuehl J, Kortmann RD, Rutkowski S. (2013) Treatment of young children with CNS-primitive neuroectodermal tumors/pineoblastomas in the prospective multicenter trial HIT 2000 using different chemotherapy regimens and radiotherapy. Neuro Oncol 15:224-34.

Friedrich C, von Bueren AO, von Hoff K, Kwiecien R, Pietsch T, Warmuth-Metz M, Hau P, Deinlein F, Kuehl J, Kortmann RD, Rutkowski S. (2013) Treatment of adult nonmetastatic medulloblastoma patients according to the paediatric HIT 2000 protocol: a prospective observational multicentre study. Eur J Cancer 49:893-903.

Hofmann M, Schlegel PG, Hippert F, Schmidt P, von-Schweinitz D, Leuschner I, Göbel U, Calaminus G, Schneider DT; MAKEI study group. (2013) Testicular sex cord stromal tumors: analysis of patients from the MAKEI study. Pediatr Blood Cancer 60:1651-5.

Jones DT, Hutter B, Jäger N, Korshunov A, Kool M, Warnatz HJ, Zichner T, Lambert SR, Ryzhova M, Quang DA, Fontebasso AM, Stütz AM, Hutter S, Zuckermann M, Sturm D, Gronych J, Lasitschka B, Schmidt S, Seker-Cin H, Witt H, Sultan M, Ralser M, Northcott PA, Hovestadt V, Bender S, Pfaff E, Stark S, Faury D, Schwartzentruber J, Majewski J, Weber UD, Zapatka M, Raeder B, Schlesner M, Worth CL, Bartholomae CC, von Kalle C, Imbusch CD, Radomski S, Lawerenz C, van Sluis P, Koster J, Volckmann R, Versteeg R, Lehrach H, Monoranu C, Winkler B, Unterberg A, Herold-Mende C, Milde T, Kulozik AE, Ebinger M, Schuhmann MU, Cho YJ, Pomeroy SL, von Deimling A, Witt O, Taylor MD, Wolf S, Karajannis MA, Eberhart CG, Scheurlen W, Hasselblatt M, Ligon KL, Kieran MW, Korbel JO, Yaspo ML, Brors B, Felsberg J, Reifenberger G, Collins VP, Jabado N, Eils R, Lichter P, Pfister SM. (2013) International Cancer Genome Consortium PedBrain Tumor Project (2013): Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma. Nat Genet 45:927-32.

Shmukler BE, Mukodzi S, Andres O, Eber S, Alper SL. (2013) Autosomal dominant overhydrated stomatocytosis associated with the heterozygous RhAG mutation F65S: a case of missed heterozygosity due to allelic dropout. Br J Haematol 161:602-4.

Tan SM, Kapp M, Flechsig C, Kapp K, Rachor JE, Eyrich M, Loeffler J, Einsele H, Grigoleit GU. (2013) Stimulating surface molecules, Th1-polarizing cytokines, proven trafficking--a new protocol for the generation of clinical-grade dendritic cells. Cytotherapy 15:492-506.

Wiegering V, Andres O, Schlegel PG, Deinlein F, Eyrich M, Sturm A. (2013) Hyperfibrinolysis and acquired factor XIII deficiency in newly diagnosed pediatric malignancies. Haematologica 98:e90-1.

Wiegering V, Schlegel PG, Winkler B. (2013) Immune function in newly diagnosed children with malignancy. J Pediatr Hematol Oncol 34:559-64.

Wiegering V, Sauer K, Winkler B, Eyrich M, Schlegel PG. (2013) Indication for allogeneic stem cell transplantation in Glanzmann's thrombasthenia. Hamostaseologie 33:305-12.

Wiegering V, Winkler B, Haubitz I, Wölfl M, Schlegel PG, Eyrich M. (2013) Lower TGFß serum levels and higher frequency of IFNγ-producing T cells during early immune reconstitution in surviving children after allogeneic stem cell transplantation. Pediatr Blood Cancer 60:121-8.

Winkler B, Kuhn S, Kunzmann S, Ruf K, Wiegering V, Schlegel PG. (2013) Severe Hypertriglyceridemia in a 6 Year Old Boy with ALL Relapse: Successfully Treated with Plasmapheresis. Klin Padiatr 225:364-365.

Wölfl M, Langhammer F, Wiegering V, Eyrich M, Schlegel PG. (2013) Dasatinib medication causing profound immunosuppression in a patient after haploidentical SCT: functional assays from whole blood as diagnostic clues. Bone Marrow Transplant 48:875-7.

Wölfl M, Schwinn S, Yoo YE, Reß ML, Braun M, Chopra M, Schreiber SC, Ayala VI, Ohlen C, Eyrich M, Beilhack A, Schlegel PG. (2013) Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis. Blood 122:1203-13.

2012

Corbacioglu S, Cesaro S, Faraci M, Valteau-Couanet D, Gruhn B, Rovelli A, Boelens JJ, Hewitt A, Schrum J, Schulz AS, Müller I, Stein J, Wynn R, Greil J, Sykora KW, Matthes-Martin S, Führer M, O'Meara A, Toporski J, Sedlacek P, Schlegel PG, Ehlert K, Fasth A, Winiarski J, Arvidson J, Mauz-Körholz C, Ozsahin H, Schrauder A, Bader P, Massaro J, D'Agostino R, Hoyle M, Iacobelli M, Debatin KM, Peters C, Dini G. (2012) Defibrotide for prophylaxis of hepatic veno-occlusive disease in paediatric haematopoietic stem-cell transplantation : an open-label, phase 3, randomised controlled trial. Lancet 1301-1309.

Gerber NU, von Hoff K, von Bueren AO, Treulieb W, Deinlein F, Benesch M, Zwiener I, Soerensen N, Warmuth-Metz M, Pietsch T, Mittler U, Kuehl J, Kortmann RD, Grotzer MA, Rutkowski S. (2012) A long duration of the prediagnostic symptomatic interval is not associated with an unfavourable prognosis in childhood medulloblastoma. Eur J Cancer 48:2028-36.

Kapp M, Grigoleit GU, Dietz UA, Wiegering V, Stuhler G, Schlegel N, Einsele H, Mielke S, Germer CT, Strauss A. (2012) Prevention of major infectious complications by pre-emptive enterostomy in patients awaiting allogeneic stem cell transplantation. Int J Colorectal Dis 27:1683-1685.

Kronik N, Kogan Y, Schlegel PG, Wölfl M. (2012) Improving T cell immunotherapy for melanoma through a mathematically motivated strategy: efficacy in numbers? J of Immunotherapy 35:116-124.

Neubauer H, Evangelista L, Hassold N, Winkler B, Schlegel PG, Köstler H, Hahn D, Beer M. (2012) Diffusion-weighted MRI for detection and differentiation of musculoskeletal tumor-like lesions in pediatric patients. World J Pediatr 8(4):342-49.

Ronceray L, Pötschger U, Janka G, Gadner H, Minkov M; German Society for Pediatric Hematology and Oncology, Langerhans Cell Histiocytosis Study Group. (2012) Pulmonary involvement in pediatric-onset multisystem Langerhans cell histiocytosis: effect on course and outcome. J Pediatr 161(1):129-33.e1-3.

Sandrock K, Halimeh S, Wiegering V, Kappert G, Sauer K, Deeg N, Busse E. Zieger B. (2012) Homozygous point mutations in platelet glycoprotein ITGA2B gene as cause of Glanzmann thrombasthenia in 2 families. Klin Pädiatr 224:174-178.

Slee RB, Steiner CM, Herbert BS, Vance GH, Hickey RJ, Schwarz T, Christan S, Radovich M, Schneider BP, Schindelhauer D, Grimes BR. (2012) Cancer-associated alteration of pericentromeric heterochromatin may contribute to chromosome instability. Oncogene 31:3244-53.

Styczynski J, Balduzzi A, Gil L, Labopin M, Hamladji RM, Marktel S, Yesilipek MA, Fagioli F, Ehlert K, Matulova M, Dalle JH, Wachowiak J, Miano M, Messina C, Diaz MA, Vermylen C, Eyrich M, Badell I, Dreger P, Gozdzik J, Hutt D, Rascon J, Dini G, Peters C. (2012) Risk of complications during hematopoietic stem cell collection in pediatric sibling donors: a prospective EBMT-PDWP study. Blood 119:2935-42.

Thiel U, Wolf P, Wawer A, Blaeschke F, Grunewald TG, von Lüttichau IT, Klingebiel T, Bader P, Borkhardt A, Laws HJ, Handgretinger R, Lang P, Schlegel PG, Eyrich M, Gruhn B, Ehninger G, Koscielniak E, Klein C, Sykora KW, Holler E, Mauz-Körholz C, Woessmann W, Richter GH, Schmidt AH, Peters C, Dirksen U, Jürgens H, Bregni M, Burdach. (2012) S. Human leukocyte antigen distribution in German Caucasians with advanced Ewing’s sarcoma. Klin Pädiatr 224:353-358.

Wiegering V, Schlegel PG, Winkler B. (2012) Immune function in newly diagnosed children with malignancy. J Pediatr Hematol Oncol, 34:559-564.

Wolff B, Ng A, Roth D, Parthey K, Warmuth-Metz M, Eyrich M, Kordes U, Kortmann R, Pietsch T, Kramm C, Wolff JE. (2012) Pediatric high grade glioma of the spinal cord: results of the HIT-GBM database. J Neurooncol 107:139-46.

2011

Eyrich M, Schreiber SC, Wollny G, Ziegler H, Schlenker R, Koch-Buttner K, Wolfl M, Schlegel PG, Schilbach K. (2011) Pre-differentiated human committed T-lymphoid progenitors promote peripheral T-cell re-constitution after stem cell transplantation in immunodeficient mice. Eur J Immunol 41:3596-3603.

Gerber NU, von Hoff K, von Bueren AO, Treulieb W, Warmuth-Metz M, Pietsch T, Soerensen N, Faldum A, Emser A, Schlegel PG, Deinlein F, Kortmann RD, Rutkowski S. (2011) Outcome of 11 children with ependymoblastoma treated within the prospective HIT-trials between 1991 and 2006. J Neurooncol 102:459-469.

Kreyenberg H, Jarisch A, Bayer C, Schuster B, Willasch A, Strahm B, Kremens B, Gruhn B, Schrauder A, Burdach S, Fuhrer M, Rossig C, Kabisch H, Schlegel PG, Stachel D, Beck JF, Mauz-Koerholz C, Chung TL, Holler E, Klingebiel T, Bader P. (2011) NOD2/CARD15 gene polymorphisms affect outcome in pediatric allogeneic stem cell transplantation. Blood 118:1181-1184.

Lang P, Pfeiffer M, Teltschik HM, Schlegel P, Feuchtinger T, Ebinger M, Klingebiel T, Bader P, Schlegel PG, Beck J, Greil J, Handgretinger R. (2011) Natural killer cell activity influences outcome after T cell depleted stem cell transplantation from matched unrelated and haploidentical donors. Best Pract Res Clin Haematol 24:403-411.

Pufnock JS, Cigal M, Rolczynski LS, Andersen-Nissen E, Wolfl M, McElrath MJ, Greenberg PD. (2011) Priming CD8+ T cells with dendritic cells matured using TLR4 and TLR7/8 ligands together enhances generation of CD8+ T cells retaining CD28. Blood 117: 6542-6551.

Rettinger E, Willasch AM, Kreyenberg H, Borkhardt A, Holter W, Kremens B, Strahm B, Woessmann W, Mauz-Koerholz C, Gruhn B, Burdach S, Albert MH, Schlegel PG, Klingebiel T, Bader P. (2011) Preemptive immunotherapy in childhood acute myeloid leukemia for patients showing evidence of mixed chimerism after allogeneic stem cell transplantation. Blood 118:5681-5688.

Schlegel P, Teltschik HM, Pfeiffer M, Handgretinger R, Schumm M, Koscielniak E, Feuchtinger T, Klingebiel T, Bader P, Schlegel PG, Greil J, Lang P. (2011) Long-term IL-2 therapy after transplantation of T cell depleted stem cells from alternative donors in children. Best Pract Res Clin Haematol 24:443-452.

Thiel U, Wawer A, Wolf P, Badoglio M, Santucci A, Klingebiel T, Basu O, Borkhardt A, Laws HJ, Kodera Y, Yoshimi A, Peters C, Ladenstein R, Pession A, Prete A, Urban EC, Schwinger W, Bordigoni P, Salmon A, Diaz MA, Afanasyev B, Lisukov I, Morozova E, Toren A, Bielorai B, Korsakas J, Fagioli F, Caselli D, Ehninger G, Gruhn B, Dirksen U, Abdel-Rahman F, Aglietta M, Mastrodicasa E, Torrent M, Corradini P, Demeocq F, Dini G, Dreger P, Eyrich M, Gozdzik J, Guilhot F, Holler E, Koscielniak E, Messina C, Nachbaur D, Sabbatini R, Oldani E, Ottinger H, Ozsahin H, Schots R, Siena S, Stein J, Sufliarska S, Unal A, Ussowicz M, Schneider P, Woessmann W, Jurgens H, Bregni M, Burdach S. (2011) No improvement of survival with reduced- versus high-intensity conditioning for allogeneic stem cell transplants in Ewing tumor patients. Ann Oncol 22:1614-1621.

von Bueren AO, von Hoff K, Pietsch T, Gerber NU, Warmuth-Metz M, Deinlein F, Zwiener I, Faldum A, Fleischhack G, Benesch M, Krauss J, Kuehl J, Kortmann RD, Rutkowski S. (2011) Treatment of young children with localized medulloblastoma by chemotherapy alone: results of the prospective, multicenter trial HIT 2000 confirming the prognostic impact of histology. Neuro Oncol 13:669-679.

von Bueren AO, Warmuth-Metz M, Schlegel PG, Soerensen N, Krauss J, Roggendorf W, Pietsch T, Feiden W, Graf N, Pohl F, Flentje M, Kuehl J, Rutkowski S. (2011) Late complete remission of supratentorial primitive neuroectodermal tumor (CNS-PNET) after multiple relapses. Pediatr Blood Cancer 56:503-505.

von Hoff K, Hinkes B, Dannenmann-Stern E, von Bueren AO, Warmuth-Metz M, Soerensen N, Emser A, Zwiener I, Schlegel PG, Kuehl J, Fruhwald MC, Kortmann RD, Pietsch T, Rutkowski S. (2011) Frequency, risk-factors and survival of children with atypical teratoid rhabdoid tumors (AT/RT) of the CNS diagnosed between 1988 and 2004, and registered to the German HIT database. Pediatr Blood Cancer 57:978-985.

Wiegering V, Eyrich M, Rutkowski S, Wolfl M, Schlegel PG, Winkler B. (2011) TH1 predominance is associated with improved survival in pediatric medulloblastoma patients.
Cancer Immunol Immunother 60:693-703.

Wiegering V, Schick J, Beer M, Weissbrich B, Gattenlohner S, Girschick HJ, Liese J, Schlegel PG, Eyrich M. (2011) Varicella-zoster virus infections in immunocompromised patients - a single centre 6-years analysis. BMC Pediatr 11:31.

Wiegering V, Winkler B, Langhammer F, Wolfl M, Wirbelauer J, Sauer K, Kobsar A, Meyer T, Strauss A, Bakchoul T, Eyrich M, Schlegel PG. (2011) Allogeneic hematopoietic stem cell transplantation in Glanzmann thrombasthenia complicated by platelet alloimmunization. Klin Padiatr 223:173-175.

Wölfl M, Merker K, Morbach H, Van Gool SW, Eyrich M, Greenberg PD, Schlegel PG. (2011) Primed tumor-reactive multifunctional CD62L+ human CD8+ T cells for immunotherapy. Cancer Immunol Immunother 60:173-18.

2010

Benesch M, Weber-Mzell D, Gerber NU, von Hoff K, Deinlein F, Krauss J, Warmuth-Metz M, Kortmann RD, Pietsch T, Driever PH, Quehenberger F, Urban C, Rutkowski S. (2010) Ependymoma of the spinal cord in children and adolescents: a retrospective series from the HIT database. J Neurosurg Pediatr 6:137-144.

Coosemans A, Wolfl M, Berneman ZN, Van Tendeloo V, Vergote I, Amant F, Van Gool SW. (2010) Immunological response after therapeutic vaccination with WT1 mRNA-loaded dendritic cells in end-stage endometrial carcinoma. Anticancer Res 30:3709-3714.

Niemeyer CM, Kang MW, Shin DH, Furlan I, Erlacher M, Bunin NJ, Bunda S, Finklestein JZ, Sakamoto KM, Gorr TA, Mehta P, Schmid I, Kropshofer G, Corbacioglu S, Lang PJ, Klein C, Schlegel PG, Heinzmann A, Schneider M, Stary J, van den Heuvel-Eibrink MM, Hasle H, Locatelli F, Sakai D, Archambeault S, Chen L, Russell RC, Sybingco SS, Ohh M, Braun BS, Flotho C, Loh ML. (2010) Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia. Nat Genet 42:794-800.

Rutkowski S, von Hoff K, Emser A, Zwiener I, Pietsch T, Figarella-Branger D, Giangaspero F, Ellison DW, Garre ML, Biassoni V, Grundy RG, Finlay JL, Dhall G, Raquin MA, Grill J. (2010) Survival and prognostic factors of early childhood medulloblastoma: an international meta-analysis. J Clin Oncol 28:4961-4968.

Schlegel PG, Eyrich M, Kramm C, van Gool S. (2010) Tumor vaccination for high-grade glioma. Pediatr Blood Cancer 55:1437.

von Hoff K, Hartmann W, von Bueren AO, Gerber NU, Grotzer MA, Pietsch T, Rutkowski S. (2010) Large cell/anaplastic medulloblastoma: outcome according to myc status, histopathological, and clinical risk factors. Pediatr Blood Cancer 54:369-376.

Wolff JE, Driever PH, Erdlenbruch B, Kortmann RD, Rutkowski S, Pietsch T, Parker C, Metz MW, Gnekow A, Kramm CM. (2010) Intensive chemotherapy improves survival in pediatric high-grade glioma after gross total resection: results of the HIT-GBM-C protocol. Cancer 116:705-12.

Wolfl M, Merker K, Morbach H, Van Gool SW, Eyrich M, Greenberg PD, Schlegel PG. (2010) Primed tumor-reactive multifunctional CD62L+ human CD8+ T cells for immunotherapy. Cancer Immunol Immunother 60:173-186.

Kontakt, Öffnungszeiten, Sprechzeiten

Öffnungszeiten:

nach telefonischer Terminvereinbarung
+49 931 201-27855

 

 

Telefon:

Kinderklinik-Pforte
+49 931 201-27728 oder
+49 931 201-27915

Notfälle
+49 931 201-27728

Intensivstation
+49 931 201-27726

Direktions-Sekretariat
+49 931 201-27831 oder
+49 931 201-27832

Fax:
+49 931 201-27798


Anschrift:

Kinderklinik und Poliklinik des Universitätsklinikums und der Bayerischen Julius-Maximilians-Universität | Josef-Schneider-Straße 2 | Haus D31 | 97080 Würzburg | Deutschland